Molecular Therapy: Nucleic Acids, 2016 The genetic diversity of the influenza virus hinders the use of broad spectrum antiviral drugs and favors the appearance of resistant strains. Single-stranded DNA aptamers represent an innovative approach with potential application as antiviral compounds.
Paloma Rodriguez +4 more
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Human umbilical cord mesenchymal stem cell-derived exosomes protect renal tubular epithelial cells against tunicamycin-induced apoptosis [PDF]
Xin yixue, 2023 Objective To investigate the role of human umbilical cord mesenchymal stem cell-derived exosomes （hUC-MSC-Exo） in the tunicamycin-induced apoptosis of renal tubular epithelial cells （HKC）.
Lei Yan, Zhan Shihuai, Shi Xiaohua, Yang Lan, Wang Jiawei, Wang Shuiliang, Zhang Shenghang
doaj +1 more source
The identification of single strand DNA aptamers which specifically bind to platelets using cell-SELEX technique [PDF]
The Iranian Journal of Veterinary Science and Technology, 2021 Aptamers are oligonucleotides that can be easily synthesized and bind to their targets with high affinity and specificity. Several aptamers specific to soluble factors of coagulation cascade have been produced, however, aptamers specific to platelet cell
Fatemeh Alemi +4 more
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Aptamers: Potential Diagnostic and Therapeutic Agents for Blood Diseases
Molecules, 2022 Aptamers are RNA/DNA oligonucleotide molecules that specifically bind to a targeted complementary molecule. As potential recognition elements with promising diagnostic and therapeutic applications, aptamers, such as monoclonal antibodies, could provide ...
Maher M. Aljohani +5 more
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Electrochemical Aptasensor for Detection of Dopamine [PDF]
, 2020 This work presents a proof of concept of a novel, simple, and sensitive method of detection of dopamine, a neurotransmitter within the human brain. We propose a simple electrochemical method for the detection of dopamine using a dopamine-specific aptamer
Abu-Ali, Hisham +4 more
core +1 more source
A grafting strategy for the design of improved G-quadruplex aptamers and high-activity DNAzymes. [PDF]
PLoS ONE, 2009 Nucleic acid aptamers are generally obtained by in vitro selection. Some have G-rich consensus sequences with ability to fold into the four-stranded structures known as G-quadruplexes.
Tao Li, Erkang Wang, Shaojun Dong
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Advances in Screening and Development of Therapeutic Aptamers Against Cancer Cells
Frontiers in Cell and Developmental Biology, 2021 Cancer has become the leading cause of death in recent years. As great advances in medical treatment, emerging therapies of various cancers have been developed.
Zheng Li +6 more
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Label-Free, Highly Sensitive Electrochemical Aptasensors Using Polymer-Modified Reduced Graphene Oxide for Cardiac Biomarker Detection [PDF]
, 2020 Acute myocardial infarction (AMI), also recognized as a ???heart attack,??? is one leading cause of death globally, and cardiac myoglobin (cMb), an important cardiac biomarker, is used for the early assessment of AMI.
Bhardwaj, Jyoti +2 more
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PLoS ONE, 2022 BackgroundGrowth Hormone Releasing Hormone (GHRH), 44 amino acids containing hypothalamic hormone, retains the biological activity by its first 29 amino acids.
Burcu Ayhan-Sahin +4 more
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Aptamer-based multiplexed proteomic technology for biomarker discovery [PDF]
, 2010 Interrogation of the human proteome in a highly multiplexed and efficient manner remains a coveted and challenging goal in biology. We present a new aptamer-based proteomic technology for biomarker discovery capable of simultaneously measuring thousands
A Keller +115 more
core +10 more sources