Results 11 to 20 of about 8,104 (224)

Arenaviruses: Old viruses present new solutions for cancer therapy

Frontiers in Immunology, 2023
Viral-based cancer therapies have tremendous potential, especially in the context of treating poorly infiltrated cold tumors. However, in tumors with intact anti-viral interferon (IFN) pathways, while some oncolytic viruses induce strong innate and ...
Paweł Stachura, Paweł Stachura, Olivia Stencel, Zhe Lu, Arndt Borkhardt, Aleksandra A. Pandyra   +5 more
doaj   +2 more sources

Validation of Inactivation Methods for Arenaviruses

Viruses, 2021
Several of the human-pathogenic arenaviruses cause hemorrhagic fever and have to be handled under biosafety level 4 conditions, including Lassa virus. Rapid and safe inactivation of specimens containing these viruses is fundamental to enable downstream ...
Silke Olschewski, Anke Thielebein, Chris Hoffmann, Olivia Blake, Jonas Müller, Sabrina Bockholt, Elisa Pallasch, Julia Hinzmann, Stephanie Wurr, Neele Neddersen, Toni Rieger, Stephan Günther, Lisa Oestereich   +12 more
doaj   +2 more sources

Differential Immune Responses to Hemorrhagic Fever-Causing Arenaviruses

Vaccines, 2019
The family Arenaviridae contains several pathogens of major clinical importance. The Old World (OW) arenavirus Lassa virus is endemic in West Africa and is estimated to cause up to 300,000 infections each year.
Emily Mantlo, Slobodan Paessler, Cheng Huang   +2 more
doaj   +2 more sources

Highly Diverse Arenaviruses in Neotropical Bats, Brazil

Emerging Infectious Diseases, 2022
We detected arenavirus RNA in 1.6% of 1,047 bats in Brazil that were sampled during 2007–2011. We identified Tacaribe virus in 2 Artibeus sp. bats and a new arenavirus species in Carollia perspicillata bats that we named Tietê mammarenavirus.
Luiz Gustavo Bentim Góes, Carlo Fischer, Angélica Cristine Almeida Campos, Cristiano de Carvalho, Andrés Moreira-Soto, Guilherme Ambar, Adriana Ruckert da Rosa, Debora Cardoso de Oliveira, Wendy Karen Jo, Ariovaldo P. Cruz-Neto, Wagner André Pedro, Luzia Helena Queiroz, Paola Minoprio, Edison L. Durigon, Jan Felix Drexler   +14 more
doaj   +2 more sources

Antibodies to the Glycoprotein GP2 Subunit Cross-React between Old and New World Arenaviruses

mSphere, 2018
Arenaviruses pose a major public health threat and cause numerous infections in humans each year. Although most viruses belonging to this family do not cause disease in humans, some arenaviruses, such as Lassa virus and Machupo virus, are the etiological
Fatima Amanat, James Duehr, Lisa Oestereich, Kathryn M. Hastie, Erica Ollmann Saphire, Florian Krammer   +5 more
doaj   +2 more sources

Hemorrhagic Fever-Causing Arenaviruses: Lethal Pathogens and Potent Immune Suppressors

Frontiers in Immunology, 2019
Hemorrhagic fevers (HF) resulting from pathogenic arenaviral infections have traditionally been neglected as tropical diseases primarily affecting African and South American regions.
Morgan E. Brisse, Morgan E. Brisse, Hinh Ly   +2 more
doaj   +2 more sources

No measurable adverse effects of Lassa, Morogoro and Gairo arenaviruses on their rodent reservoir host in natural conditions

Parasites & Vectors, 2017
Background In order to optimize net transmission success, parasites are hypothesized to evolve towards causing minimal damage to their reservoir host while obtaining high shedding rates. For many parasite species however this paradigm has not been tested,
Joachim Mariën, Benny Borremans, Sophie Gryseels, Barré Soropogui, Luc De Bruyn, Gédéon Ngiala Bongo, Beate Becker-Ziaja, Joëlle Goüy de Bellocq, Stephan Günther, N’Faly Magassouba, Herwig Leirs, Elisabeth Fichet-Calvet   +11 more
doaj   +2 more sources

Animal Models of Pathogenic New World Arenaviruses

Microorganisms
Since the emergence of Junín virus in 1953, pathogenic New World arenaviruses have remained a public health concern. These viruses, which also include Machupo virus, Guanarito virus, Sabiá virus, and Chapare virus, cause acute viral hemorrhagic fever and
Alexander V. Alvarado, Robert W. Cross, Thomas W. Geisbert, Courtney Woolsey   +3 more
doaj   +2 more sources

Reporter-Expressing, Replicating-Competent Recombinant Arenaviruses

Viruses, 2016
Several arenaviruses cause hemorrhagic fever (HF) disease in humans and pose an important public health problem in their endemic regions. To date, no Food and Drug Administration (FDA)-licensed vaccines are available to combat human arenavirus infections,
Luis Martínez-Sobrido, Juan Carlos de la Torre   +1 more
doaj   +2 more sources

Human Hemorrhagic Fever Causing Arenaviruses: Molecular Mechanisms Contributing to Virus Virulence and Disease Pathogenesis

Pathogens, 2015
Arenaviruses include multiple human pathogens ranging from the low-risk lymphocytic choriomeningitis virus (LCMV) to highly virulent hemorrhagic fever (HF) causing viruses such as Lassa (LASV), Junin (JUNV), Machupo (MACV), Lujo (LUJV), Sabia (SABV ...
Junjie Shao, Yuying Liang, Hinh Ly
doaj   +2 more sources