Results 81 to 90 of about 7,631 (195)
Host Restriction of Lentiviruses and Viral Countermeasures: APOBEC3 and Vif
Viruses, 2013 It is becoming increasingly clear that organisms have developed a variety of mechanisms to fight against viral infection. The viruses have developed means of counteracting these defences in various ways.
Valgerdur Andrésdóttir +1 more
doaj +1 more source
The Role of APOBEC3B in Cancer: Mechanisms, Clinical Challenges, and Therapeutic Opportunities
Human Mutation, Volume 2026, Issue 1, 2026.Apolipoprotein B mRNA editing enzyme catalytic polypeptide‐like 3B (APOBEC3B, A3B) is a key cytidine deaminase that induces genomic instability and clonal evolution in diverse malignancies. Although A3B plays a key role in the onset and advancement of various cancers, a comprehensive model bridging its multifaceted mechanisms and clinical translation ...
Fengfeng Zhou +3 more
wiley +1 more source
Fv1 restriction and retrovirus vaccine immunity in Apobec3-deficient 129P2 mice. [PDF]
PLoS ONE, 2013 Understanding the host genetics of the immune response in retrovirus infection models could provide insights for basic HIV vaccine discovery. In Friend retrovirus (FV) infection of mice, Fv1 differentially inhibits N-tropic versus B-tropic FV infection ...
Kalani Halemano +6 more
doaj +1 more source
Progressive APOBEC3B mRNA expression in distant breast cancer metastases [PDF]
, 2017 __Background:__ APOBEC3B was recently identified as a gain-of-function enzymatic source of mutagenesis, which may offer novel therapeutic options with molecules that specifically target this enzyme.
Dalm, S.U. (Simone) +8 more
core +1 more source
Antiviral defense by APOBEC3 Family Proteins
Uirusu, 2005 APOBEC3G is a potent antiretroviral factor, which belongs to the APOBEC superfamily of cytidine deaminases. It deaminates cytidine to uridine in nascent minus-strand viral DNA, inducing G-to-A hypermutation in the plus-strand viral DNA. HIV-1 Vif protein overcomes the antiviral activity of APOBEC3G by targeting it for ubiquitin-dependent degradation ...
openaire +3 more sources
Diagnostics, 2023 The association between mouse mammary tumor virus (MMTV)-like sequences and human breast cancer (BC) is largely documented in the literature, but further research is needed to determine how they influence carcinogenesis.
Nathália de Sousa Pereira +2 more
doaj +1 more source
Modellezés a HIV-fertőzés kutatásában és az immunológiában = Mathematical modelling in the study of HIV infection and immunology [PDF]
, 2008 A publikált eredményeket összegzem röviden. 1. Összehasonlító genomanalízis segítségével megvizsgáltam, hogy a retrovírusok genomösszetételét mennyiben befolyásolhatta a nemrég felfedezett APOBEC3 enzimcsalád, amely guanin->adenin hipermutációt ...
Müller, Viktor
core
Organoid Models to Study Human Infectious Diseases
Cell Proliferation, Volume 58, Issue 11, November 2025.Our manuscript reviews the role of organoids as models for studying human infectious diseases, highlighting their irreplaceable contributions to drug testing and vaccine development for significant infectious diseases including HIV, ZIKV, SARS‐CoV‐2 and MPXV.
Sijing Zhu +4 more
wiley +1 more source
Expression of APOBEC3 Lentiviral Restriction Factors in Cats [PDF]
Viruses, 2019 Feline immunodeficiency virus (FIV) is a naturally occurring T-cell tropic lentiviral disease of felids with many similarities to HIV/AIDS in humans. Similar to primate lentiviral-host interactions, feline APOBEC3 (A3) has been shown to inhibit FIV infection in a host-specific manner and feline A3 degradation is mediated by FIV Vif.
Ryan M. Troyer +7 more
openaire +3 more sources
Scientific Reports, 2023 Since November 2019, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused the worldwide pandemic of the coronavirus disease 2019 (COVID-19), the impact of which is huge to the lives of world populations.
Ke Zhang +7 more
doaj +1 more source