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Molecular Biological Comparison of Dental Pulp- and Apical Papilla-Derived Stem Cells [PDF]
International Journal of Molecular Sciences, 2022 Both the dental pulp and the apical papilla represent a promising source of mesenchymal stem cells for regenerative endodontic protocols. The aim of this study was to outline molecular biological conformities and differences between dental pulp stem ...
Matthias Widbiller +2 more
exaly +6 more sources
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Differentiation Potential of Dental Papilla, Dental Pulp, and Apical Papilla Progenitor Cells
Journal of Endodontics, 2010Regenerative endodontic procedures use the differentiation potential of embryonic and adult pulp progenitor cell populations to reconstitute dental structures.An in-depth search of the literature was accomplished to review biologic knowledge from basic research on tooth morphogenesis and differentiation, root development, dentin-pulp regeneration, pulp
Konstantinos Kodonas, Dimitrios Tziafas
exaly +3 more sources
Journal of Endodontics, 2017
Apical papilla represents a source of an enriched mesenchymal stem cell (MSC) population (stem cells of the apical papilla [SCAPs]) that modulates root development and may participate in regenerative endodontic procedures in immature teeth with pulp necrosis.
Anibal Diogenes +2 more
exaly +3 more sources
Apical papilla represents a source of an enriched mesenchymal stem cell (MSC) population (stem cells of the apical papilla [SCAPs]) that modulates root development and may participate in regenerative endodontic procedures in immature teeth with pulp necrosis.
Anibal Diogenes +2 more
exaly +3 more sources
Hypoxia Modulates the Differentiation Potential of Stem Cells of the Apical Papilla
Journal of Endodontics, 2014Stem cells from the apical papilla (SCAP) are a population of mesenchymal stem cells likely involved in regenerative endodontic procedures and have potential use as therapeutic agents in other tissues. In these situations, SCAP are exposed to hypoxic conditions either within a root canal devoid of an adequate blood supply or in a scaffold material ...
Anibal Diogenes +2 more
exaly +4 more sources
Hormesis and dental apical papilla stem cells
Chemico-Biological Interactions, 2022This paper provides an assessment of hormetic dose responses by stem cells of the apical papilla (SCAPs) from humans. Hormetic dose responses were induced in vitro by a broad range of agents, including dietary supplements (e.g., berberine, EGCG, resveratrol), pharmaceutical/commercial substances (e.g.
openaire +2 more sources
Direct Effect of Intracanal Medicaments on Survival of Stem Cells of the Apical Papilla
Journal of Endodontics, 2012Regenerative endodontic procedures are an alternative treatment for immature teeth with necrotic pulps. Typically, intracanal medicaments such as triple antibiotic paste (TAP) or double antibiotic paste (DAP) and calcium hydroxide (Ca[OH](2)) are used for disinfection.
Anibal Diogenes, Caio Ferraz
exaly +3 more sources
Angiotensin II Regulates Proliferation and Function of Stem Cells of Apical Papilla
Journal of Endodontics, 2020Stem cells of apical papilla (SCAP) may be affected by inflammatory mediators released by activation with lipopolysaccharide (LPS) from infected pulpal cavities of necrotic immature teeth. Therefore, this study aimed to investigate the presence of a local renin-angiotensin system (RAS) and the role of angiotensin II (Ang II) on the modulation of SCAP ...
Lais Nicolay, Pizzatto +5 more
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The Hidden Treasure in Apical Papilla: The Potential Role in Pulp/Dentin Regeneration and BioRoot Engineering [PDF]
Journal of Endodontics, 2008 Some clinical case reports have shown that immature permanent teeth with periradicular periodontitis or abscess can undergo apexogenesis after conservative endodontic treatment.
George T-J Huang +2 more
exaly +2 more sources
Profiling the Secretome of Human Stem Cells from Dental Apical Papilla
Stem Cells and Development, 2016Recent studies have shown that secretion of bioactive factors from mesenchymal stem cells (MSCs) plays a primary role in MSC-mediated therapy; especially for bone marrow-derived MSCs (BMSCs). MSCs from dental apical papilla (SCAPs) are involved in root development and may play a critical role in the formation of dentin and pulp.
Shi, Yu +3 more
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Effect of Bacterial Biofilm on the Osteogenic Differentiation of Stem Cells of Apical Papilla
Journal of Endodontics, 2017Although clinical success in regenerative endodontics is substantially high, histological success is limited to finding bone/cementum-like tissue instead of dentin within the canal space. The aims of this study were to investigate (1) the effect of bacterial biofilm on osteogenic gene expression in stem cells of the apical papilla (SCAP) and (2) the ...
Lakshmi, Vishwanat +8 more
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