Results 31 to 40 of about 76,545 (327)
Chemistry & Biology, 2002 A controllable, intracellular RNA aptamer could be an invaluable therapeutic or discovery reagent. A report published in this journal shows that aptamer behavior can be regulated by a small molecule, paving the way for the development of more sophisticated ligand-regulated aptamers.
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Pharmaceutics, 2021 Nucleic acid aptamers have attracted considerable attention as next-generation pharmaceutical agents and delivery vehicles for small molecule drugs and therapeutic oligonucleotides.
Hiro Uemachi +5 more
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Molecular Therapy: Nucleic Acids, 2023 Here, we present DNA aptamers capable of specific binding to glial tumor cells in vitro, ex vivo, and in vivo for visualization diagnostics of central nervous system tumors.
Anna S. Kichkailo +54 more
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, 2018 Aptamers are in vitro selected oligonucleotides capable of specific, high-affinity binding to a wide variety of target molecules. These features enable their application in diagnostics, therapeutics, targeted delivery, fluorescence imaging, and biosensing.
Andrew Brian Kinghorn (Ed.) +2 more
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Methods for Improving Aptamer Binding Affinity
Molecules, 2016 Aptamers are single stranded oligonucleotides that bind a wide range of biological targets. Although aptamers can be isolated from pools of random sequence oligonucleotides using affinity-based selection, aptamers with high affinities are not always ...
Hijiri Hasegawa +3 more
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Aptamers: A Feasible Technology in Cancer Immunotherapy
Journal of Immunology Research, 2016 Aptamers are single-chained RNA or DNA oligonucleotides (ODNs) with three-dimensional folding structures which allow them to bind to their targets with high specificity.
M. M. Soldevilla +2 more
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Model-guided design of ligand-regulated RNAi for programmable control of gene expression [PDF]
, 2008 Progress in constructing biological networks will rely on the development of more advanced components that can be predictably modified to yield optimal system performance.
Chase L Beisel +4 more
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Engineering ligand-responsive RNA controllers in yeast through the assembly of RNase III tuning modules [PDF]
, 2011 The programming of cellular networks to achieve new biological functions depends on the development of genetic tools that link the presence of a molecular signal to gene-regulatory activity.
An +37 more
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A blue light receptor that mediates RNA binding and translational regulation [PDF]
, 2019 Sensory photoreceptor proteins underpin light-dependent adaptations in nature and enable the optogenetic control of organismal behavior and physiology.
Bittl, Robert +9 more
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Pharmaceuticals, 2012 The use of nucleic acid derived aptamers has rapidly expanded since the introduction of SELEX in 1990. Nucleic acid aptamers have demonstrated their ability to target a broad range of molecules in ways that rival antibodies, but advances have been very ...
Ralf Landgraf, Qian Zhang
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