Results 131 to 140 of about 7,237 (173)

Apelin pathway in cardiovascular, kidney, and metabolic diseases: Therapeutic role of apelin analogs and apelin receptor agonists

Peptides, 2022
The apelin/apelin receptor (ApelinR) signal transduction pathway exerts essential biological roles, particularly in the cardiovascular system. Disturbances in the apelin/ApelinR axis are linked to vascular, heart, kidney, and metabolic disorders. Therefore, the apelinergic system has surfaced as a critical therapeutic strategy for cardiovascular ...
Amanda Almeida de Oliveira, John Christopher Vederas   +1 more
exaly   +3 more sources

Inhibition of the apelin/apelin receptor axis decreases cholangiocarcinoma growth [PDF]

Cancer Letters, 2017
Cholangiocarcinoma (CCA) is a malignancy of the biliary epithelium that is associated with low five-year survival. The apelin receptor (APLNR), which is activated by the apelin peptide, has not been studied in CCA. The purpose of this study is to determine if inhibition of the apelin/APLNR axis can inhibit CCA growth.Immunohistochemistry, rtPCR ...
Shannon Glaser, Francesca Bernuzzi, Tianhao Zhou   +2 more
exaly   +4 more sources

Apelin/Apelin receptor: A new therapeutic target in Polycystic Ovary Syndrome

Life Sciences, 2020
Polycystic ovary syndrome (PCOS) is an endocrinopathy, and it accounts for 75% of non-ovulatory infertile in women of childbearing age. It is clear that obesity, insulin resistance, dyslipidaemia coexist in PCOS. Apelin, as an endogenous ligand of the previously orphan receptor, is an adipokine that secreted by adipose tissue.
Zhongcheng Mo, Qi Liu
exaly   +3 more sources

Elabela/Toddler and apelin bind differently to the apelin receptor

FASEB Journal, 2020
Abstract Like apelin (pE13F, K17F), Elabela/Toddler is an endogenous ligand of the apelin receptor playing a key role in cardiovascular development. Elabela/Toddler exists as peptide fragments of 32 (Q32P), 22 (K22P) and 11 (C11P) amino acids.
Xavier Iturrioz, Pierre Couvineau, Catherine Llorens-Cortès   +2 more
exaly   +3 more sources

Presence and expression of apelin and apelin receptor in bitch placenta

Theriogenology, 2020
Apelin is a potent inotropic agent causing endothelium-mediated vasodilation and is involved in vessel formation by interacting with a specific receptor. Its cardiovascular profile suggests a role in the regulation of gestational hemodynamic changes. The expression of apelin and its receptor has been reported in some portions of the reproductive tract ...
Troisi A., Dall'Aglio C., Maranesi M., Orlandi R., Speranza R., Zerani M., Polisca A.   +6 more
openaire   +3 more sources

Characterization of Apelin, the Ligand for the APJ Receptor

Journal of Neurochemistry, 2000
Abstract: The apelin peptide was recently discovered and demonstrated to be the endogenous ligand for the G protein‐coupled receptor, APJ. A search of the GenBank databases retrieved a rat expressed sequence tag partially encoding the preproapelin sequence.
D K, Lee, R, Cheng, T, Nguyen, T, Fan, A P, Kariyawasam, Y, Liu, D H, Osmond, S R, George, B F, O'Dowd   +8 more
openaire   +2 more sources

Agonist-induced internalization and desensitization of the apelin receptor

Molecular and Cellular Endocrinology, 2016
Apelin acts via the G protein-coupled apelin receptor (APJ) to mediate effects on cardiovascular and fluid homeostasis. G protein-coupled receptor (GPCR) trafficking has an important role in the regulation of receptor signalling pathways and cellular functions, however in the case of APJ the mechanisms and proteins involved in apelin-induced ...
Anne-Marie O'Carroll, Stephen Lolait, Sharada Tilve   +2 more
exaly   +5 more sources

New structural insights into the apelin receptor: identification of key residues for apelin binding

The FASEB Journal, 2014
Apelin is the endogenous ligand of the orphan 7‐transmembrane domain GPCRAPJ, now named the apelin receptor (ApelinR). Apelin plays a prominent role in body fluid and cardiovascular homeostasis. To better understand the structural organization of the ApelinR, we built 3 homology 3‐dimensional (3D) models of the human ApelinR using ...
Gerbier, Romain, Leroux, Vincent, Couvineau, Pierre, Alvear-Perez, Rodrigo, Maigret, Bernard, Llorens-Cortes, Catherine, Iturrioz, Xavier   +6 more
openaire   +4 more sources

Hyperandrogenemia elevates expression of apelin and apelin receptor protein in the mice pituitary

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology
AbstractHyperandrogenemia is associated with polycystic ovarian syndrome (PCOS) and imbalances in the pituitary hormones, luteinizing hormone (LH) and follicle‐stimulating hormone (FSH) levels. Apelin and its receptor, APJ (class A, rhodopsin‐like G‐ protein‐coupled receptor), belongs to adipokines, and its expression has been shown in the pituitary ...
Preethi Riba, Borgohain Anima, Ayushmita Dutta, Guruswami Gurusubramanian, Vikas Kumar Roy   +4 more
openaire   +2 more sources

Apelin and G212A apelin receptor gene polymorphism in obese and diabese youth

Pediatric Obesity, 2014
SummaryObjectiveThe apelinergic system has been previously described to participate in fluid homeostasis, cardiac contractility, blood pressure and neo‐vascularization. The role of apelin in obesity and glucose metabolism has also lately gained interest; however, it still remains obscure.
E P, Kotanidou, K, Kalinderi, I, Kyrgios, S, Efraimidou, L, Fidani, E, Papadopoulou-Alataki, M, Eboriadou-Petikopoulou, A, Galli-Tsinopoulou   +7 more
openaire   +2 more sources