Results 21 to 30 of about 92,863 (145)

Probing the Structure–Function relationship and amyloidogenic propensities in natural variants of apolipoprotein A-I

Biochemistry and Biophysics Reports, 2020
Background: Apolipoprotein A-I (apoA-I) protects against atherosclerosis and participates in the removal of excess cellular cholesterol from peripheral organs. Several naturally occurring apoA-I mutations are associated with familial systemic amyloidosis,
Farah Ma'arfi, Subhash Chandra Prasad, Jamal e Fatima, Mohd Yasir Khan, Snober S. Mir, Mohd Aslam Yusuf   +5 more
doaj   +1 more source

Binding of apolipoprotein A-I and acetaldehyde-modified apolipoprotein A-I to liver extracellular matrix [PDF]

Hepatology, 1996
Apolipoprotein A-I (Apo A-I), a protein produced mainly by hepatocytes, is decreased in the sera of alcoholic patients with liver fibrosis and cirrhosis. To explain this decrease, we investigated possible interactions between liver extracellular matrix (ECM) and Apo A-I.
V, Paradis, P, Mathurin, V, Ratziu, T, Poynard, P, Bedossa   +4 more
openaire   +3 more sources

Volumetric determination of apolipoprotein stoichiometry of circulating HDL subspecies1[S]

Journal of Lipid Research, 2013
Although HDL is inversely correlated with coronary heart disease, elevated HDL-cholesterol is not always protective. Additionally, HDL has biological functions that transcend any antiatherogenic role: shotgun proteomics show that HDL particles contain 84
Jere P. Segrest, Marian C. Cheung, Martin K. Jones   +2 more
doaj   +1 more source

Serum apolipoproteins in relation to intakes of fish in population of Arkhangelsk County

Nutrition & Metabolism, 2012
Background Diets rich in omega-3 fatty acids and low in saturated fat were found beneficially associated with blood lipids and cardio-vascular health. Lean reindeer meet and local cold water white-fish species high in omega-3 are among the main sources ...
Petrenya Natalia, Brustad Magritt, Cooper Marie, Dobrodeeva Liliya, Bichkaeva Fatima, Lutfalieva Gulnara, Odland Jon   +6 more
doaj   +1 more source

ApoA-I cleaved by transthyretin has reduced ability to promote cholesterol efflux and increased amyloidogenicity

Journal of Lipid Research, 2007
A fraction of plasma transthyretin (TTR) circulates in HDL through binding to apolipoprotein A-I (apoA-I). Moreover, TTR is able to cleave the C terminus of lipid-free apoA-I.
Márcia Almeida Liz, Cláudio M. Gomes, Maria João Saraiva, Mónica Mendes Sousa   +3 more
doaj   +1 more source

The age-related paraoxonase 1 response is altered by long-term caloric restriction in male and female rats

Journal of Lipid Research, 2006
Caloric restriction (CR) has been shown to attenuate age-related oxidative damage and to improve major atherosclerotic risk factors. Paraoxonase 1 (PON1), an enzyme specifically associated with HDL containing apolipoproteins A-I and J, has been reported ...
Elena Thomàs-Moyà, Magdalena Gianotti, Ana M. Proenza, Isabel Lladó   +3 more
doaj   +1 more source

Effect of urotensin II on apolipoprotein B 100 and apolipoprotein A-I expression in HepG2 cell line

Advanced Biomedical Research, 2014
Background: Increased apolipoprotein B100 (apo B) and decreased apolipoprotein A-I (apo A-I) production are important risk factors in atherosclerosis.
Abbas Mohammadi, Ahmad Gholamhoseinian Najar, Amirhosein Khoshi   +2 more
doaj   +1 more source

Evaluation of Lipid Profile, Apo B/ Apo A Ratio and Lpa and its Relationship with Cognitive Disorders in the Older Adults: Birjand Longitudinal Aging Study

Archives of Advances in Biosciences, 2023
Introduction: Accurate and timely diagnosis of mild cognitive disorders is essential to prevent their progression to dementia. This study aimed to determine the relationship among the serum levels of lipid markers of cognitive disorders in older adults ...
Sara Hamdamian, Asghar Zarban , Mitra Moodi, Farshad Sharifi, rasoul raesi, Mohammad Dehghani Firoozabadi   +5 more
doaj   +1 more source

Characterization of four lipoprotein classes in human cerebrospinal fluid

Journal of Lipid Research, 2001
Lipoprotein metabolism in brain has not yet been fully elucidated, although there are a few reports concerning lipids in the brain and lipoproteins and apolipoproteins in the cerebrospinal fluid (CSF).
Stefanie Koch, Nicolette Donarski, Kathrin Goetze, Miriam Kreckel, Hans-Joerg Stuerenburg, Carsten Buhmann, Ulrike Beisiegel   +6 more
doaj   +1 more source

Endothelial lipase is less effective at influencing HDL metabolism in vivo in mice expressing apoA-II

Journal of Lipid Research, 2006
Endothelial lipase (EL) plays an important physiological role in modulating HDL metabolism. Data suggest that plasma contains an inhibitor of EL, and previous studies have suggested that apolipoprotein A-II (apoA-II) inhibits the activity of several ...
Uli C. Broedl, Weijun Jin, Ilia V. Fuki, John S. Millar, Daniel J. Rader   +4 more
doaj   +1 more source