Results 11 to 20 of about 8,460 (160)
The Role of APOBECs in Viral Replication [PDF]
Microorganisms, 2020 Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like (APOBEC) proteins are a diverse and evolutionarily conserved family of cytidine deaminases that provide a variety of functions from tissue-specific gene expression and immunoglobulin ...
Wendy Kaichun Xu +2 more
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HIV-1 Vif, APOBEC, and Intrinsic Immunity [PDF]
Retrovirology, 2008 Members of the APOBEC family of cellular cytidine deaminases represent a recently identified group of proteins that provide immunity to infection by retroviruses and protect the cell from endogenous mobile retroelements.
Strebel Klaus, Goila-Gaur Ritu
doaj +3 more sources
The current toolbox for APOBEC drug discovery [PDF]
Trends in Pharmacological Sciences, 2022 Mutational processes driving genome evolution and heterogeneity contribute to immune evasion and therapy resistance in viral infections and cancer. APOBEC3 (A3) enzymes promote such mutations by catalyzing the deamination of cytosines to uracils in single-stranded DNA.
Michael J. Grillo +4 more
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APOBEC‐1‐mediated RNA editing [PDF]
WIREs Systems Biology and Medicine, 2010 AbstractRNA editing defines a molecular process by which a nucleotide sequence is modified in the RNA transcript and results in an amino acid change in the recoded message from that specified in the gene. We will restrict our attention to the type of RNA editing peculiar to mammals, i.e., nuclear C to U RNA editing.
Valerie, Blanc, Nicholas O, Davidson
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APOBEC3 as a driver of genetic intratumor heterogeneity
Molecular & Cellular Oncology, 2021 Our recent study revealed that APOBEC3B is upregulated during the preinvasive stages of non-small cell lung cancer and breast cancer. In addition to its role in mediating single nucleotide variants, we propose that APOBEC3 promotes copy number intratumor
Subramanian Venkatesan +6 more
doaj +1 more source
Special Issue “APOBECs and Virus Restriction” [PDF]
Viruses, 2021 The apolipoprotein B mRNA editing enzyme, catalytic polypeptide (APOBEC) enzyme family in humans has 11 members with diverse functions in metabolism and immunity [...]
openaire +3 more sources
Genome Medicine, 2020 Background APOBEC-driven mutagenesis and functional positive selection of mutated genes may synergistically drive the higher frequency of some hotspot driver mutations compared to other mutations within the same gene, as we reported for FGFR3 S249C. Only
Ming-Jun Shi +5 more
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Transient and tunable CRISPRa regulation of APOBEC/AID genes for targeting hepatitis B virus
Molecular Therapy: Nucleic Acids, 2023 APOBEC/AID cytidine deaminases play an important role in innate immunity and antiviral defenses and were shown to suppress hepatitis B virus (HBV) replication by deaminating and destroying the major form of HBV genome, covalently closed circular DNA ...
Dmitry Kostyushev +15 more
doaj +1 more source
AID/APOBEC deaminases and cancer [PDF]
Oncoscience, 2015 Mutations are the basis for evolution and the development of genetic diseases. Especially in cancer, somatic mutations in oncogenes and tumor suppressor genes alongside the occurrence of passenger mutations have been observed by recent deep-sequencing approaches.
Stefan, Rebhandl +3 more
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Sensitive detection systems for infectious agents in xenotransplantation*
Xenotransplantation, EarlyView., 2020 Abstract Xenotransplantation of pig cells, tissues, or organs may be associated with transmission of porcine microorganisms, first of all of viruses, to the transplant recipient, potentially inducing a disease (zoonosis). I would like to define detection systems as the complex of sample generation, sample preparation, sample origin, time of sampling ...
Joachim Denner
wiley +1 more source