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Apical Papilla Regulates Dental Follicle Fate via the OGN-Hh Pathway
Journal of Dental Research, 2022Root apical complex, including Hertwig’s epithelial root sheath, apical papilla, and dental follicle (DF), is the germinal center of root development, wherein the DF constantly develops into periodontal tissue. However, whether DF development is regulated by the adjacent apical papilla remains largely unknown.
X. Lin +5 more
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Dental pulp and apical papilla cells senescence: causes, consequences, and prevention
Biogerontology, 2023Dental pulp under physiological conditions has a defense function, repair capacity, and important mechanisms in pathological processes. In addition, the dental papilla is involved in important defense processes and an essential function in the pulp revascularization process.
Jade Ormondes de Farias +1 more
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Hormesis and dental apical papilla stem cells
Chemico-Biological Interactions, 2022This paper provides an assessment of hormetic dose responses by stem cells of the apical papilla (SCAPs) from humans. Hormetic dose responses were induced in vitro by a broad range of agents, including dietary supplements (e.g., berberine, EGCG, resveratrol), pharmaceutical/commercial substances (e.g.
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Dental Apical Papilla as Therapy for Spinal Cord Injury
Journal of Dental Research, 2015Stem cells of the apical papilla (SCAP) represent great promise regarding treatment of neural tissue damage, such as spinal cord injury (SCI). They derive from the neural crest, express numerous neurogenic markers, and mediate neurite outgrowth and axonal targeting.
De Berdt, P +7 more
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Effects of serum-free culture media on human apical papilla cells properties
Archives of Oral Biology, 2021Aiming at more effective and safer cell therapies, the objective of this study was to evaluate the biological properties of human apical papilla cells cultured in the absence of serum supplementation in comparison to cells cultured with fetal bovine serum (FBS).Two apical papilla cell populations were isolated from third molars with incomplete ...
Aline, Queiroz +4 more
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Overexpression of ephrinB2 in stem cells from apical papilla accelerates angiogenesis
Oral Diseases, 2019AbstractObjectivesWe aimed to accelerate angiogenesis in pulp regeneration by modulating ephrinB2 expression in stem cells from apical papilla (SCAPs).Materials and MethodsStem cells from apical papilla were transducted with ephrinB2‐lentiviral expression vector (ephrinB2‐SCAPs) in experimental group and green fluorescent protein (GFP‐SCAPs) in control
Changyong Yuan +8 more
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Angiotensin II Regulates Proliferation and Function of Stem Cells of Apical Papilla
Journal of Endodontics, 2020Stem cells of apical papilla (SCAP) may be affected by inflammatory mediators released by activation with lipopolysaccharide (LPS) from infected pulpal cavities of necrotic immature teeth. Therefore, this study aimed to investigate the presence of a local renin-angiotensin system (RAS) and the role of angiotensin II (Ang II) on the modulation of SCAP ...
Lais Nicolay, Pizzatto +5 more
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Profiling the Secretome of Human Stem Cells from Dental Apical Papilla
Stem Cells and Development, 2016Recent studies have shown that secretion of bioactive factors from mesenchymal stem cells (MSCs) plays a primary role in MSC-mediated therapy; especially for bone marrow-derived MSCs (BMSCs). MSCs from dental apical papilla (SCAPs) are involved in root development and may play a critical role in the formation of dentin and pulp.
Shi, Yu +3 more
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Proteomic profile of human dental follicle stem cells and apical papilla stem cells
Journal of Proteomics, 2021Dental stem cells have great potential in clinical practice as an adult mesenchymal stem cell, such as dental follicle and the apical papilla, have strong proliferation and differentiation characteristics. The developmental relevance and discrimination of them in the niche is not clear, which limits their application scenarios.
Tong, Lei +4 more
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Role of CPNE1 in Odontoblastic Differentiation of Rat Stem Cells from Apical Papilla
Advanced Biology, 2023AbstractCPNE1 is a calcium‐dependent, phospholipid‐binding protein that is ubiquitously expressed in various tissues and organs. This study investigates the expression and localization of CPNE1 in tooth germ development and the role of CPNE1 in odontoblastic differentiation.
Xi Lu +5 more
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