m6A-enriched lncRNA LINC00839 promotes tumor progression by enhancing TAF15-mediated transcription of amine oxidase AOC1 in nasopharyngeal carcinoma [PDF]
Journal of Biological Chemistry, 2023 Dysregulation of long noncoding RNAs (lncRNAs) contributes to tumorigenesis by modulating specific cancer-related pathways, but the roles of N6-methyladenosine (m6A)-enriched lncRNAs and underlying mechanisms remain elusive in nasopharyngeal carcinoma (NPC). Here, we reanalyzed the previous genome-wide analysis of lncRNA profiles in 18 pairs of NPC and
Weihong Zheng, zhixuan li, Guan-Qun Zhou
exaly +4 more sources
Shipin gongye ke-ji, 2022 Objective: To explore the molecular mechanism driving the tea polyphenol epigallocatechin-3-gallate (EGCG)-exerted protective effect on hydrogen peroxide (H2O2)-induced cell apoptosis of human cardiomyocyte HCM cell lines.
Yingxin BI +8 more
doaj +2 more sources
Effect of diamine oxidase (DAO) enzyme dietary supplementation in subjects with insomnia symptoms and single nucleotide polymorphisms of the AOC1 gene: a randomized double-blind placebo-controlled study [PDF]
Sleep Medicine: XObjective: This exploratory study was designed to assess the effect of a diamine oxidase (DAO) enzyme supplement on insomnia symptoms in patients with alterations of the AOC1 gene, which encodes the DAO enzyme.
Júlia Ferrer-Garcia +6 more
doaj +2 more sources
The tree of life of copper-containing amine oxidases [PDF]
Frontiers in Plant ScienceCopper-containing amine oxidases (CuAOs) catalyze the terminal oxidation of polyamines (PAs), producing ammonium, an aminoaldehyde, and hydrogen peroxide (H2O2). Plant CuAOs are induced by stress-related hormones such as methyl-jasmonate (MeJA), abscisic
Zaibao Zhang +5 more
doaj +2 more sources
AOC1 Contributes to Tumor Progression by Promoting the AKT and EMT Pathways in Gastric Cancer
Cancer Management and Research, 2020 Fen Xu,1,2 Yun Xu,3 Jian-Hui Xiong,4 Jing-Hui Zhang,2 Jian Wu,2 Jie Luo,2 Jian-Ping Xiong1 1The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, People’s Republic of China; 2Jiangxi Medical College, Shangrao, Jiangxi, People ...
Xu F +6 more
doaj +4 more sources
Prevalence of Genetic Diamine Oxidase (DAO) Deficiency in Female Patients with Fibromyalgia in Spain
Biomedicines, 2023 Diamine oxidase (DAO) is an enzyme that metabolizes intestinal histamine. Single nucleotide polymorphisms (SNPs) of the Amine Oxidase Copper Containing 1 (AOC1) gene can lead to low enzymatic activity or functionality in histamine metabolism.
EVA RUIZ CASARES +2 more
exaly +3 more sources
Integrated Urinary and Tissue Proteomic Signatures Reveal Core and Progression Biomarkers in MRI-Visible and MRI-Non-Visible Prostate Cancer [PDF]
LifeBackground: Prostate cancer (PCa) shows a marked biological heterogeneity that is closely associated with tumor aggressiveness. A substantial proportion of clinically significant tumors remain undetected by multiparametric magnetic resonance imaging ...
Ana Blanca +9 more
doaj +2 more sources
Extrachromosomal DNA drives molecular and clinical heterogeneity in hepatocellular carcinoma: a multi-omics analysis and prognostic model development [PDF]
Human GenomicsBackground Extrachromosomal DNA (ecDNA) is an emerging hallmark of cancer that promotes tumor evolution and heterogeneity. However, the molecular characteristics and clinical significance of ecDNA in hepatocellular carcinoma (HCC) remain incompletely ...
Kai Huang +9 more
doaj +2 more sources
Transcriptomics and metabolomics insights into the seasonal dynamics of meat quality in yak on the Qinghai-Tibetan Plateau [PDF]
BMC GenomicsBackground Meat quality in yak is influenced by the fluctuation of nutritional composition in different grazing seasons on the Qinghai-Tibetan Plateau. However, the molecular mechanism underlying in yak meat remains unknown.
Tongqing Guo +9 more
doaj +2 more sources
Low expression and significance of AOC1 in prostate adenocarcinoma. [PDF]
Transl Androl UrolWang HQ +12 more
europepmc +2 more sources