Results 101 to 110 of about 68,358 (287)
DNA-based artificial molecular signaling system that mimics basic elements of reception and response
Nature Communications, 2020 Cells communicate with the outside world to maintain homeostasis. Here the authors design a synthetic biology DNA-based signalling system AMSsys that responds to the presence of ATP.
Ruizi Peng +10 more
doaj +1 more source
Recent Advances in SELEX Technology and Aptamer Applications in Biomedicine
International Journal of Molecular Sciences, 2017 Aptamers are short DNA/RNA oligonucleotides capable of binding to target molecules with high affinity and specificity. The process of selecting an aptamer is called Systematic Evolution of Ligands by Exponential Enrichment (SELEX).
Zhenjian Zhuo +9 more
semanticscholar +1 more source
Advanced Science, EarlyView.Random ssDNA–SWCNT(single strand DNA‐single walled carbon nanotube) library is functionally screened and evolved using high‐throughput 3D prostate tumor spheroids via iterative positive and negative selection, enabling the identification of NIR‐II fluorescent ssDNA‐SWCNT nanoprobe specific for prostate cancer.
Dakyeon Lee +8 more
wiley +1 more source
Advanced Science, EarlyView.Telomerase reverse transcriptase (TERT) mRNA induces DNA self‐assembly in cancer cells, boosting the nanoplatform's magnetothermal properties. This magnetothermia then activates the Hsp70 promoter, initiating siRNA synthesis to silence the TERT gene, enhancing cancer treatment.
Liang Zhang +9 more
wiley +1 more source
Oligonucleotide Functionalised Microbeads: Indispensable Tools for High-Throughput Aptamer Selection
Molecules, 2015 The functionalisation of microbeads with oligonucleotides has become an indispensable technique for high-throughput aptamer selection in SELEX protocols.
Lewis A. Fraser +7 more
doaj +1 more source
Advanced Science, EarlyView.A femtosecond UV pump–probe microscope resolves binding‐induced changes in protein excited‐state dynamics and converts these intrinsic contrasts into an equilibrium affinity readout. By probing tryptophan responses directly in solution, the approach enables quantitative determination of dissociation constants without labeling or immobilization ...
Jianghao Shen +5 more
wiley +1 more source
Oligonucleotide Aptamers: New Tools for Targeted Cancer Therapy
Molecular Therapy: Nucleic Acids, 2014 Aptamers are a class of small nucleic acid ligands that are composed of RNA or single-stranded DNA oligonucleotides and have high specificity and affinity for their targets.
Hongguang Sun +5 more
doaj +1 more source
Asian Pacific Journal of Cancer Biology, 2016 Oligonucleotides Aptamers are single strands of DNA and RNA with the length of 20-100 nucleotides or peptides and unique three dimensional structure that is affected by nucleotide sequence. The structure exclusively influences aptamers’ bindings with its target molecule.
Yazdanpanahi, Nasrin +2 more
openaire +4 more sources
Analytical Chemistry, 2019 Exosomes (Exos) are nanoscale natural vehicles for transporting biomolecules to facilitate cell-to-cell communication, indicating a high potential of them for delivering therapeutics/diagnostics. To improve their delivery capacity, a simple, noninvasive,
Jianmei Zou +6 more
semanticscholar +1 more source
Advanced Science, EarlyView.Glutamine deprivation triggers transient DNA damage yet activates adaptive repair in hepatocellular carcinoma cells. We identify TRIB3 as a stress‐induced nuclear scaffold that associates with DDX5 and G‐quadruplex DNA atBRCA1 andRAD51AP1 promoters. TRIB3 loss increases G4 accumulation, suppresses HR gene transcription, elevates γ‐H2A.X, and sensitizes
Qiang Ji +10 more
wiley +1 more source