Results 21 to 30 of about 68,358 (287)
Enhancement of in vivo targeting properties of ErbB2 aptamer by chemical modification.
PLoS ONE, 2023 Aptamers have great potential for diagnostics and therapeutics due to high specificity to target molecules. However, studies have shown that aptamers are rapidly distributed and excreted from blood circulation due to nuclease degradation.
Jun Young Park +4 more
doaj +1 more source
Pharmaceuticals, 2021 Extracellular vesicles (EVs) have emerged into a novel vaccine platform, a biomarker and a nano-carrier for approved drugs. Their accurate detection and visualization are central to their utility in varied biomedical fields.
Soonjyoti Das +9 more
doaj +1 more source
Generative aptamer discovery using RaptGen
Nature Computational Science, 2022 Nucleic acid aptamers are generated by an in vitro molecular evolution method known as systematic evolution of ligands by exponential enrichment (SELEX). Various candidates are limited by actual sequencing data from an experiment.
Natsuki Iwano +4 more
semanticscholar +1 more source
Biosensors, 2017 In the last years, great progress has been accomplished in the development of aptamer sensors with different transducers. In order to improve the sensitivity of these biosensors, several methodologies have been employed. In this Special Issue, the state of art and the future trends in the field of aptamer sensors have been explored.
openaire +4 more sources
Aptamer-functionalized metal-organic frameworks (MOFs) for biosensing.
Biosensors & bioelectronics, 2020 As a class of crystalline porous materials, metal-organic frameworks (MOFs) have attracted increasing attention. Due to the nanoscale framework structure, adjustable pore size, large specific surface area, and good chemical stability, MOFs have been ...
Mengzhen Lv +6 more
semanticscholar +1 more source
Artificial Intelligence in Aptamer–Target Binding Prediction
International Journal of Molecular Sciences, 2021 Aptamers are short single-stranded DNA, RNA, or synthetic Xeno nucleic acids (XNA) molecules that can interact with corresponding targets with high affinity.
Zihao Chen +6 more
semanticscholar +1 more source
Aptamer-iRNAs as Therapeutics for Cancer Treatment
Pharmaceuticals, 2018 Aptamers are single-stranded oligonucleotides (ssDNA or ssRNA) that bind and recognize their targets with high affinity and specificity due to their complex tertiary structure.
Mario M. Soldevilla +3 more
doaj +1 more source
Angewandte Chemie, 2021 The receptor binding domain (RBD) of the spike glycoprotein of the coronavirus SARS‐CoV‐2 (CoV2‐S) binds to the human angiotensin‐converting enzyme 2 (ACE2) representing the initial contact point for leveraging the infection cascade. We used an automated
A. Schmitz +6 more
semanticscholar +1 more source
Materials Today Bio, 2023 Given the dynamic nature of engineered vascular networks within biofabricated tissue analogues, it is instrumental to have control over the constantly evolving biochemical cues within synthetic matrices throughout tissue remodeling.
Deepti Rana +6 more
doaj +1 more source
Biotechnology Advances, 2019 Aptamers are short single-stranded nucleic acid sequences capable of binding to target molecules in a way similar to antibodies. Due to various advantages such as prolonged shelf life, low batch to batch variation, low/no immunogenicity, freedom to ...
Tao Wang +4 more
semanticscholar +1 more source