Results 21 to 30 of about 2,476,611 (401)

Apolipoprotein A-I modulates HDL particle size in the absence of apolipoprotein A-II [PDF]

Journal of Lipid Research, 2021
Human high-density lipoproteins (HDLs) are a complex mixture of structurally related nanoparticles that perform distinct physiological functions. We previously showed that human HDL containing apolipoprotein A-I (APOA1) but not apolipoprotein A-II (APOA2), designated LpA-I, is composed primarily of two discretely sized populations.
Scott E. Street, Jere P. Segrest, John T. Melchior, John T. Melchior, Zsuzsanna Kuklenyik, Shimpi Bedi, Jay W. Heinecke, Noemie Clouet-Foraison, Rachel Hart, Tomas Vaisar, Amy S. Shah, Jay Jerome, Carissa Thornock, W. Sean Davidson   +13 more
openaire   +4 more sources

Apolipoprotein A-I Supports MSCs Survival under Stress Conditions

International Journal of Molecular Sciences, 2020
Clinical trials have shown the safety of mesenchymal stem/stromal cells (MSCs) transplantation, but the effectiveness of these treatments is limited. Since, transplanted MSCs will undergo metabolic disturbances in the bloodstream, we investigated the ...
S. Miroshnichenko, I. Usynin, Alexey Dudarev, V. Nimaev, A. Solovieva   +4 more
semanticscholar   +1 more source

Hypertriglyceridemia promotes dysfunctions in high-density lipoprotein increasing the cardiovascular risk

Brazilian Journal of Pharmaceutical Sciences, 2023
Hypertriglyceridemia is associated with several metabolic diseases. The triglycerides (TG) disrupt the cholesterol reverse transport and contribute to increased levels of low-density lipoprotein (LDL).
Richard Rarison Cavalcante Meneses, Nágila Raquel Teixeira Damasceno, Flávia De Conti Cartolano, Sara Maria Moreira Lima Verde, Letícia Gomes Lira, Mariana Brito Dantas, Glautemberg de Almeida Viana, Mateus Edson da Silva, Ederson Laurindo Holanda de Sousa, Gdayllon Cavalcante Meneses, Jamile Magalhães Ferreira, Tiago Lima Sampaio, Maria Goretti Rodrigues de Queiroz   +12 more
doaj   +1 more source

Apolipoprotein A-I Mimetic Peptides [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2005
Despite identical amino acid composition, differences in class A amphipathic helical peptides caused by differences in the order of amino acids on the hydrophobic face results in substantial differences in antiinflammatory properties. One of these peptides is an apolipoprotein A-I (apoA-I) mimetic, D-4F.
Victor Grijalva, Mohamad Navab, Geeta Datta, Gattadahalli M. Anantharamaiah, Susan Hama, Nicholas Yu, Srinivasa T. Reddy, Greg Hough, David W. Garber, Alan M. Fogelman, Benjamin J. Ansell   +10 more
openaire   +3 more sources

An Apolipoprotein A-I Mimetic Works Best in the Presence of Apolipoprotein A-I [PDF]

Circulation Research, 2005
See related article, pages 1190–1197 Ou et al1 report that an apolipoprotein A-I (apoA-I) mimetic peptide, D-4F, reduced wall thickness and improved vasoreactivity in the fascialis artery (internal diameter 180 to 240 μm) in low-density lipoprotein (LDL) receptor–null mice on a Western diet.
Alan M. Fogelman, Mohamad Navab, Gattadahalli M. Anantharamaiah   +2 more
openaire   +2 more sources

Correlation between Pretreatment Serum Apolipoprotein Level and Prognosis of Small Cell Lung Cancer Patients

Chinese Journal of Lung Cancer, 2020
Background and objective Lung cancer is the leading cause of cancer-related death, and small cell lung cancer (SCLC) has a poor prognosis in all types of lung cancer.
Ya DONG, Haocheng WANG, Dongfeng SHAN, Linwei ZHANG, Zhuang YU   +4 more
doaj   +1 more source

Transport of apolipoproteins A-I and A-II by human thoracic duct lymph [PDF]

, 1981
The daily transport of human plasma apolipoproteins A-I and A-II, triglyceride, and total cholesterol from the thoracic duct lymph into plasma was measured in 2 subjects before and 3 subjects after renal transplantation. Lymph triglyceride transport was ~
Anderson, DW, Brewer, HB, Bronzert, TJ, Forte, T, Lindgren, FT, Niblack, GD, Schaefer, EJ, Starzl, TE, Zech, LA   +8 more
core   +1 more source

Apolipoprotein A-I mimetic peptides [PDF]

Current Atherosclerosis Reports, 2008
Recent publications reveal the mechanism of action of apolipoprotein A-I (apoA-I) mimetic peptides to be the remarkable binding affinity that oxidized lipids have for these peptides compared with apoA-I. There was no difference in the binding affinity of oxidized lipids or in peptide efficacy in reducing inflammation and atherosclerosis in rabbits ...
Mohamad Navab, Srinivasa T. Reddy, Alan M. Fogelman, Brian J. Van Lenten, Georgette M. Buga, Alan C. Wagner, Gattadahalli M. Anantharamaiah   +6 more
openaire   +2 more sources

Binding of apolipoprotein A-I and acetaldehyde-modified apolipoprotein A-I to liver extracellular matrix [PDF]

Hepatology, 1996
Apolipoprotein A-I (Apo A-I), a protein produced mainly by hepatocytes, is decreased in the sera of alcoholic patients with liver fibrosis and cirrhosis. To explain this decrease, we investigated possible interactions between liver extracellular matrix (ECM) and Apo A-I.
Philippe Mathurin, Pierre Bedossa, Valérie Paradis, Thierry Poynard, V. Ratziu   +4 more
openaire   +4 more sources

Apolipoprotein A-I (ApoA-I), Immunity, Inflammation and Cancer

Cancers, 2019
Apolipoprotein A-I (ApoA-I), the major protein component of high-density lipoproteins (HDL) is a multifunctional protein, involved in cholesterol traffic and inflammatory and immune response regulation. Many studies revealing alterations of ApoA-I during
K. Georgila, Dimitra Vyrla, E. Drakos
semanticscholar   +1 more source