Arctiin protects against cardiac hypertrophy through inhibiting MAPKs and AKT signaling pathways
Journal of Pharmacological Sciences, 2017 Purpose: The mitogen-activated protein kinases (MAPKs) and protein kinase B (AKT) pathways have emerged as essential intracellular signaling pathways in eukaryotic cells, particularly as regulators of cardiac hypertrophy.
Jie Ren, Qi-Zhu Tang, Ning Zhang
exaly +4 more sources
High Cholesterol-Induced Bone Loss Is Attenuated by Arctiin via an Action in Osteoclasts [PDF]
Nutrients, 2022 High cholesterol-induced bone loss is highly associated with oxidative stress, which leads to the generation of oxysterols, such as 7-ketocholesterol (7-KC).
Hyun-Jung Park, Hye-Seon Choi
exaly +3 more sources
Molecules, 2023 The poor oral bioavailability of arctiin caused by its low water solubility is the biggest obstacle in developing it as a drug. In this work, a new water-soluble glucuronide derivative of arctiin (arctigenin-4′-O-glucuronide) was synthesized through 2,2 ...
Xia Xu +6 more
doaj +2 more sources
Anti-inflammatory function of arctiin by inhibiting COX-2 expression via NF-κB pathways [PDF]
Journal of Inflammation, 2011 Background Arctiin, isolated from Forsythia suspensa has been reported to have anti-inflammatory, anti-oxidant, antibacterial, and antiviral effects in vitro. However, there has been a lack of studies regarding its effects on immunological activity.
Lee Chong-Kil +10 more
doaj +2 more sources
Arctiin blocks hydrogen peroxide-induced senescence and cell death though microRNA expression changes in human dermal papilla cells [PDF]
Biological Research, 2014 BACKGROUND: Accumulating evidence indicates that reactive oxygen species (ROS) are an important etiological factor for the induction of dermal papilla cell senescence and hair loss, which is also known alopecia.
Seunghee Bae +10 more
doaj +2 more sources
Determination of Arctiin and Arctigenin Contents in Arctium Tomentosum Mill. by HPLC Method [PDF]
E-Journal of Chemistry, 2011 A simple, precise, rapid and accurate, binary-phase high performance liquid chromatographic method has been developed for the determination of arctiin and arctigenin contents in the Arctium tomentosumMill. with short run time.
Xiaoying Zhou +4 more
doaj +2 more sources
Journal of Traditional Chinese Medical Sciences, 2023 Objective: To screen active constituents of traditional Chinese medicines (TCMs) as potential virulence inhibitors of Salmonella pathogenicity island III (SPI-3).
Mengdi Cui +9 more
doaj +2 more sources
Unveiling the Antihyperglycemic Potential of Arctium lappa L. (Asteraceae): Traditional Application, Phytochemistry, and Molecular Insights [PDF]
FoodsDiabetes mellitus is a chronic disease requiring multifunctional natural agents. Arctium lappa is traditionally used in Eastern and European medicine to address metabolic disorders.
Amangul A. Uzbekova +7 more
doaj +2 more sources
Arctiin alleviates the progression of osteoarthritis by regulating the cholesterol metabolic pathway [PDF]
Scientific ReportsOsteoarthritis (OA) is a multi-factorial degenerative joint disease with unclear pathogenesis. Conservative treatments, primarily aimed at pain relief, fail to halt disease progression.
Jiale Mai +4 more
doaj +2 more sources
Extraction, quantification, formulation and evaluation of oral capsules from burdock fruits [PDF]
Research Journal of Pharmacognosy, 2017 Background and objectives: Burdock (Arcticum lappa L.) is a Eurasian species of plants in the sunflower family and has been used for hundreds of years by scientists and traditionally in North America, Europe, Asia and especially in China.
F. Arab +3 more
doaj +1 more source