Results 21 to 30 of about 29,754 (236)
Chemistry & Biology, 2002 A controllable, intracellular RNA aptamer could be an invaluable therapeutic or discovery reagent. A report published in this journal shows that aptamer behavior can be regulated by a small molecule, paving the way for the development of more sophisticated ligand-regulated aptamers.
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Pharmaceutics, 2021 Nucleic acid aptamers have attracted considerable attention as next-generation pharmaceutical agents and delivery vehicles for small molecule drugs and therapeutic oligonucleotides.
Hiro Uemachi +5 more
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Molecular Therapy: Nucleic Acids, 2023 Here, we present DNA aptamers capable of specific binding to glial tumor cells in vitro, ex vivo, and in vivo for visualization diagnostics of central nervous system tumors.
Anna S. Kichkailo +54 more
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, 2018 Aptamers are in vitro selected oligonucleotides capable of specific, high-affinity binding to a wide variety of target molecules. These features enable their application in diagnostics, therapeutics, targeted delivery, fluorescence imaging, and biosensing.
Andrew Brian Kinghorn (Ed.) +2 more
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Methods for Improving Aptamer Binding Affinity
Molecules, 2016 Aptamers are single stranded oligonucleotides that bind a wide range of biological targets. Although aptamers can be isolated from pools of random sequence oligonucleotides using affinity-based selection, aptamers with high affinities are not always ...
Hijiri Hasegawa +3 more
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Aptamers: A Feasible Technology in Cancer Immunotherapy
Journal of Immunology Research, 2016 Aptamers are single-chained RNA or DNA oligonucleotides (ODNs) with three-dimensional folding structures which allow them to bind to their targets with high specificity.
M. M. Soldevilla +2 more
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Pharmaceuticals, 2012 The use of nucleic acid derived aptamers has rapidly expanded since the introduction of SELEX in 1990. Nucleic acid aptamers have demonstrated their ability to target a broad range of molecules in ways that rival antibodies, but advances have been very ...
Ralf Landgraf, Qian Zhang
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DNA Aptamers against Taiwan Banded Krait α-Bungarotoxin Recognize Taiwan Cobra Cardiotoxins
Toxins, 2016 Bungarus multicinctus α-bungarotoxin (α-Bgt) and Naja atra cardiotoxins (CTXs) share a common structural scaffold, and their tertiary structures adopt three-fingered loop motifs. Four DNA aptamers against α-Bgt have been reported previously.
Ying-Jung Chen +3 more
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Acta Biomedica Scientifica, 2022 Background. Aptamers are small single-stranded DNA or RNA molecules that have an affinity for a specific target molecule. The main method of aptamers construction is the technology of systematic evolution of ligands with exponential enrichment (SELEX ...
I. S. Solovarov +4 more
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Biological Procedures OnlineExosomes are increasingly recognized as important mediators of intercellular communication in cancer biology. Exosomes can be derived from cancer cells as well as cellular components in tumor microenvironment.
Yating Wu +5 more
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