TFAP2A promotes NSCLC malignant progression by enhancing AOC1 transcription [PDF]
HereditasBackground Non-small cell lung cancer (NSCLC) has high mortality, and patients show variable outcomes and drug responses. Amine oxidase copper-containing 1 (AOC1) is considered an oncogene in many types of tumors. Transcription factor AP-2 alpha (TFAP2A)
Xiang Miao +5 more
exaly +5 more sources
METTL14 contributes to the progression of nasopharyngeal carcinoma through regulating the stability of AOC1 mRNA [PDF]
HereditasBackground Nasopharyngeal carcinoma (NPC) is a malignant epithelial tumor of the nasopharyngeal mucosa with a high incidence rate all over the world. Methyltransferase-like 14 (METTL14) is a major RNA N6-adenosine methyltransferase implicated in tumor ...
Changan Hu +4 more
exaly +6 more sources
Cumulative effect of AOC1 gene variants on symptoms and pathological conditions in adult women with fibromyalgia: a pilot study [PDF]
Frontiers in Genetics, 2023 Introduction: The amine oxidase copper-containing 1 (AOC1) gene encodes for the diamine oxidase (DAO) enzyme. DAO is an enzyme that catabolizes some molecules, including histamine, and is the degradative enzyme in the polyamine catabolic pathway that is ...
Teresa Perucho +2 more
exaly +6 more sources
Increased AOC1 Expression Promotes Cancer Progression in Colorectal Cancer [PDF]
Frontiers in Oncology, 2021 BackgroundAmine oxidase copper containing 1 (AOC1) is a gene whose biological function in colorectal cancer (CRC) has not been elucidated. Therefore, the purpose of this study was to investigate the clinical significance of AOC1 expression in CRC and its
Zhehui Zhu, Wenjun Ding, Weimin Xu
exaly +5 more sources
Cell Death and Disease, 2022 Amine oxidase copper-containing 1 (AOC1) is considered an oncogene in many types of tumors. Nevertheless, there have been no investigations of AOC1 and its regulatory mechanism in prostate cancer.
exaly +4 more sources
Integrated single-cell and transcriptome sequencing data reveal the value of AOC1 in gliomas tumor microenvironment and prognosis [PDF]
BMC CancerBackground Glioma is a primary brain tumor that is frequently encountered in humans, with malignant gliomas representing an exceptionally aggressive subtype.
Jun Liu +6 more
exaly +3 more sources
Identification and Validation of Tryptophan Metabolism–Related Genes in Diabetic Kidney Disease and Construction of a Clinical Prediction Model [PDF]
Journal of Diabetes ResearchConclusion: Our study suggests that the AOC1, HAAO, and STAT1 genes may be potential diagnostic biomarkers of tubular injury in DKD. OGDHL and TDO2 may be potential diagnostic biomarkers of glomerular injury in DKD. The model constructed using AOC1, HAAO,
Shaojie Liu +6 more
doaj +3 more sources
Photodynamic Therapy of Novel Photosensitizer Ameliorates TNBS-Induced Ulcerative Colitis via Inhibition of AOC1 [PDF]
Frontiers in Pharmacology, 2021 Ulcerative colitis (UC), a chronic, nonspecific inflammatory bowel disease characterized by continuous and diffuse inflammatory changes in the colonic mucosa, requires novel treatment method.
Tianjun Liu
exaly +5 more sources
Excessive DAO inhibits myoblast migration, leading to impaired myotube fusion and muscle strength decline by reducing ECM [PDF]
Frontiers in Bioengineering and BiotechnologyIntroductionThe molecular mechanisms underlying muscle strength decline, particularly in age-related conditions such as sarcopenia, remain poorly understood.
Xiang Liu +10 more
doaj +2 more sources
Research on the potential mechanisms and therapeutic drug for the co-occurrence of major depressive disorder in castration-resistant prostate cancer [PDF]
Scientific ReportsDepression in patients with prostate cancer (PC) has become a significant public health issue. Given the high treatment failure rate and short life expectancy of patients with castration-resistant prostate cancer (CRPC), their risk of developing major ...
Lei Xu +6 more
doaj +2 more sources