Results 11 to 20 of about 69,061 (289)
Aquaporin-4 and brain edema. [PDF]
Pediatric Nephrology, 2007 Aquaporin-4 (AQP4) is a water-channel protein expressed strongly in the brain, predominantly in astrocyte foot processes at the borders between the brain parenchyma and major fluid compartments, including cerebrospinal fluid (CSF) and blood.
A Lehmenkuhler +38 more
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Neuromyelitis optica pathogenesis and aquaporin 4 [PDF]
Journal of Neuroinflammation, 2008 Neuromyelitis optica (NMO) is a severe, debilitating human disease that predominantly features immunopathology in the optic nerves and the spinal cord.
Kerr Douglas +3 more
doaj +3 more sources
Skull diploë is rich in aquaporin-4 [PDF]
Heliyon, 2020 Aquaporin-4 (AQP4) is a water conducting membrane integral protein channel which is widely expressed in the astrocyte system of the brain. During the development of the AQP4 positron emission tomography (PET) imaging agent [11C]TGN-020 (N-(1,3,4 ...
Yuji Suzuki +7 more
doaj +3 more sources
Accumulation of Astrocytic Aquaporin 4 and Aquaporin 1 in Prion Protein Plaques [PDF]
Journal of Neuropathology & Experimental Neurology, 2020 Abstract Gerstmann-Sträussler-Scheinker (GSS) disease with P102L mutation and familial Creutzfeldt-Jakob disease (CJD) with V180I mutation are 2 major hereditary prion diseases in Japan. GSS and some familial CJD [V180I] exhibit characteristic prion protein (PrP) plaques. Overexpression of the astrocytic water channel proteins aquaporin (
Shoko Sadashima +7 more
openalex +3 more sources
Aquaporin-4 autoimmunity [PDF]
Neurology Neuroimmunology & Neuroinflammation, 2015 Neuromyelitis optica (NMO) and a related spectrum of inflammatory CNS disorders are unified by detection of a serum autoantibody specific for the aquaporin-4 (AQP4) water channel, which is abundant in astrocytic foot processes. The classic clinical manifestations of NMO are optic neuritis and longitudinally extensive transverse myelitis.
Zekeridou, Anastasia, Lennon, Vanda A.
openaire +2 more sources
Evaluation of aquaporin‐4 antibody assays [PDF]
Clinical and Experimental Neuroimmunology, 2014 AbstractAquaporin‐4 (AQP4) is a water channel protein that is most highly, but not exclusively, expressed in the central nervous system. In 2005 AQP4 was shown to be the antigenic target of neuromyelitis optica‐immunoglobulin G (NMO‐IgG, or AQP4‐IgG), an antibody found specifically in patients with NMO and in formes frustes of NMO, such as ...
Patrick Waters +5 more
openalex +4 more sources
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2013 Review on AQP4 (aquaporin 4), with data on DNA, on the protein encoded, and where the gene is implicated.
RIBATTI, Domenico, NICO, Beatrice
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Aquaporin-4 and Cognitive Disorders
Aging and disease, 2022 Aquaporin-4 (AQP4) is the most abundantly expressed aquaporin in the central nervous system (CNS) and is an integral part of the glymphatic system that cannot be ignored. The CNS has the glymphatic system instead of the conventional lymphatic system.
Wang, Yifan +3 more
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European Radiology Experimental, 2021 Background Aquaporin-4 is a membrane channel protein that is highly expressed in brain astrocytes and facilitates the transport of water molecules. It has been suggested that suppression of aquaporin-4 function may be an effective treatment for reducing ...
Takuya Urushihata +9 more
doaj +1 more source
Aquaporin-4 and Cerebrovascular Diseases [PDF]
International Journal of Molecular Sciences, 2016 Cerebrovascular diseases are conditions caused by problems with brain vasculature, which have a high morbidity and mortality. Aquaporin-4 (AQP4) is the most abundant water channel in the brain and crucial for the formation and resolution of brain edema.
Chu, Heling +7 more
openaire +2 more sources