Results 141 to 150 of about 7,237 (173)

Apelin and its receptor are expressed in human osteoblasts

Regulatory Peptides, 2006
Apelin is a recently discovered peptide that is the endogenous ligand for the orphan G-protein-coupled receptor APJ. Adipocytes can express and secrete apelin. The aim of this study was to characterize apelin and APJ expression in human osteoblasts and to investigate the effects of apelin on osteoblasts.Apelin and APJ were expressed in human ...
Hui, Xie, Si-yuan, Tang, Rong-rong, Cui, Jiao, Huang, Xiao-hong, Ren, Ling-qing, Yuan, Ying, Lu, Min, Yang, Hou-de, Zhou, Xian-ping, Wu, Xiang-hang, Luo, Er-yuan, Liao   +11 more
openaire   +2 more sources

Apelin Receptor Signaling During Mesoderm Development

2020
The Apelin receptor (Aplnr) is a G-protein coupled receptor which has a wide body distribution and various physiological roles including homeostasis, angiogenesis, cardiovascular and neuroendocrine function. Apelin and Elabela are two peptide components of the Aplnr signaling and are cleaved to give different isoforms which are active in different ...
Derya, Sağraç, Hatice Burcu, Şişli, Ayşegül, Doğan   +2 more
openaire   +2 more sources

Hormonal dependent expression of apelin and apelin receptor in the ovary and uterus of mice

Reproductive Biology
Apelin and APJ have been shown to regulate female reproductive functions. However, its uterine expression during the oestrous cycle and its regulation by ovarian steroids, along with gonadotropin regulation in the ovary, has not been investigated. This study aimed to analyze the steroid-dependent uterine expression of apelin/APJ in the uterus along ...
Borgohain, Anima, Guruswami, Gurusubramanian, Vikas Kumar, Roy   +2 more
openaire   +2 more sources

Apelin and its receptor APJ in cardiovascular diseases

Clinica Chimica Acta, 2014
Apelin is an adipokine that has been identified as an endogenous ligand for the orphan receptor APJ. Apelin and APJ are expressed in a diverse range of tissues with particular preponderance for the heart and vasculature. Apelin has powerful positive inotropic actions and causes endothelium- and nitric oxide-dependent vasodilatation.
Xiao-Hua, Yu, Zhi-Bin, Tang, Li-Jing, Liu, Hong, Qian, Shi-Lin, Tang, Da-Wei, Zhang, Guo-Ping, Tian, Chao-Ke, Tang   +7 more
openaire   +2 more sources

Effects of apelin levels, apelin gene polymorphism and apelin receptor

2017
Abstract Not ...
Keleş, Dilek, Özhan, Bayram, Altıntaş, Fatih, Akdağ, Beyza   +3 more
openaire   +1 more source

Apelin receptors: From signaling to antidiabetic strategy

European Journal of Pharmacology, 2015
The G protein-coupled receptor APJ and its cognate ligand, apelin, are widely expressed throughout human body. They are implicated in different key physiological processes such as angiogenesis, cardiovascular functions, fluid homeostasis and energy metabolism regulation. On the other hand, this couple ligand-receptor is also involved in the development
C, Chaves-Almagro, I, Castan-Laurell, C, Dray, C, Knauf, P, Valet, B, Masri   +5 more
openaire   +2 more sources

Discovery of a Competitive Apelin Receptor (APJ) Antagonist

ChemMedChem, 2011
AbstractThe apelin receptor (APJ) is a class A G‐protein‐coupled receptor (GPCR) and is a putative target for the treatment of cardiovascular and metabolic diseases. Apelin‐13 (NH2‐QRPRLSHKGPMPF‐COOH) is a vasoactive peptide and one of the most potent endogenous inotropic agents identified to date.
N J Maximilian, Macaluso, Sarah L, Pitkin, Janet J, Maguire, Anthony P, Davenport, Robert C, Glen   +4 more
openaire   +2 more sources

Apelins and the Apelin Receptor

2008
Anthony P. Davenport, Sarah L. Pitkin, Janet J. Maguire   +2 more
openaire   +1 more source

Apelin receptor

AfCS-Nature Molecule Pages, 2006
openaire   +1 more source

Apelin and Receptor☆

2017
X. Iturrioz, C. Llorens-Cortes
openaire   +1 more source