Results 21 to 30 of about 25,929 (265)

Cholesterols, Apolipoproteins, and Their Associations with the Presence and Severity of Diabetic Retinopathy: A Systematic Review

Vision, 2022
Serum apolipoproteins have been reported as a more significant marker for diabetic retinopathy (DR) compared with serum cholesterols. This article aims to review the associations between serum cholesterols and apolipoproteins, and the presence and ...
Soefiandi Soedarman, King Hans Kurnia, Alberthus Donni Budi Prasetya, Muhammad Bayu Sasongko   +3 more
doaj   +1 more source

A comprehensive map of single-base polymorphisms in the hypervariable LPA kringle IV type 2 copy number variation region[S]

Journal of Lipid Research, 2019
Lipoprotein (a) [Lp(a)] concentrations are among the strongest genetic risk factors for cardiovascular disease and present pronounced interethnic and interindividual differences.
Stefan Coassin, Sebastian Schönherr, Hansi Weissensteiner, Gertraud Erhart, Lukas Forer, Jamie Lee Losso, Claudia Lamina, Margot Haun, Gerd Utermann, Bernhard Paulweber, Günther Specht, Florian Kronenberg   +11 more
doaj   +1 more source

Multidimensional profiling of plasma lipoproteins by size exclusion chromatography followed by reverse-phase protein arrays

Journal of Lipid Research, 2011
The composition of lipoproteins and the association of proteins with various particles are of much interest in the context of cardiovascular disease. Here, we describe a technique for the multidimensional analysis of lipoproteins and their associated ...
Gregor Dernick, Stefan Obermüller, Cyrill Mangold, Christine Magg, Hugues Matile, Oliver Gutmann, Elisabeth von der Mark, Corinne Handschin, Cyrille Maugeais, Eric J. Niesor   +9 more
doaj   +1 more source

An MRM-Based Multiplexed Quantification Assay for Human Adipokines and Apolipoproteins

Molecules, 2020
Adipokines and apolipoproteins are key regulators and potential biomarkers in obesity and associated diseases and their quantitative assessment is crucial for functional analyses to understand disease mechanisms.
Laura Krieg, Alexandra Schaffert, Matthias Kern, Kathrin Landgraf, Martin Wabitsch, Annette G. Beck-Sickinger, Antje Körner, Matthias Blüher, Martin von Bergen, Kristin Schubert   +9 more
doaj   +1 more source

Degradation of human apolipoprotein B‐100 by apolipoprotein(a)

FEBS Letters, 1993
Human plasma low density lipoproteine (LDL) contain a very high molecular weight protein termed apoB‐100 (M r = 550,000). In many samples of LDL, minor components designated as apoB‐74 (M r = 407,000) and apoB‐26 (M r = 145,000) are present. It has been shown that they can arise as a result of proteolytic degradation of apoB‐100.
Chulkova, T.M., Tertov, V.V.
openaire   +2 more sources

Plasma lipoproteins: apolipoprotein structure and function.

Journal of Lipid Research, 1984
Plasma lipoprotein metabolism is regulated and controlled by the specific apolipoprotein (apo-) constituents of the various lipoprotein classes. The major apolipoproteins include apoE, apoB, apoA-I, apoA-II, apoA-IV, apoC-I, apoC-II, and apoC-III ...
R W Mahley, T L Innerarity, S C Rall, Jr, K H Weisgraber   +3 more
doaj   +1 more source

Lipoprotein (a) and Apolipoproteins in Diabetes and Atherosclerotic Cardiovascular Disease: A Comprehensive Review of the Current Evidence

Diabetology
Atherosclerosis, manifesting as acute myocardial infarction, stroke and peripheral artery disease, is the main cause of death worldwide. Conventional risk factors contributing to the development and progression of atherosclerosis are well established ...
Albion Luzha, Michael Y. Henein, Guxim Bytyçi, Rina Tafarshiku, Gani Bajraktari, Venera Berisha-Muharremi   +5 more
doaj   +1 more source

Mass Spectrometry for the Monitoring of Lipoprotein Oxidations by Myeloperoxidase in Cardiovascular Diseases

Molecules, 2021
Oxidative modifications of HDLs and LDLs by myeloperoxidase (MPO) are regularly mentioned in the context of atherosclerosis. The enzyme adsorbs on protein moieties and locally produces oxidizing agents to modify specific residues on apolipoproteins A-1 ...
Catherine Coremans, Cédric Delporte, Frédéric Cotton, Phillipe Van De Borne, Karim Zouaoui Boudjeltia, Pierre Van Antwerpen   +5 more
doaj   +1 more source

Aqueous Humor Apolipoprotein Concentration and Severity of Diabetic Retinopathy in Type 2 Diabetes

Mediators of Inflammation, 2022
An imbalance of plasma apolipoproteins has been linked to diabetic retinopathy (DR); however, there is scarce information regarding their presence in the aqueous humor (AH) and their role in DR.
Lucia Saucedo, Isabel B. Pfister, Christin Schild, Souska Zandi, Justus G. Garweg   +4 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source