Results 51 to 60 of about 8,104 (224)

Host-species transferrin receptor 1 orthologs are cellular receptors for nonpathogenic new world clade B arenaviruses.

PLoS Pathogens, 2009
The ability of a New World (NW) clade B arenavirus to enter cells using human transferrin receptor 1 (TfR1) strictly correlates with its ability to cause hemorrhagic fever.
Jonathan Abraham, Jo Ann Kwong, César G Albariño, Jiajie G Lu, Sheli R Radoshitzky, Jorge Salazar-Bravo, Michael Farzan, Christina F Spiropoulou, Hyeryun Choe   +8 more
doaj   +1 more source

Polyfunctional CD4+ T cell responses to a set of pathogenic arenaviruses provide broad population coverage [PDF]

, 2010
Background Several arenaviruses cause severe hemorrhagic fever and aseptic meningitis in humans for which no licensed vaccines are available. A major obstacle for vaccine development is pathogen heterogeneity within the Arenaviridae family.
Maya F Kotturi, Jason Botten, Matt Maybeno, John Sidney, Jean Glenn, Huynh-Hoa Bui, Carla Oseroff, Shane Crotty, Bjoern Peters, Howard Grey, Daniel M Altmann, Michael J Buchmeier, Alessandro Sette   +12 more
core   +2 more sources

Three arenaviruses in three subspecific natal multimammate mouse taxa in Tanzania: same host specificity, but different spatial genetic structure?

Virus Evolution, 2020
Mastomys natalensis is widespread in sub-Saharan Africa and hosts several arenavirus species, including the pathogenic zoonotic Lassa virus in West Africa. Mitochondrial lineages sub-divide the range of M. natalensis and have been associated with cryptic
L. Cuypers, S. Baird, Alexandra Hánová, Tatjana Locus, Abdul S. Katakweba, S. Gryseels, J. Bryja, H. Leirs, J. Goüy de Bellocq   +8 more
semanticscholar   +1 more source

Arenavirus Variations Due to Host-Specific Adaptation

Viruses, 2013
Arenavirus particles are enveloped and contain two single-strand RNA genomic segments with ambisense coding. Genetic plasticity of the arenaviruses comes from transcription errors, segment reassortment, and permissive genomic packaging, and results in ...
Juan C. Zapata, Maria S. Salvato
doaj   +1 more source

Molecular characterization of a new highly divergent Mobala related arenavirus isolated from Praomys sp. rodents

Scientific Reports, 2021
Arenaviruses represent a family of viruses that are naturally present in rodents belonging to subfamily Murinae, Neotominae or Sigmodontinae. Except for Lassa virus, little information is available on other Old-World arenaviruses.
Huguette Simo Tchetgna, Stephane Descorps-Declère, Benjamin Selekon, Aurelia Kwasiborski, Mathias Vandenbogaert, Jean-Claude Manuguerra, Antoine Gessain, Valérie Caro, Emmanuel Nakouné, Nicolas Berthet   +9 more
doaj   +1 more source

Validation of Сhoice of Laboratory Model for Preclinical Estimation of Medical Protectors Against Bolivian Hemorrhagic Fever

Вестник войск РХБ защиты, 2023
This review is dedicated to the peculiarities of pathogenesis of the experimental Bolivian hemorrhagic fever (BHF) - the disease, caused by Machupo virus (Arenaviridae family).
T. E. Sizikova, V. N. Lebedev, V. B. Pantukhov, E. Y. Vakhnov, S. V. Borisevich   +4 more
doaj   +1 more source

Topoisomerase II as a Novel Antiviral Target against Panarenaviral Diseases

Viruses, 2022
Although many arenaviruses cause severe diseases with high fatality rates each year, treatment options are limited to off-label use of ribavirin, and a Food and Drug Administration (FDA)-approved vaccine is not available.
Tosin Oladipo Afowowe, Yasuteru Sakurai, Shuzo Urata, Vahid Rajabali Zadeh, Jiro Yasuda   +4 more
doaj   +1 more source

Interaction of silver nanoparticles with Tacaribe virus [PDF]

, 2010
Background Silver nanoparticles possess many unique properties that make them attractive for use in biological applications. Recently they received attention when it was shown that 10 nm silver nanoparticles were bactericidal, which is ...
Janice L Speshock, Richard C Murdock, Laura K Braydich-Stolle, Amanda M Schrand, Saber M Hussain   +4 more
core   +2 more sources

Recombinant Pichinde reporter virus as a safe and suitable surrogate for high-throughput antiviral screening against highly pathogenic arenaviruses

bioRxiv
Several arenaviruses, such as the Old World (OW) Lassa virus (LASV) and the New World (NW) Junin virus (JUNV), can cause severe and lethal viral hemorrhagic fevers in humans.
Carolina Q. Sacramento, Ryan Bott, Qinfeng Huang, Brett Eaton, Elena Postnikova, A. J. Sabir, Malaika D. Argade, K. Ratia, Manu Anantpadma, Paul R. Carlier, H. Ly, Yuying Liang, Lijun Rong   +12 more
semanticscholar   +1 more source

Sympatric Occurrence of 3 Arenaviruses, Tanzania

Emerging Infectious Diseases, 2010
To determine the specificity of Morogoro virus for its reservoir host, we studied its host range and genetic diversity in Tanzania. We found that 2 rodent species other than Mastomys natalensis mice carry arenaviruses. Analysis of 340 nt of the viral RNA
Joëlle Goüy de Bellocq, Benny Borremans, Abdul Katakweba, Rhodes Makundi, Stuart J.E. Baird, Beate Becker-Ziaja, Stephan Günther, Herwig Leirs   +7 more
doaj   +1 more source