Results 1 to 10 of about 29,754 (236)
Human umbilical cord mesenchymal stem cell-derived exosomes protect renal tubular epithelial cells against tunicamycin-induced apoptosis [PDF]
Xin yixue, 2023 Objective To investigate the role of human umbilical cord mesenchymal stem cell-derived exosomes （hUC-MSC-Exo） in the tunicamycin-induced apoptosis of renal tubular epithelial cells （HKC）.
Lei Yan, Zhan Shihuai, Shi Xiaohua, Yang Lan, Wang Jiawei, Wang Shuiliang, Zhang Shenghang
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The identification of single strand DNA aptamers which specifically bind to platelets using cell-SELEX technique [PDF]
The Iranian Journal of Veterinary Science and Technology, 2021 Aptamers are oligonucleotides that can be easily synthesized and bind to their targets with high affinity and specificity. Several aptamers specific to soluble factors of coagulation cascade have been produced, however, aptamers specific to platelet cell
Fatemeh Alemi +4 more
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Aptamers and aptamer targeted delivery [PDF]
RNA Biology, 2009 When aptamers first emerged almost two decades ago, most were RNA species that bound and tagged or inhibited simple target ligands. Very soon after, the 'selectionologists' developing aptamer technology quickly realized more potential for the aptamer.
Amy C, Yan, Matthew, Levy
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International Journal of Molecular Sciences, 2017 Aptamers are short nucleic acid sequences capable of specific, high-affinity molecular binding. They are isolated via SELEX (Systematic Evolution of Ligands by Exponential Enrichment), an evolutionary process that involves iterative rounds of selection and amplification before sequencing and aptamer characterization.
Andrew Kinghorn +4 more
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Nucleic Acids Research, 2004 The aptamer database is designed to contain comprehensive sequence information on aptamers and unnatural ribozymes that have been generated by in vitro selection methods. Such data are not normally collected in 'natural' sequence databases, such as GenBank.
Jennifer F, Lee +3 more
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Aptamers: Potential Diagnostic and Therapeutic Agents for Blood Diseases
Molecules, 2022 Aptamers are RNA/DNA oligonucleotide molecules that specifically bind to a targeted complementary molecule. As potential recognition elements with promising diagnostic and therapeutic applications, aptamers, such as monoclonal antibodies, could provide ...
Maher M. Aljohani +5 more
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Aptamer and aptamer pharmaceuticals [PDF]
SCIENTIA SINICA Chimica, 2018 Recently, molecule-based targeted therapy has achieved remarkable success in clinical, and opened up a new era particulraly in the field of cancer therapy. Monoclonal antibodies and small molecule inhibitors are two pillars of this field. Additionally, a single-strand nucleic acid molecule called “chemical antibody” has also attracted increasing ...
Ting Zheng, Ziyue Ma, Quan Du
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PLoS ONE, 2022 BackgroundGrowth Hormone Releasing Hormone (GHRH), 44 amino acids containing hypothalamic hormone, retains the biological activity by its first 29 amino acids.
Burcu Ayhan-Sahin +4 more
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A grafting strategy for the design of improved G-quadruplex aptamers and high-activity DNAzymes. [PDF]
PLoS ONE, 2009 Nucleic acid aptamers are generally obtained by in vitro selection. Some have G-rich consensus sequences with ability to fold into the four-stranded structures known as G-quadruplexes.
Tao Li, Erkang Wang, Shaojun Dong
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Advances in Screening and Development of Therapeutic Aptamers Against Cancer Cells
Frontiers in Cell and Developmental Biology, 2021 Cancer has become the leading cause of death in recent years. As great advances in medical treatment, emerging therapies of various cancers have been developed.
Zheng Li +6 more
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