Results 21 to 30 of about 8,104 (224)

Strategies of rational and structure-driven vaccine design for Arenaviruses. [PDF]

Infect Genet Evol
The COVID-19 outbreak has highlighted the importance of pandemic preparedness for the prevention of future health crises. One virus family with high pandemic potential are Arenaviruses, which have been detected almost worldwide, particularly in Africa ...
Peter AS, Hoffmann DS, Klier J, Lange CM, Moeller J, Most V, Wüst CK, Beining M, Gülesen S, Junker H, Brumme B, Schiffner T, Meiler J, Schoeder CT.   +13 more
europepmc   +2 more sources

The Estimation of Efficacy of Nonspecific Medications Against Hemorrhagic Fevers Caused by Arenaviruses

Антибиотики и Химиотерапия, 2023
The article presents an analysis of studies assessing the effectiveness of new nonspecific medications against hemorrhagic fevers caused by arenaviruses.
Т. Е. Sizikova, V. N. Lebedev, S. V. Borisevich   +2 more
doaj   +1 more source

Targeting the apical domain of the transferrin receptor: Development of a new protein scaffold for cellular delivery. [PDF]

Protein Sci
Abstract Human transferrin receptor 1 (TfR) is essential for cellular iron homeostasis by internalizing the iron carrier proteins transferrin and ferritin. It is also an entry point for various pathogens, such as South American hemorrhagic fever caused by arenaviruses and the malaria parasite Plasmodium vivax, which utilize TfR to gain access to cells.
Veetil AA, Sjöström DJ, Iribarren C, Mohlin C, Ambrosetti E, Bjelic S.   +5 more
europepmc   +2 more sources

Temporal changes in pathology and viral RNA distribution in guinea pigs following separate infection with two New World Arenaviruses

PLoS Neglected Tropical Diseases, 2023
Numerous arenaviruses have been identified throughout the Americas and a subset of these viruses cause viral hemorrhagic fever in humans. This study compared the pathology and viral RNA distribution in Hartley guinea pigs challenged with two human ...
C. Cline, Xiankun Zeng, Todd M Bell, Carl I. Shaia, P. Facemire, Janice A Williams, N. Davis, April M. Babka, E. Picado, Colin Fitzpatrick, J. W. Golden   +10 more
semanticscholar   +1 more source

Delayed low-dose oral administration of 4'-fluorouridine inhibits pathogenic arenaviruses in animal models of lethal disease. [PDF]

Sci Transl Med
Development of broad-spectrum antiviral therapies is critical for outbreak and pandemic preparedness against emerging and reemerging viruses. Viruses inducing hemorrhagic fevers cause high morbidity and mortality in humans and are associated with several
Welch SR, Spengler JR, Westover JB, Bailey KW, Davies KA, Aida-Ficken V, Bluemling GR, Boardman KM, Wasson SR, Mao S, Kuiper DL, Hager MW, Saindane MT, Andrews MK, Krueger RE, Sticher ZM, Jung KH, Chatterjee P, Shrivastava-Ranjan P, Lo MK, Coleman-McCray JD, Sorvillo TE, Genzer SC, Scholte FEM, Kelly JA, Jenks MH, McMullan LK, Albariño CG, Montgomery JM, Painter GR, Natchus MG, Kolykhalov AA, Gowen BB, Spiropoulou CF, Flint M.   +34 more
europepmc   +2 more sources

[Recent advances in the development of vaccines against hemorrhagic fevers caused by arenaviruses].

Medecine sciences : M/S, 2023
Arenaviruses are a global threat, causing thousands of deaths each year in several countries around the world. Despite strong efforts in the development of vaccine candidates, vaccines against Lassa fever or Bolivian and Venezuelan hemorrhagic fevers are
Mathieu Mateo, S. Baize
semanticscholar   +1 more source

Targeting of arenavirus RNA synthesis by a carboxamide-derivatized aromatic disulfide with virucidal activity. [PDF]

, 2013
Several arenaviruses can cause severe hemorrhagic fever (HF) in humans, representing a public health threat in endemic areas of Africa and South America.
Damonte, Elsa Beatriz, Garcia, Cybele, Levingston Mac Leod, Jesica Mariana, Lopez, Nora Mabel, Sepúlveda, Claudia Soledad   +4 more
core   +9 more sources

Inhibition of Arenaviruses by Combinations of Orally Available Approved Drugs

Antimicrobial Agents and Chemotherapy, 2021
Neglected diseases caused by arenaviruses such as Lassa virus (LASV) and filoviruses like Ebola virus (EBOV) primarily afflict resource-limited countries, where antiviral drug development is often minimal.
Shawn Herring, J. M. Oda, J. Wagoner, D. Kirchmeier, Aidan O’Connor, Elizabeth A. Nelson, Qinfeng Huang, Yuying Liang, Lisa Evans DeWald, L. Johansen, P. Glass, G. Olinger, A. Ianevski, T. Aittokallio, M. Paine, S. Fink, J. White, S. Polyak   +17 more
semanticscholar   +1 more source

Generation of Reporter-Expressing New World Arenaviruses: A Systematic Comparison

Viruses, 2022
Replication-competent reporter-expressing viruses are crucial tools in molecular virology with applications that range from antiviral screening to live-cell imaging of protein spatiotemporal dynamics.
Lucie Fénéant, A. Leske, Karla Günther, A. Groseth   +3 more
semanticscholar   +1 more source

Understanding Host–Virus Interactions: Assessment of Innate Immune Responses in Mastomys natalensis Cells after Arenavirus Infection

Viruses, 2022
Mastomys natalensis is the natural host of various arenaviruses, including the human-pathogenic Lassa virus. Homologous arenaviruses, defined here as those having M. natalensis as a natural host, can establish long-lasting infection in M.
Nele Marie Brinkmann, Chris Hoffmann, Stephanie Wurr, Elisa Pallasch, Julia Hinzmann, Eleonore Ostermann, Wolfram Brune, Maria Elisabeth Eskes, Lukas Jungblut, Stephan Günther, Ludmilla Unrau, Lisa Oestereich   +11 more
doaj   +1 more source