Results 121 to 130 of about 7,237 (173)

Expression of the apelin receptor, a novel potential therapeutic target, and its endogenous ligands in diverse stem cell populations in human glioblastoma. [PDF]

Front Neurosci
Williams TL, Nwokoye P, Kuc RE, Smith K, Paterson AL, Allinson K, Maguire JJ, Davenport AP.   +7 more
europepmc   +1 more source

The biased apelin receptor agonist, MM07, reverses Sugen/hypoxia-induced pulmonary arterial hypertension as effectively as the endothelin antagonist macitentan. [PDF]

Front Pharmacol
Williams TL, Nyimanu D, Kuc RE, Foster R, Glen RC, Maguire JJ, Davenport AP.   +6 more
europepmc   +1 more source

Individual phosphorylation sites at the C-terminus of the apelin receptor play different roles in signal transduction. [PDF]

Redox Biol, 2020
Chen J, Chen X, Li S, Jiang Y, Mao H, Zhang R, Ji B, Yan M, Cai X, Wang C.   +9 more
europepmc   +1 more source

Association of Apelin and Apelin Receptor Polymorphisms With the Risk of Comorbid Depression and Anxiety in Coronary Heart Disease Patients. [PDF]

Front Genet, 2020
Wang Y, Liu W, Xiao Y, Yuan H, Wang F, Jiang P, Luo Z.   +6 more
europepmc   +1 more source

Structure-guided discovery of a single-domain antibody agonist against human apelin receptor. [PDF]

Sci Adv, 2020
Ma Y, Ding Y, Song X, Ma X, Li X, Zhang N, Song Y, Sun Y, Shen Y, Zhong W, Hu LA, Ma Y, Zhang MY.   +12 more
europepmc   +1 more source

An orally active apelin receptor agonist improves Alzheimer’s disease pathology and cognitive functions by restoring microglial metabolism

Ma OK, Gillespie L, Wang P, Wong C, Zhou G, Bagnall J, Leung KMY, Iyaswamy A, Ho PW, Li M, Chan KH, Ng RC.   +11 more
europepmc   +1 more source

Immunohistochemical evaluation of apelin and VEGF expression in cortisol-producing adrenal adenomas. [PDF]

BMC Endocr Disord
Çalişkan Burgucu H, Günler T, Ömeroğlu E, Ünlü Y, Aksu O.   +4 more
europepmc   +1 more source

Structural Basis for Apelin Control of the Human Apelin Receptor [PDF]

Structure, 2017
Apelin receptor (APJR) is a key regulator of human cardiovascular function and is activated by two different endogenous peptide ligands, apelin and Elabela, each with different isoforms diversified by length and amino acid sequence. Here we report the 2.6-Å resolution crystal structure of human APJR in complex with a designed 17-amino-acid apelin ...
Suwen Zhao, Qingtong Zhou, Liaoyuan A Hu
exaly   +3 more sources