Results 41 to 50 of about 11,586,786 (268)

Long-term efficacy and safety of inebilizumab in neuromyelitis optica spectrum disorder: Analysis of aquaporin-4–immunoglobulin G–seropositive participants taking inebilizumab for ⩾4 years in the N-MOmentum trial

Multiple Sclerosis, 2021
Background: Efficacy and safety of inebilizumab for treatment of neuromyelitis optica spectrum disorder in adults seropositive for aquaporin-4 (AQP4)–immunoglobulin (Ig) G were demonstrated in the 28-week randomized controlled period of the N-MOmentum ...
M. Rensel, A. Zabeti, M. Mealy, D. Cimbora, D. She, J. Drappa, E. Katz   +6 more
semanticscholar   +1 more source

Frequency of New Silent MRI Lesions in Myelin Oligodendrocyte Glycoprotein Antibody Disease and Aquaporin-4 Antibody Neuromyelitis Optica Spectrum Disorder

JAMA Network Open, 2021
Key Points Question How common is silent T2 lesion activity in myelin oligodendrocyte glycoprotein antibody disease (MOGAD) and aquaporin-4 antibody neuromyelitis optica spectrum disorder (AQP4-NMOSD)?
V. Camera, Leah Holm-Mercer, Ali Asgar Hatim Ali, S. Messina, Timotej Horvat, W. Kuker, M. Leite, Jacqueline A Palace   +7 more
semanticscholar   +1 more source

Cerebrospinal fluid aquaporin-4-immunoglobulin G disrupts blood brain barrier [PDF]

, 2015
To clarify the significance of immunoglobulin G autoantibody specific for the astrocyte water channel aquaporin-4 in cerebrospinal fluid, aquaporin-4-immunoglobulin G from a neuromyelitis optica patient was administered intrathecally to naïve mice, and ...
Asgari, Nasrin, Berg, Carsten Tue, Khorooshi, Reza, Mørch, Marlene Thorsen, Owens, Trevor   +4 more
core   +2 more sources

Genetic deletion of laminin isoforms β2 and γ3 induces a reduction in Kir4.1 and aquaporin-4 expression and function in the retina. [PDF]

PLoS ONE, 2011
Glial cells such as retinal Müller glial cells are involved in potassium ion and water homeostasis of the neural tissue. In these cells, inwardly rectifying potassium (Kir) channels and aquaporin-4 water channels play an important role in the process of ...
Petra G Hirrlinger, Thomas Pannicke, Ulrike Winkler, Thomas Claudepierre, Shweta Varshney, Christine Schulze, Andreas Reichenbach, William J Brunken, Johannes Hirrlinger   +8 more
doaj   +1 more source

Fatal anti-aquaporin-4 seropositive neuromyelitis optica spectrum disorder in tuberculosis [PDF]

, 2014
© 2014 Sridhar et al.; licensee BioMed Central Ltd.Background: Neuromyelitis optica (NMO) is an autoimmune inflammatory condition of the central nervous system that is characterized by circulating anti-aquaporin-4 antibodies, transverse myelitis and ...
Chan, JFW, Sridhar, S, Yuen, KY
core   +1 more source

Barley plasma membrane intrinsic proteins (PIP aquaporins) as water and CO2 transporters [PDF]

, 2008
We identified barley aquaporins and demonstrated that one, HvPIP2;1, transports water and CO2. Regarding water homeostasis in plants, regulations of aquaporin expression were observed in many plants under several environmental stresses. Under salt stress,
C Zhu, DT Clarkson, DT Luu, E Zelazny, F Chaumont, GJ Cooper, GP Bienert, I Terashima, J Flexas, J Sakurai, J Takano, JF Ma, JY Jang, K Fetter, K Sato-Nara, LH Liu, M Katsuhara, M Katsuhara, M Katsuhara, M Katsuhara, Maki Katsuhara, N Uehlein, NL Nakhoul, P Kjellbom, R Aharon, R Vandeleur, S Suga, S Törnroth-Horsefield, SD Tyerman, TP Jahn, U Johanson, X Yang, YT Hanba, Yuko T. Hanba   +33 more
core   +1 more source

Aquaporin-4 gene silencing protects injured neurons after early cerebral infarction

Neural Regeneration Research, 2015
Aquaporin-4 regulates water molecule channels and is important in tissue regulation and water transportation in the brain. Upregulation of aquaporin-4 expression is closely related to cellular edema after early cerebral infarction.
Zhan-ping He, Hong Lu
doaj   +1 more source

Aquaporin 4 and its Relationship with Brain Astrocytomas – Literature Review

Brazilian Neurosurgery, 2023
Background Aquaporins (AQPs) are a family of membrane proteins that regulate the osmotic permeability of the plasma membrane. There are described in the literature a total of 13 types of Aquaporins in mammals, each with different places of expression. In
Raphael Vinícius Gonzaga Vieira, Rafaela Farias, Manuela Correa de Toledo Peres, Maria Clara Seba, Paulo Henrique Pires de Aguiar   +4 more
doaj   +1 more source

Expression and Localization of aquaporin‐1 in Temporomandibular Joint Disc with Internal Derangement [PDF]

, 2012
Background: Internal derangement is the most frequent arthropathy affecting the temporomandibular joint, where its commonest form is anterior disc displacement with or without reduction.
Almeida, Luis Eduardo, Caltabiano, Rosario, Carnazza, Maria Luisa, Galanti, Concetta, Leonardi, Rosalia, Loreto, Carla, Musumeci, Giuseppe, Pannone, Giuseppe   +7 more
core   +2 more sources

The Involvement of Aquaporin-4 in the Interstitial Fluid Drainage Impairment Following Subarachnoid Hemorrhage

Frontiers in Aging Neuroscience, 2021
The mechanism of brain injury following subarachnoid hemorrhage (SAH) has not yet been clarified. The glymphatic system (GS), a glia-dependent waste clearance pathway, drains away soluble waste proteins and metabolic products, even some toxic factors ...
E. Liu, Xianlong Peng, Haowen Ma, Yan Zhang, Xiaomei Yang, Yixuan Zhang, L. Sun, Junhao Yan   +7 more
semanticscholar   +1 more source