Results 1 to 10 of about 8,460 (160)
APOBECs and Herpesviruses [PDF]
Viruses, 2021 The apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like (APOBEC) family of DNA cytosine deaminases provides a broad and overlapping defense against viral infections.
Adam Z. Cheng +8 more
doaj +3 more sources
Machine learning-driven classification and prognostic prediction of kidney renal clear cell carcinoma using APOBEC family expression signatures [PDF]
Scientific ReportsApolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like (APOBEC) cytidine deaminases are a highly evolutionarily conserved protein family. Their members are closely associated with DNA damage repair and involved in the genesis and progression of
Zhen Ren +15 more
doaj +2 more sources
APOBEC in breast cancer: a dual player in tumor evolution and therapeutic response [PDF]
Frontiers in Molecular BiosciencesThe APOBEC (Apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like) family of cytidine deaminases has emerged as pivotal a contributor to genomic instability and adaptive immunity through DNA/RNA editing. Accumulating evidence underscores their
Haiqi Lu +5 more
doaj +2 more sources
Comprehensive Insights into APOBEC Mutations in Thyroid Cancer: Prognostic and Therapeutic Discoveries [PDF]
Biological Procedures OnlineBackground The APOBEC (apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like) family plays a vital mutagenic role in diverse human malignancies.
Wei Luo +15 more
doaj +2 more sources
Characterization of a synthetic infectious cloned DNA of simian foamy virus serotype 1 [PDF]
npj VirusesA virus stock of a cloned infectious DNA of simian foamy virus serotype 1 (SFV-1) was obtained in M. dunni cells (designated as pSFV-MD). The kinetics of replication were similar to the parent uncloned SFV-MD stock in M.
Sandra M. Fuentes +4 more
doaj +2 more sources
Genomic characterization of tumor mutational burden-high breast carcinomas [PDF]
npj Precision OncologyTumor mutational burden (TMB) has emerged as a potential surrogate for neoantigen load and an indicator of immune checkpoint (IC)-blockade response; however, its precise significance in breast cancer (BC) is not fully understood. Here, we comprehensively
Theodore Vougiouklakis +10 more
doaj +2 more sources
Viruses, 2021 APOBEC is a mutagenic source in human papillomavirus (HPV)-mediated malignancies, including HPV+ oropharyngeal squamous cell carcinoma (HPV + OPSCC), and in HPV genomes.
Daniel L. Faden +13 more
doaj +1 more source
SARS-CoV-2 variants： origin， drivers and prevention measures
Shanghai yufang yixue, 2022 COVID-19 has emerged around the world since December 2019 and rapidly evolves as a major global public health challenge. SARS-CoV-2 is a positive single-stranded RNA virus with a relatively high natural mutation rate. The emergence of SARS-CoV-2 variants
SHEN Jiaying +2 more
doaj +1 more source
Heliyon, 2023 Background: APOBEC family play an important role in cancer mutagenesis and tumor development. The role of APOBEC family in lung adenocarcinoma (LUAD) has not been studied comprehensively.
Yu Luo +6 more
doaj +1 more source
APOBEC-1 deletion enhances cisplatin-induced acute kidney injury
Scientific Reports, 2023 Cisplatin (CP) induces acute kidney injury (AKI) whereby proximal tubules undergo regulated necrosis. Repair is almost complete after a single dose. We now demonstrate a role for Apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 (Apobec-1 ...
Xiaojia Guo +8 more
doaj +1 more source