Results 131 to 140 of about 43,591 (296)

With Regard to the Expression Status of Sarcolemmal Aquaporin 4 in Human Muscular Dystrophies

Neurology and Clinical Neuroscience, EarlyView.
ABSTRACT Human muscular dystrophies are inherited muscle‐wasting diseases caused by the various kinds of gene mutations. Among them, Duchenne muscular dystrophy (DMD) is a representative type. Before the discovery of the causative dystrophin gene of DMD, the fragile myofiber plasma membrane was thought to be the trigger of myofiber necrosis in DMD ...
Yoshihiro Wakayama, Takahiro Jimi
wiley   +1 more source

Comprehensive DIA‐MS Proteomics of Root Basal Nodes Elucidates Mechanisms of Salt Tolerance in Rice

PROTEOMICS, EarlyView.
ABSTRACT Soil salinity severely affects rice growth, yield, and quality, posing a global food security challenge. Rice is particularly vulnerable to high salinity, which restricts growth and tolerance to other stresses. To address this, breeding efforts have been made in the past, leading to the generation of multi‐stress‐tolerant rice lines.
Cheol Woo Min, Choonseok Lee, Ravi Gupta, Gi Hyun Lee, Ji Soo Kim, Na Won Park, Joong Hyoun Chin, Ki‐Hong Jung, Sun Tae Kim   +8 more
wiley   +1 more source

Aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders: progress of experimental models based on disease pathogenesis

Neural Regeneration Research
Neuromyelitis optica spectrum disorders are neuroinflammatory demyelinating disorders that lead to permanent visual loss and motor dysfunction. To date, no effective treatment exists as the exact causative mechanism remains unknown.
Li Xu, Huiming Xu, Changyong Tang
doaj   +1 more source

Evidence for direct and sleep-moderated relationships between aquaporin-4 genetic variants and Alzheimer's disease phenotypes. [PDF]

Alzheimers Dement
Abstract INTRODUCTION Variants in the aquaporin‐4 gene (AQP4) have been associated with Alzheimer's disease (AD) diagnosis, cognition, and brain amyloid beta (Aβ) and may affect the sleep and Aβ relationship. Their association with other AD‐related phenotypes/disease progression remain largely unknown.
Porter T, Armstrong AM, O'Brien EK, Doré V, Bourgeat P, Turner M, Maruff P, Rowe CC, Brown BM, Villemagne VL, Rainey-Smith SR, Laws SM, AIBL Research Group.   +12 more
europepmc   +2 more sources

Current Cell/Organoid and Animal Models for Primary Sclerosing Cholangitis

Portal Hypertension &Cirrhosis, EarlyView.
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease with limited therapeutic options and a marked risk of progression to biliary fibrosis, cirrhosis, and malignancy. Progress in PSC research has been hindered by the lack of models that faithfully recapitulate the complex biliary microenvironment and disease heterogeneity ...
Qigu Yao, Sheng Cheng, Qiaoling Pan, Jiong Yu, Hongcui Cao   +4 more
wiley   +1 more source

The Role of Polyphenols in Respiratory and Gut Health: From the Perspective of Gut‐Lung Axis

Phytotherapy Research, EarlyView.
ABSTRACT The gut‐lung axis constitutes a dynamic, multidirectional communication platform between the gastrointestinal and respiratory tracts. Its complexity arises from the integrated crosstalk among the microbiota, immune system, and redox homeostasis, collectively influencing disease susceptibility and progression.
Jian Kang, YongJun Du, Yanmei Hou, Liangliang Hao, Zhen Chen, Haoyang Xie, Chuantao Zhang, Lei Li   +7 more
wiley   +1 more source

Opportunistic infections of the retina in patients with aquaporin-4 antibody disease.

, 2014
IMPORTANCE: Patients with neuromyelitis optica who have aquaporin-4 antibodies are being identified and receiving immunosuppressant treatment earlier and more aggressively as a result of increasing awareness of the importance of preventing relapses ...
Jones, N, Patel, CK, Yusuf, IH, Palace, JA, Matthews, BN, Donati, M, George, JS, Hillier, C, Elston, JS, Kitley, JL, Cortes, N, Leite, MI, Calladine, D, Munneke, R   +13 more
core   +1 more source

Comparative Analysis of Stress Adaptation in the Yeast Microbiome of Cactus

Yeast, EarlyView.
Yeasts and related fungi isolated from cacti or nearby non‐cactus plants were characterized phenotypically and genomically, revealing differences that hint at modes of adaptation to the cactus host. ABSTRACT Together with other fungi, yeasts make up a significant component of the plant microbiome. As the planet warms, cacti expand their range.
Alya N. Hussain, Kevin T. Fotso, Michael A. McMurray   +2 more
wiley   +1 more source

Deciphering unusually large modulations in two related organic hydroxy channel structures

Acta Crystallographica Section B, EarlyView.
Two related organic hydroxy‐channel compounds are shown to have unusually large structural modulations.The incommensurately modulated structures of two related organic hydroxy‐channel compounds [(R)‐1‐(1,3‐dihydroxypropan‐2‐yl)‐3‐(octan‐2‐yl)urea, 1; 1‐(1,3‐dihydroxypropan‐2‐yl)‐3‐octylurea, 2] have been determined and compared to the structure of a ...
Arie van der Lee, Ioan Stroia, Li-Bo Huang, Erol Licsandru, Istvan Kocsis, Mihail Deleanu, Christian Hübschle, Mihail Barboiu, Olivier Pérez   +8 more
wiley   +1 more source

Visual discrimination impairment after experimental stroke is associated with disturbances in the polarization of the astrocytic aquaporin-4 and increased accumulation of neurotoxic proteins

, 2019
Numerous clinical studies have documented the high incidence of cognitive impairment after stroke. However, there is only limited knowledge about the underlying mechanisms.
Ong, Lin Kooi, Walker, Frederick R., Sanchez-Bezanilla, Sonia, TeBay, Clifford, Nilsson, Michael   +4 more
core   +1 more source