Results 31 to 40 of about 68,358 (287)
A Novel PD-L1-targeting Antagonistic DNA Aptamer With Antitumor Effects
Molecular Therapy: Nucleic Acids, 2016 The PD-1/PD-L1 axis is a major pathway involved in tumor immune evasion. Here, we report the novel PD-L1 antagonizing DNA aptamer (aptPD-L1) and demonstrate an integrated pipeline that expedites therapeutic aptamer development. Aptamer can exert antibody-
Wei-Yun Lai +4 more
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Recent Advances in Aptamer Discovery and Applications
Molecules, 2019 Aptamers are short, single-stranded DNA, RNA, or synthetic XNA molecules that can be developed with high affinity and specificity to interact with any desired targets.
Yang Zhang, Bo-Shiun Lai, M. Juhas
semanticscholar +1 more source
Evaluation of the anti-Salmonella Aptamer using Bioinformatic Tools and ELAA Method [PDF]
Research in Molecular Medicine, 2022 Background: Identifying and measuring food pathogens and environmental samples require accurate and high-sensitivity and specific methods. In addition, Salmonella is a zoonotic bacteria that can directly cause human disease.
Fatemeh Bozorgmehr +2 more
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Chemistry & Biology, 2002 A controllable, intracellular RNA aptamer could be an invaluable therapeutic or discovery reagent. A report published in this journal shows that aptamer behavior can be regulated by a small molecule, paving the way for the development of more sophisticated ligand-regulated aptamers.
openaire +2 more sources
A serum-stable RNA aptamer specific for SARS-CoV-2 neutralizes viral entry
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance Developing molecules capable of binding to SARS-CoV-2 spike protein and inhibiting viral infection is of utmost importance for the detection and therapy of COVID-19.
Julián Valero +15 more
semanticscholar +1 more source
Biosensors, 2022 Nucleic acid aptamer-based research has focused on achieving the highest performance for bioassays. However, there are limitations in evaluating the affinity for the target analytes in these nucleic acid aptamer-based bioassays.
Yejin Park +4 more
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, 2018 Aptamers are in vitro selected oligonucleotides capable of specific, high-affinity binding to a wide variety of target molecules. These features enable their application in diagnostics, therapeutics, targeted delivery, fluorescence imaging, and biosensing.
Andrew Brian Kinghorn (Ed.) +2 more
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Immobilization Strategies for Enhancing Sensitivity of Electrochemical Aptamer-Based Sensors.
ACS Applied Materials and Interfaces, 2021 Electrochemical aptamer-based (E-AB) sensors are a versatile sensing platform that can achieve rapid and robust target detection in complex matrices. However, the limited sensitivity of these sensors has impeded their translation from proof-of-concept to
Yingzhu Liu +3 more
semanticscholar +1 more source
Molecular Docking Insight into the Label-Free Fluorescence Aptasensor for Ochratoxin A Detection
Molecules, 2023 Ochratoxin A (OTA) is the most common mycotoxin and can be found in wheat, corn and other grain products. As OTA pollution in these grain products is gaining prominence as a global issue, the demand to develop OTA detection technology has attracted ...
Hua Ye +7 more
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Aptamer-Based Biosensors for Environmental Monitoring
Frontiers in Chemistry, 2020 Due to their relative synthetic and chemical simplicity compared to antibodies, aptamers afford enhanced stability and functionality for the detection of environmental contaminants and for use in environmental monitoring.
E. McConnell, Julie Nguyen, Yingfu Li
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