Results 11 to 20 of about 68,358 (287)
Angewandte Chemie, 2021 Aptamers are short oligonucleotides isolated in vitro from randomized libraries that can bind to specific molecules with high affinity, and offer a number of advantages relative to antibodies as biorecognition elements in biosensors.
Haixiang Yu +4 more
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Aptamers 101: aptamer discovery and in vitro applications in biosensors and separations
Chemical Science, 2023 Aptamers are single-stranded nucleic acids that bind and recognize targets much like antibodies. Recently, aptamers have garnered increased interest due to their unique properties, including inexpensive production, simple chemical modification, and long ...
Lucy F. Yang +3 more
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SELEX: Critical factors and optimization strategies for successful aptamer selection
Biotechnology and applied biochemistry, 2021 Within the last decade, the application range of aptamers in biochemistry and medicine has expanded rapidly. More than just a replacement for antibodies, these intrinsically structured RNA‐ or DNA‐oligonucleotides show great potential for utilization in ...
Michael Kohlberger, G. Gadermaier
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Recent Progress in Aptamer Discoveries and Modifications for Therapeutic Applications.
ACS Applied Materials and Interfaces, 2020 Aptamers are oligonucleotide sequences with a length of about 25-80 bases which have abilities to bind to specific target molecules that rival those of monoclonal antibodies. They are attracting great attention in diverse clinical translations on account
Shuaijian Ni +14 more
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Aptamer Blocking Strategy Inhibits SARS‐CoV‐2 Virus Infection
Angewandte Chemie, 2021 The COVID‐19 pandemic caused by SARS‐CoV‐2 is threating global health. Inhibiting interaction of the receptor‐binding domain of SARS‐CoV‐2 S protein (SRBD) and human ACE2 receptor is a promising treatment strategy.
Miao Sun +11 more
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Advances in aptamer screening and aptasensors’ detection of heavy metal ions
Journal of Nanobiotechnology, 2021 Heavy metal pollution has become more and more serious with industrial development and resource exploitation. Because heavy metal ions are difficult to be biodegraded, they accumulate in the human body and cause serious threat to human health.
Wenfei Guo +6 more
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Frontiers in Bioengineering and Biotechnology, 2022 Various biosensors based on aptamers are currently the most popular rapid detection approaches, but the performance of these sensors is closely related to the affinity of aptamers.
Yadi Qin +5 more
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Aptamer and aptamer pharmaceuticals [PDF]
SCIENTIA SINICA Chimica, 2018 Recently, molecule-based targeted therapy has achieved remarkable success in clinical, and opened up a new era particulraly in the field of cancer therapy. Monoclonal antibodies and small molecule inhibitors are two pillars of this field. Additionally, a single-strand nucleic acid molecule called “chemical antibody” has also attracted increasing ...
Ting Zheng, Ziyue Ma, Quan Du
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ACS Sensors, 2021 The availability of sensors able to rapidly detect SARS-CoV-2 directly in biological fluids in a single step would allow performing massive diagnostic testing to track in real time and contain the spread of COVID-19. Motivated by this, here, we developed
A. Idili +3 more
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Aptamer-assisted tumor localization of bacteria for enhanced biotherapy
Nature Communications, 2021 Despite bacterial-mediated biotherapies have been widely explored for treating different types of cancer, their implementation has been restricted by low treatment efficacy, due largely to the absence of tumor-specific accumulation following ...
Zhongmin Geng +5 more
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