Results 91 to 100 of about 19,186 (244)

Large Phenotypic Enhancement of Structured Random RNA Pools. [PDF]

, 2020
Laboratory evolution of functional RNAs has applications in many areas of chemical and synthetic biology. In vitro selections critically depend on the presence of functional molecules, such as aptamers and ribozymes, in the starting sequence pools.
Chizzolini, Fabio, Dingilian, Armine I, Lupták, Andrej, Oumais, Mona, Passalacqua, Luiz FM, Szostak, Jack W   +5 more
core  

Aptamers as theranostic agents: modifications, serum stability and functionalisation [PDF]

, 2013
Aptamers, and the selection process known as Systematic Evolution of Ligands by Exponential Enrichment (SELEX) used to generate them, were first described more than twenty years ago.
Adler, Bagalkot, Bagalkot, Bentolila, Bunka, Campbell, Cerchia, Chelliserrykattil, Cheng, ChunGuang Li, Crouzier, Damha, Davies, Dean, Djordjevic, Doessing, Doessing, Dongxi Xiang, Ellington, Gao, Gold, Hadi Al.Shamaileh, Hofacker, Hou, Imaizumi, Joanna Macdonald, Kang, Kasahara, Kasahara, Kasahara, Kato, Kaur, Keefe, Koshkin, Kusser, Kuwahara, Kuwahara, Lee, Lee, Levy, Liang Qiao, Lingxue Kong, Mallikaratchy, Mallikaratchy, McNamara, Mi, Michael O'Connor, Michalet, Ming Wei, Mohan, Obika, Padilla, Padilla, Pasternak, Paterson, Pendergrast, Petersen, Peyman, Pinheiro, Robertson, Saenger, Samani, Santanu Bhattacharya, Sarah Shigdar, Sato, Schmidt, Sefah, Shangguan, Shangguan, Shi, Shigdar, Shigdar, Shigdar, Shoji, Shu-Feng Zhou, Song, Sorensen, Stephenson, Tao Wang, Texier, Tuerk, Vaught, Veedu, Wang, Wei Duan, White, Wilson, Yimin Zhu, Zhang   +88 more
core   +3 more sources

Polyphenol‐Based Biomaterials Against Cancer Radio/Chemotherapy‐Induced Intestinal Toxicity

Advanced NanoBiomed Research, EarlyView.
Radiotherapy/chemotherapy often causes intestinal toxicity, impairing cancer patients’ quality of life and treatment efficacy. Polyphenols protect against this injury via multiple mechanisms, but face oral use limitations. This review outlines their protective mechanisms and delivery challenges, highlighting recent oral delivery advances and future ...
Jixu Lu, Jing Chen, Ji Zhu, Lixin Ru, Dongxiao Zhang   +4 more
wiley   +1 more source

Novel Cell type-specific aptamer-siRNA delivery system for HIV-1 therapy [PDF]

, 2007
The successful use of small interfering RNAs (siRNAs) for therapeutic purposes requires safe and efficient delivery to specific cells and tissues. Here we demonstrate cell type-specific delivery of anti-HIV siRNAs via fusion to an anti-gp120 aptamer. The
Haitang Li, Jiehua Zhou, John Rossi, John Zaia, Shirley Li   +4 more
core   +2 more sources

Facile conversion of RNA aptamers to modular fluorescent sensors with tunable detection wavelengths. [PDF]

, 2011
A GTP aptamer was converted to a modular fluorescent GTP sensor by conjugation of RRE (Rev responsive element) RNA and successive complex formation with a fluorophore-modified Rev peptide.
Morii, Takashi, Nakano, Shun, Nakata, Eiji   +2 more
core   +1 more source

Aptamers in oncology: a diagnostic perspective [PDF]

, 2008
Nucleic acid sequences can produce a wide variety of three-dimensional conformations. Some of these structural forms are able to interact with proteins and small molecules with high affinity and specificity.
Khan, Huma, Missailidis, Sotiris
core  

The prebiotic evolutionary advantage of transferring genetic information from RNA to DNA. [PDF]

, 2011
In the early 'RNA world' stage of life, RNA stored genetic information and catalyzed chemical reactions. However, the RNA world eventually gave rise to the DNA-RNA-protein world, and this transition included the 'genetic takeover' of information storage ...
Chen, Irene A, Gerland, Ulrich, Leu, Kevin, Obermayer, Benedikt, Rajamani, Sudha   +4 more
core   +4 more sources

Evolving methods for rational de novo design of functional RNA molecules

, 2019
Artificial RNA molecules with novel functionality have many applications in synthetic biology, pharmacy and white biotechnology. The de novo design of such devices using computational methods and prediction tools is a resource-efficient alternative to ...
Findeiß, Sven, Günzel, Christian, Hammer, Stefan, Mörl, Mario   +3 more
core   +1 more source

Design principles for riboswitch function [PDF]

, 2009
Scientific and technological advances that enable the tuning of integrated regulatory components to match network and system requirements are critical to reliably control the function of biological systems. RNA provides a promising building block for the
A Belle, A Levchenko, A Zaslaver, Adam P. Arkin, B Suess, B Suess, CA Voigt, Chase L. Beisel, Christina D. Smolke, CI An, CL Beisel, DH Mathews, DJ Klein, DM Crothers, DW Selinger, E Dekel, FJ Isaacs, FJ Isaacs, GJ Leclerc, GM Emilsson, GM Suel, GR Zimmermann, HM Al-Hashimi, J Tomsic, JA Bernstein, JA Collins, JE Barrick, JF Lemay, JK Wickiser, JK Wickiser, K Lang, LJ Su, LV Danilova, M Acar, M Parisien, MN Win, MN Win, MR Bennett, MT Cheah, MT Woodside, N Hao, O Kensch, P Corish, PP Zarrinkar, PT Li, R Narsai, R Rieder, RD Jenison, RR Breaker, S Topp, S Topp, SA Lynch, SE Osborne, SK Desai, T Pan, TH Lee, TS Bayer, WC Winkler, WC Winkler, WJ Greenleaf, X Zhang, X Zhuang, Y Yokobayashi   +62 more
core   +4 more sources

Identification of Amino Acids and Nucleotides Required for Interaction Between BAFF‐R and its RNA Aptamer

The FASEB Journal, 2015
Current cancer therapies such as surgery, radiation, and chemotherapy can leave residual tumor cells and have off‐target effects. Aptamers are used in a type of targeted cancer therapy that more precisely identify and attack cancer cells, while leaving unaffected cells unharmed. In B‐cell malignancies, such as non‐Hodgkins lymphoma,
Monica Lares, John Rossi
openaire   +1 more source