Results 11 to 20 of about 11,586,786 (268)

Aquaporin-4 and Cognitive Disorders

Aging and disease, 2022
Aquaporin-4 (AQP4) is the most abundantly expressed aquaporin in the central nervous system (CNS) and is an integral part of the glymphatic system that cannot be ignored. The CNS has the glymphatic system instead of the conventional lymphatic system. The
Yifan Wang, Chuyi Huang, Q. Guo, H. Chu
semanticscholar   +3 more sources

Aquaporin-4 and brain edema. [PDF]

Pediatric Nephrology, 2007
Aquaporin-4 (AQP4) is a water-channel protein expressed strongly in the brain, predominantly in astrocyte foot processes at the borders between the brain parenchyma and major fluid compartments, including cerebrospinal fluid (CSF) and blood.
A Lehmenkuhler, Alan S. Verkman, AS Verkman, AS Verkman, D Wenzel, DK Binder, DK Binder, DK Binder, DS Prough, GT Manley, H Wen, HJ Reulen, HK Kimelberg, I Klatzo, I Roberts, J Badaut, J Hu, J Li, J Li, JE Rash, JE Rash, K Oshio, KI Auguste, M Amiry-Moghaddam, M Amiry-Moghaddam, M Elkjaer, Marios C. Papadopoulos, MC Papadopoulos, MC Papadopoulos, MC Papadopoulos, NR Saunders, O Bloch, P Agre, P Padmawar, PM Rodier, S Nielsen, S Saadoun, S Saadoun, T Ma   +38 more
core   +5 more sources

Induction of aquaporin 4-reactive antibodies in Lewis rats immunized with aquaporin 4 mimotopes [PDF]

Acta Neuropathologica Communications, 2020
Most cases of neuromyelitis optica spectrum disorders (NMOSD) harbor pathogenic autoantibodies against the water channel aquaporin 4 (AQP4). Binding of these antibodies to AQP4 on astrocytes initiates damage to these cells, which culminates in the ...
Irina Tsymala, Magdalini Nigritinou, Bleranda Zeka, Rouven Schulz, Felix Niederschick, Mia Matković, Isabel J. Bauer, Michael Szalay, Kathrin Schanda, Magdalena Lerch, Tatsuro Misu, Kazuo Fujihara, Jeffrey L. Bennett, Charlotte Dahle, Florence Pache, Paulus Rommer, Fritz Leutmezer, Zsolt Illes, Maria Isabel Leite, Jacqueline Palace, Petra Scholze, Markus Reindl, Hans Lassmann, Monika Bradl   +23 more
doaj   +6 more sources

Neuromyelitis optica pathogenesis and aquaporin 4 [PDF]

Journal of Neuroinflammation, 2008
Neuromyelitis optica (NMO) is a severe, debilitating human disease that predominantly features immunopathology in the optic nerves and the spinal cord.
Kerr Douglas, Levy Michael, Graber David J, Wade William F   +3 more
doaj   +4 more sources

Skull diploë is rich in aquaporin-4 [PDF]

Heliyon, 2020
Aquaporin-4 (AQP4) is a water conducting membrane integral protein channel which is widely expressed in the astrocyte system of the brain. During the development of the AQP4 positron emission tomography (PET) imaging agent [11C]TGN-020 (N-(1,3,4 ...
Yuji Suzuki, Hiroki Kitaura, Yukimi Nakamura, Akiyoshi Kakita, Vincent J. Huber, Nicholas Capozzoli, Ingrid L. Kwee, Tsutomu Nakada   +7 more
doaj   +4 more sources

Aquaporin 4: a player in cerebral edema and neuroinflammation [PDF]

Journal of Neuroinflammation, 2012
Neuroinflammation is a common pathological event observed in many different brain diseases, frequently associated with blood brain barrier (BBB) dysfunction and followed by cerebral edema.
Fukuda Andrew M, Badaut Jerome
doaj   +4 more sources

Aquaporin-3 and aquaporin-4 are sorted differently and separately in the trans-Golgi network. [PDF]

PLoS ONE, 2013
Aquaporin-3 (AQP3) and aquaporin-4 (AQP4) are homologous proteins expressed in the basolateral plasma membrane of kidney collecting duct principal cells, where they mediate the exit pathway for apically reabsorbed water.
Eva C Arnspang, Sabrina Sundbye, W James Nelson, Lene N Nejsum   +3 more
doaj   +6 more sources

Antibody to aquaporin 4 in the diagnosis of neuromyelitis optica. [PDF]

PLoS Medicine, 2007
BackgroundNeuromyelitis optica (NMO) is a demyelinating disease of the central nervous system (CNS) of putative autoimmune aetiology. Early discrimination between multiple sclerosis (MS) and NMO is important, as optimum treatment for both diseases may ...
Friedemann Paul, Sven Jarius, Orhan Aktas, Martin Bluthner, Oliver Bauer, Heribert Appelhans, Diego Franciotta, Roberto Bergamaschi, Edward Littleton, Jacqueline Palace, Hans-Peter Seelig, Reinhard Hohlfeld, Angela Vincent, Frauke Zipp   +13 more
doaj   +5 more sources

Aquaporin-4 antibody dynamics and relapse risk in seropositive neuromyelitis optica spectrum disorder treated with immunosuppressants

Journal of Neurological Sciences, 2023
To investigate aquaporin‐4 antibody (AQP4‐IgG) dynamics and relapse risk in patients with seropositive neuromyelitis optica spectrum disorder treated with immunosuppressants.
H. Yin, Ying-jie Wang, Mange Liu, Dingding Zhang, H. Ren, Zhi-Feng Mao, Yao Zhang, B. Peng, L. Cui, Yan Xu   +9 more
semanticscholar   +1 more source

Alterations in Aquaporin-4-IgG Serostatus in 986 Patients: A Laboratory-Based Longitudinal Analysis

Annals of Neurology, 2023
This study was undertaken to investigate factors associated with aquaporin‐4 (AQP4)‐IgG serostatus change using a large serological database.
M. Majed, Cristina Valencia Sanchez, J. Bennett, J. Fryer, Martin D Mulligan, Vyankya Redenbaugh, A. McKeon, J. Mills, D. Wingerchuk, V. Lennon, B. Weinshenker, John Chen, E. Flanagan, S. Pittock, Amy C. Kunchok   +14 more
semanticscholar   +1 more source