Results 71 to 80 of about 8,460 (160)

Interplay between RNA‐protein interactions and RNA structures in gene regulation

FEBS Open Bio, Volume 16, Issue 2, Page 299-313, February 2026.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko, Mauro Scaravilli, Minna‐Liisa Änkö   +2 more
wiley   +1 more source

Proteogenomic Characterization Reveals Subtype‐Specific Therapeutic Potential for HER2‐Low Breast Cancer

Advanced Science, Volume 13, Issue 12, 27 February 2026.
Multiomic profiling of HER2‐low breast cancer identifies three proteomic subtypes with distinct therapeutic strategies: endocrine, antiangiogenic, and anti‐HER2 therapies. Genomic and lactate modification landscapes are detailed, providing insights for precise management.
Shouping Xu, Keda Yu, Lei Liu, Qin Wang, Xiaohui Wu, Yihai Chen, Guozheng Li, Xin Zhang, Bo Wei, Zitong Fu, Abiyasi Nanding, Zuxianglan Zhao, Lingbing Yang, Xingda Zhang, Jianyu Wang, Wantong Sun, Yi Hao, Zhongyi Cheng, Xiaojiang Cui, Hao Wu, Da Pang   +20 more
wiley   +1 more source

A Novel RNA Editing Sensor Tool and a Specific Agonist Determine Neuronal Protein Expression of RNA-Edited Glycine Receptors and Identify a Genomic APOBEC1 Dimorphism as a New Genetic Risk Factor of Epilepsy

Frontiers in Molecular Neuroscience, 2018
C-to-U RNA editing of glycine receptors (GlyR) can play an important role in disease progression of temporal lobe epilepsy (TLE) as it may contribute in a neuron type-specific way to neuropsychiatric symptoms of the disease.
Svenja Kankowski, Benjamin Förstera, Aline Winkelmann, Pina Knauff, Erich E. Wanker, Xintian A. You, Marcus Semtner, Florian Hetsch, Jochen C. Meier   +8 more
doaj   +1 more source

MagnEdit—interacting factors that recruit DNA-editing enzymes to single base targets

Life Science Alliance, 2020
This study reports a new, non-covalent strategy—called MagnEdit—that attracts the DNA cytosine deaminase APOBEC3B to a Cas9-directed site for C-to-T editing.
Jennifer L McCann, Daniel J Salamango, Emily K Law, William L Brown, Reuben S Harris   +4 more
doaj   +1 more source

Predictors of discontinuing injectable cabotegravir/rilpivirine and virologic outcomes after resuming oral antiretroviral therapy

HIV Medicine, Volume 27, Issue 2, Page 217-225, February 2026.
Abstract Objective Evaluate factors associated with discontinuation of long‐acting injectable (LAI) cabotegravir/rilpivirine (CAB/RPV) and describe virologic outcomes in those that returned to oral antiretroviral therapy (ART). Methods This is a retrospective cohort study at a single‐centre primary care HIV clinic.
Tali Faggiano, Jeffrey Yin, Nimish Patel, Afsana Karim, Kari Abulhosn, Laura Bamford, Lucas Hill   +6 more
wiley   +1 more source

Sex differences in the clinical presentation of patients with newly diagnosed multiple myeloma

Cancer, Volume 132, Issue 2, 15 January 2026.
Abstract Introduction Standardized incidence rates of multiple myeloma (MM) are higher among males than females, suggesting that male sex is an important risk factor for MM, which may affect disease etiology, pathogenesis, and clinical presentation. Methods The association of sex with the prevalence of clinical features and chromosomal abnormalities ...
Krystle L. Ong, Kevin D. Arnold, Meredith C. Wessel, Gayatri Ravi, Faith E. Davies, Gareth J. Morgan, Elizabeth E. Brown   +6 more
wiley   +1 more source

AID and APOBECs span the gap between innate and adaptive immunity

Frontiers in Microbiology, 2014
The AID/APOBEC cytidine deaminases participate in a diversity of biological processes from the regulation of protein expression to embryonic development and host defenses. In its classical role, AID mutates germline-encoded sequences of B cell receptors,
Arnaud eMoris, Shannon M Murray, Sylvain eCardinaud   +2 more
doaj   +1 more source

5‐Hydroxymethylcytosine Dynamics Reveals Coordinated Reprogramming of Parental Genomes and X Chromosome Dosage Balance in Mouse SCNT Embryos

Advanced Science, Volume 13, Issue 6, 30 January 2026.
Genome‐wide, high‐resolution profiling of hydroxymethylation in mouse SCNT embryos reveals a transient, allele‐symmetric 5hmC reprogramming pattern distinct from natural embryos, with X‐chromosomes and imprinting control regions resistant to proper remodeling.
Zeming Xiang, Rui Yan, Jing Guo, Mengyao Wang, Xin Cheng, Fan Zhang, Tianzi Guo, Xin Long, Fan Guo, Dan Liang   +9 more
wiley   +1 more source

Identification of HIV-1 Vif Protein Attributes Associated With CD4 T Cell Numbers and Viral Loads Using Artificial Intelligence Algorithms

IEEE Access, 2020
The Human Immunodeficiency Virus (HIV) Viral Infectivity Factor (Vif) is a 192-amino acid accessory protein essential to viral replication which counteracts host APOBEC3 proteins. APOBEC3 proteins interfere with the replication of HIV, hepatitis C virus,
Jose S. Altamirano-Flores, Sandra E. Guerra-Palomares, Pedro G. Hernandez-Sanchez, Jose L. Ramirez-Garcialuna, J. Rafael Arguello-Astorga, Daniel E. Noyola, Juan C. Cuevas-Tello, Christian A. Garcia-Sepulveda   +7 more
doaj   +1 more source

Biological age acceleration associates with Alzheimer's disease plasma biomarker levels

Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.
Abstract INTRODUCTION Epigenetic clocks associate with neuropathology and Alzheimer's disease (AD) clinical risk, but findings are mixed regarding whether clocks associate with blood‐based biomarkers and in non‐European populations. METHODS We calculated biological age and age acceleration from blood methylation data in 704 older Hispanic adults and ...
Jaclyn M. Eissman, Yiyi Ma, Min Qiao, Dolly Reyes‐Dumeyer, Angel Piriz, Annie J. Lee, Rafael A. Lantigua, Martin Medrano, Diones Rivera Mejia, Lawrence S. Honig, Francine Grodstein, David A. Bennett, Philip L. De Jager, Clifton L. Dalgard, Richard Mayeux, Badri N. Vardarajan   +15 more
wiley   +1 more source