Results 21 to 30 of about 64,253 (284)
Biosensors, 2017 In the last years, great progress has been accomplished in the development of aptamer sensors with different transducers. In order to improve the sensitivity of these biosensors, several methodologies have been employed. In this Special Issue, the state of art and the future trends in the field of aptamer sensors have been explored.
openaire +4 more sources
Aptamer-iRNAs as Therapeutics for Cancer Treatment
Pharmaceuticals, 2018 Aptamers are single-stranded oligonucleotides (ssDNA or ssRNA) that bind and recognize their targets with high affinity and specificity due to their complex tertiary structure.
Mario M. Soldevilla +3 more
doaj +1 more source
A novel colorimetric biosensor based on non-aggregated Au@Ag core–shell nanoparticles for methamphetamine and cocaine detection [PDF]
, 2017 We report a novel colorimetric biosensor based on non-aggregation Au@Ag core-shell nanoparticles to detect methamphetamine and cocaine. The biosensor consisted of a reporter probe (RP) that is a specific single-stranded DNA (ssDNA) sequence coated on Au ...
Hu, Jiming +5 more
core +1 more source
A Novel PD-L1-targeting Antagonistic DNA Aptamer With Antitumor Effects
Molecular Therapy: Nucleic Acids, 2016 The PD-1/PD-L1 axis is a major pathway involved in tumor immune evasion. Here, we report the novel PD-L1 antagonizing DNA aptamer (aptPD-L1) and demonstrate an integrated pipeline that expedites therapeutic aptamer development. Aptamer can exert antibody-
Wei-Yun Lai +4 more
doaj +1 more source
Integrating microfluidics and biosensing on a single flexible acoustic device using hybrid modes [PDF]
, 2020 Integration of microfluidics and biosensing functionalities on a single device holds promise in continuous health monitoring and disease diagnosis for point-of-care applications.
Dodd, Linzi +10 more
core +5 more sources
Materials Today Bio, 2023 Given the dynamic nature of engineered vascular networks within biofabricated tissue analogues, it is instrumental to have control over the constantly evolving biochemical cues within synthetic matrices throughout tissue remodeling.
Deepti Rana +6 more
doaj +1 more source
Community sewage sensors towards evaluation of drug use trends: detection of cocaine in wastewater with DNA-directed immobilization aptamer sensors [PDF]
, 2016 Illicit drug use has a global concern and effective monitoring and interventions are highly required to combat drug abuse. Wastewater-based epidemiology (WBE) is an innovative and cost-effective approach to evaluate community-wide drug use trends ...
Castrignanò, Erika +4 more
core +1 more source
Three-dimensional modeling of single stranded DNA hairpins for aptamer-based biosensors. [PDF]
, 2017 Aptamers consist of short oligonucleotides that bind specific targets. They provide advantages over antibodies, including robustness, low cost, and reusability.
Jeddi, Iman, Saiz, Leonor
core +2 more sources
Evaluation of the anti-Salmonella Aptamer using Bioinformatic Tools and ELAA Method [PDF]
Research in Molecular Medicine, 2022 Background: Identifying and measuring food pathogens and environmental samples require accurate and high-sensitivity and specific methods. In addition, Salmonella is a zoonotic bacteria that can directly cause human disease.
Fatemeh Bozorgmehr +2 more
doaj
Biosensors, 2022 Nucleic acid aptamer-based research has focused on achieving the highest performance for bioassays. However, there are limitations in evaluating the affinity for the target analytes in these nucleic acid aptamer-based bioassays.
Yejin Park +4 more
doaj +1 more source