Results 121 to 130 of about 581,942 (266)

Distance‐Dependent Energy Transfer Between Organic Fluorophores and Single‐Walled Carbon Nanotubes

Angewandte Chemie International Edition, EarlyView.
We demonstrate that the dsDNA part adopts a perpendicular orientation to the SWCNT and present a distance‐dependent energy transfer of single fluorescent dyes to SWCNTs. Carbon nanotube energy transfer (CNET) obeys a d−5 distance dependence with a characteristic distance of 7.4 nm (± 0.7 nm) for 50 % energy transfer.
Izabela Kamińska, Justus T. Metternich, Alan M. Szalai, Carolin Smidoda, Sayantani Chakraborty, Lela Vukovic, Sebastian Kruss, Philip Tinnefeld   +7 more
wiley   +1 more source

Packaging signals in single-stranded RNA viruses: nature’s alternative to a purely electrostatic assembly mechanism [PDF]

, 2013
The formation of a protective protein container is an essential step in the life-cycle of most viruses. In the case of single-stranded (ss)RNA viruses, this step occurs in parallel with genome packaging in a co-assembly process.
Bakker, S.E., Barker, A.M., Borodavka, A., Dykeman, Eric, Ford, R.J., Pearson, A.R., Phillips, S.E.V., Ranson, N.A., Stockley, P.G., Tuma, R., Twarock, R.   +10 more
core   +2 more sources

Phase Separation of Nucleic Acids: Mechanisms, Properties, and Applications

Angewandte Chemie International Edition, EarlyView.
Recent discoveries have shown that single‐stranded long‐chain nucleic acids can undergo temperature‐induced phase separation, enabling formation of micrometer‐sized condensates. This Minireview discusses the current mechanistic understanding of this phenomenon, highlights strategies for controlling the physical and chemical properties of these ...
Weixiang Chen, Johann Fritzen, Andreas Walther   +2 more
wiley   +1 more source

Energy-based method for designing aptamers to target phosphatidylcholine

Medicine in Drug Discovery
Diverse technologies are used to design nucleic acid aptamers to achieve targeted therapeutics, engineer diagnostic tools to detect specific biomolecules associated with disease-oriented signaling pathways, and develop drug delivery systems.
Fatima Alharbi, Hamed Alsulami, Suliman AlOmar, Md. Ashrafuzzaman   +3 more
doaj   +1 more source

The tyranny of adenosine recognition among RNA aptamers to coenzyme A

BMC Evolutionary Biology, 2003
Background Understanding the diversity of interactions between RNA aptamers and nucleotide cofactors promises both to facilitate the design of new RNA enzymes that utilize these cofactors and to constrain models of RNA World evolution.
Frank Joseph, Saran Dayal, Burke Donald H   +2 more
doaj   +1 more source

Nanoclay‐Engineered Scaffolds for the Controlled Delivery of Biomolecules in Regenerative Medicine

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT Regenerative medicine combines biomaterials, cells, scaffolds, and bioactive agents via modern technologies to aid in the reconstruction and repair of damaged tissues. Among these, nanoclay scaffolds have demonstrated unique advantages in facilitating the delivery of therapeutic agents.
Mehri Shadi, Saeed Vafaei‐Nezhad, Ahmad Gholamalizadeh Ahangar   +2 more
wiley   +1 more source

Evolving methods for rational de novo design of functional RNA molecules

, 2019
Artificial RNA molecules with novel functionality have many applications in synthetic biology, pharmacy and white biotechnology. The de novo design of such devices using computational methods and prediction tools is a resource-efficient alternative to ...
Findeiß, Sven, Günzel, Christian, Hammer, Stefan, Mörl, Mario   +3 more
core   +1 more source

Fluorophore ligand binding and complex stabilization of the RNA Mango and RNA Spinach aptamers

RNA: A publication of the RNA Society, 2016
The effective tracking and purification of biological RNAs and RNA protein complexes is currently challenging. One promising strategy to simultaneously address both of these problems is to develop high-affinity RNA aptamers against taggable small ...
Sunny C. Y. Jeng, H. Chan, E. Booy, S. McKenna, P. Unrau   +4 more
semanticscholar   +1 more source

Plasma Proteomics Identifies TAOK3 as a Potential Biomarker of Rheumatoid Arthritis Activity and a Novel Therapeutic Target

Arthritis &Rheumatology, Accepted Article.
Objective Bone destruction associated with active rheumatoid arthritis (RA) remains a major therapeutic challenge, with a lack of reliable molecular markers reflecting bone injury. This study aims to identify novel biomarkers linked to bone destruction in active RA through proteomic analysis, providing new strategies for precise monitoring and targeted
Pengfei Xin, Wenzhen Li, Xinyu A, Jun Shen, Xiaohui Meng, Yanqin Bian, Haihui Han, Zheng Xiang, Lei Ran, Songtao Sun, Jun Xie, Tao Yue, Qi Zhu, Xiaoming Zhang, Lu Xie, Lianbo Xiao   +15 more
wiley   +1 more source

Synthesis and Enzymatic Incorporation of Modified Deoxyuridine Triphosphates

Molecules, 2015
To expand the chemical functionality of DNAzymes and aptamers, several new modified deoxyuridine triphosphates have been synthesized. An important precursor that enables this aim is 5-aminomethyl dUTP, whereby the pendent amine serves as a handle for ...
Erkai Liu, Curtis H. Lam, David M. Perrin   +2 more
doaj   +1 more source