Results 81 to 90 of about 64,253 (284)
Recent Advances in Aptamer-Based Point-of-Care Testing
SensorsAptamers refer to a class of oligonucleotide probes that have demonstrated remarkable capabilities beyond mere genetic coding, including the unique ability to recognize and selectively bind to specific molecular targets.
Senlin Luo +6 more
doaj +1 more source
Molecular Therapy: Nucleic Acids, 2015 Hepatitis C virus (HCV) is the major cause of progressive liver disease such as chronic hepatitis, cirrhosis, and hepatocellular carcinoma. Previously, we reported that a 29 nucleotide-long 2’-F pyrimidine modified RNA aptamer against the HCV ...
Chang Ho Lee +5 more
doaj +1 more source
DNA-based artificial molecular signaling system that mimics basic elements of reception and response
Nature Communications, 2020 Cells communicate with the outside world to maintain homeostasis. Here the authors design a synthetic biology DNA-based signalling system AMSsys that responds to the presence of ATP.
Ruizi Peng +10 more
doaj +1 more source
Advanced Materials, EarlyView.The study reports a DNA/RNA heteroduplex hydrogel (SeroPTEN‐CG) that undergoes DNase‐mediated hydrogel‐to‐nanogel transition for spinal cord injury therapy by targeting the serotonergic system, combining 5‐hydroxytryptamine (5‐HT)‐mediated excitability restoration to reactivate dormant interneurons with phosphatase and tensin homolog (PTEN)‐targeted ...
Chunlin Li +19 more
wiley +1 more source
Current Research in Structural Biology, 2020 The high-resolution crystal structure of HIV-1 reverse transcriptase (RT) bound to a 38-mer DNA hairpin aptamer with low pM affinity was previously described.
Steve Tuske +11 more
doaj +1 more source
In vitro Selection and Interaction Studies of a DNA Aptamer Targeting Protein A. [PDF]
PLoS ONE, 2015 A new DNA aptamer targeting Protein A is presented. The aptamer was selected by use of the FluMag-SELEX procedure. The SELEX technology (Systematic Evolution of Ligands by EXponential enrichment) is widely applied as an in vitro selection and ...
Regina Stoltenburg +2 more
doaj +1 more source
From aptamer-based biomarker discovery to diagnostic and clinical applications: an aptamer-based, streamlined multiplex proteomic assay [PDF]
, 2010 Recently, we reported an aptamer-based, highly multiplexed assay for the purpose of biomarker identification. To enable seamless transition from highly multiplexed biomarker discovery assays to a format suitable and convenient for diagnostic and life ...
Christopher Bock +10 more
core +1 more source
Selectivity and specificity: pros and cons in sensing [PDF]
, 2016 Sensing using specific and selective receptors provides two very different but complementary strategies. This Sensor Issues article will discuss the merits and challenges of specific sensors, and selective sensors based on synthetic arrays.
Peveler, William J. +2 more
core +2 more sources
Advanced Materials Interfaces, EarlyView.MOFs awaken graphene. MOF‐assisted ultrafast laser writing patterns porous laser‐induced graphene with CuO‐active nanodomains, creating an aptamer‐ready interface for small‐molecule capture. Coupled to an extended‐gate FET, the hybrid converts subtle biochemical binding into a clear electrical signal for resilient cortisol sensing in aqueous media ...
Co Dang Pham +2 more
wiley +1 more source
High throughput sequencing analysis of RNA libraries reveals the influences of initial library and PCR methods on SELEX efficiency. [PDF]
, 2016 The systemic evolution of ligands by exponential enrichment (SELEX) technique is a powerful and effective aptamer-selection procedure. However, modifications to the process can dramatically improve selection efficiency and aptamer performance.
Burnett, John C +6 more
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