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Overexpression of ephrinB2 in stem cells from apical papilla accelerates angiogenesis [PDF]

Oral Diseases, 2019
AbstractObjectivesWe aimed to accelerate angiogenesis in pulp regeneration by modulating ephrinB2 expression in stem cells from apical papilla (SCAPs).Materials and MethodsStem cells from apical papilla were transducted with ephrinB2‐lentiviral expression vector (ephrinB2‐SCAPs) in experimental group and green fluorescent protein (GFP‐SCAPs) in control
Changyong Yuan, Penglai Wang, Shaoyue Zhu, Zongxiang Liu, Wen Wang, Tengyu Geng, Waruna Lakmal Dissanayaka, Lijian Jin, Chengfei Zhang   +8 more
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Hormesis and dental apical papilla stem cells

Chemico-Biological Interactions, 2022
This paper provides an assessment of hormetic dose responses by stem cells of the apical papilla (SCAPs) from humans. Hormetic dose responses were induced in vitro by a broad range of agents, including dietary supplements (e.g., berberine, EGCG, resveratrol), pharmaceutical/commercial substances (e.g.
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The Hidden Treasure in Apical Papilla: The Potential Role in Pulp/Dentin Regeneration and BioRoot Engineering [PDF]

Journal of Endodontics, 2008
Some clinical case reports have shown that immature permanent teeth with periradicular periodontitis or abscess can undergo apexogenesis after conservative endodontic treatment.
George Huang, Songtao Shi, Wataru Sonoyama   +2 more
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Angiotensin II Regulates Proliferation and Function of Stem Cells of Apical Papilla

Journal of Endodontics, 2020
Stem cells of apical papilla (SCAP) may be affected by inflammatory mediators released by activation with lipopolysaccharide (LPS) from infected pulpal cavities of necrotic immature teeth. Therefore, this study aimed to investigate the presence of a local renin-angiotensin system (RAS) and the role of angiotensin II (Ang II) on the modulation of SCAP ...
Lais Nicolay, Pizzatto, Claudia C B, Meneses, Elisa A, Diniz, Thiago J, Dionísio, Carlos Ferreira, Santos, Carla R, Sipert   +5 more
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Profiling the Secretome of Human Stem Cells from Dental Apical Papilla

Stem Cells and Development, 2016
Recent studies have shown that secretion of bioactive factors from mesenchymal stem cells (MSCs) plays a primary role in MSC-mediated therapy; especially for bone marrow-derived MSCs (BMSCs). MSCs from dental apical papilla (SCAPs) are involved in root development and may play a critical role in the formation of dentin and pulp.
Shi, Yu, Yuming, Zhao, Yushi, Ma, Lihong, Ge   +3 more
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Effect of Bacterial Biofilm on the Osteogenic Differentiation of Stem Cells of Apical Papilla

Journal of Endodontics, 2017
Although clinical success in regenerative endodontics is substantially high, histological success is limited to finding bone/cementum-like tissue instead of dentin within the canal space. The aims of this study were to investigate (1) the effect of bacterial biofilm on osteogenic gene expression in stem cells of the apical papilla (SCAP) and (2) the ...
Lakshmi, Vishwanat, Rose, Duong, Koyo, Takimoto, Linda, Phillips, Claudia O, Espitia, Anibal, Diogenes, Shivani B, Ruparel, David, Kolodrubetz, Nikita B, Ruparel   +8 more
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Role of CPNE1 in Odontoblastic Differentiation of Rat Stem Cells from Apical Papilla

Advanced Biology, 2023
AbstractCPNE1 is a calcium‐dependent, phospholipid‐binding protein that is ubiquitously expressed in various tissues and organs. This study investigates the expression and localization of CPNE1 in tooth germ development and the role of CPNE1 in odontoblastic differentiation.
Xi Lu, Han Xie, Yanqin Ju, Yunyu Fu, Shangfeng Liu, Shouliang Zhao   +5 more
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Endocannabinoids Modulate Production of Osteoclastogenic Factors by Stem Cells of the Apical Papilla In Vitro

Journal of Endodontics, 2022
Many mediators are produced during pulp inflammation and necrosis, including endocannabinoids (ECbs), which might affect the function of stem cells of the apical papilla (SCAP), cells of paramount importance for root formation, and regenerative endodontic treatment.
Claudia Caroline Bosio Meneses, Anibal R. Diogenes, Carla Renata Sipert   +2 more
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Apical Papilla Regulates Dental Follicle Fate via the OGN-Hh Pathway

Journal of Dental Research, 2022
Root apical complex, including Hertwig’s epithelial root sheath, apical papilla, and dental follicle (DF), is the germinal center of root development, wherein the DF constantly develops into periodontal tissue. However, whether DF development is regulated by the adjacent apical papilla remains largely unknown.
X. Lin, Q. Li, L. Hu, C. Jiang, S. Wang, X. Wu   +5 more
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Fibrin Hydrogels to Deliver Dental Stem Cells Of the Apical Papilla for Regenerative Medicine

Regenerative Medicine, 2015
Evaluation of survival, proliferation and neurodifferentiation of dental stem cells from the apical papilla (SCAP) in fibrin hydrogels. We hypothesized that fibrin composition will influence cell behavior.Modulus, pore and fiber size were measured. SCAP in vitro viability, proliferation and neural differentiation, as well as in vivo proliferation and ...
Germain, Loïc, De Berdt, Pauline, Vanacker, Julie, Leprince, Julian Grégoire, Diogenes, Anibal, Jacobs, Damien, Vandermeulen, Gaëlle, Bouzin, Caroline, Préat, Véronique, Dupont-Gillain, Christine, des Rieux, Anne   +10 more
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