Results 121 to 130 of about 5,976,322 (209)

The role of arginase I and II in the vasculature

, 2017
The work presented in this thesis focuses on the enzyme arginase, and the role it plays in regulating NO bioavailability in the vasculature as well as in the progression of atherosclerosis.
Khong, Sacha (3718567)
core   +1 more source

Integrative Approaches in Cardiovascular Disease: The Role of Nutraceuticals in Heart Failure, Atrial Fibrillation, and Related Conditions

Phytotherapy Research, EarlyView.
Schematic representation of the shared pathophysiological mechanisms underlying heart failure (HF) and atrial fibrillation (AF), including inflammation, oxidative stress, endothelial dysfunction, and fibrosis. The figure highlights the clinical and mechanistic convergence of conventional pharmacological therapies and selected nutraceuticals in ...
Laura Beatrice Mattioli, Ivan Corazza, Roberta Budriesi, Luca Camarda, Maria Carelli, Alberto Spadotto, Igor Diemberger   +6 more
wiley   +1 more source

Protective Potentials of Natural Products Against Vascular Dementia: A Comprehensive Review of Experimental Studies

Phytotherapy Research, EarlyView.
ABSTRACT Vascular dementia (VaD), accounting for up to 20% of dementia cases globally, is primarily driven by chronic cerebral hypoperfusion (CCH), which leads to progressive cognitive impairment. Despite the increasing prevalence of VaD, effective treatments remain limited.
Jung‐Hoon Kim, Yongtaek Oh, Suin Cho
wiley   +1 more source

Arginase II Promotes Macrophage Inflammatory Responses Through Mitochondrial Reactive Oxygen Species, Contributing to Insulin Resistance and Atherogenesis

, 2012
Macrophage-mediated chronic inflammation is mechanistically linked to insulin resistance and atherosclerosis. Although arginase I is considered antiinflammatory, the role of arginase II (Arg-II) in macrophage function remains elusive.
Scherrer, Urs, Scerri, Isabelle, Popp, Katja, Rajapakse, Angana G, Carvas, João M, Ming, Xiu-Fen, Yepuri, Gautham, Li, Jianhui, Sartori, Claudio, Kwak, Brenda R, Wu, Zongsong, Ruffieux, Jean, Montani, Jean-Pierre, Xiong, Yuyan, Yang, Zhihong   +14 more
core  

Regulatory role of arginase I and II in nitric oxide, polyamine, and proline syntheses in endothelial cells

, 2001
Endothelial cells (EC) metabolize l-arginine mainly by arginase, which exists as two distinct isoforms, arginase I and II. To understand the roles of arginase isoforms in EC arginine metabolism, bovine coronary venular EC were stably transfected with the
Sidney M. Morris, Cynthia J. Meininger, Tony E. Haynes, Guoyao Wu, James R. Hawker, Diane Kepka-Lenhart, Hui Li, Sanjay K. Mistry   +7 more
core   +1 more source

Natural Products Exhibit Therapeutic Potential in Treating Rheumatoid Arthritis by Targeting the PI3K/Akt Signaling Pathway

Phytotherapy Research, EarlyView.
This review summarizes how natural products, mainly including flavonoids, terpenoids, alkaloids, and polyphenols alleviate RA via PI3K/Akt pathway, regulating inflammation, proliferation, apoptosis, angiogenesis, and osteoclast differentiation. The figure was created by Figdraw (https://www.figdraw.com/#/).
Haishuo Ren, Yige Wang, Wenjing Ma, Omachi Daniel Ogaji, Shujing Chen, Kunze Du, Xuemi Zhang, Bo Xu, Shanxing Zhai, Shiming Fang, Yanxu Chang   +10 more
wiley   +1 more source

Natural Polysaccharides for Rheumatoid Arthritis Therapy: Mechanism, Drug Delivery and Clinical Application

Phytotherapy Research, EarlyView.
Schematic overview of the experimental models, therapeutic mechanisms, drug delivery systems, and clinical potential of natural polysaccharides in rheumatoid arthritis. ABSTRACT Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized primarily by chronic synovitis.
Luxin Li, Junnan Li, Guangzhi Li, Lili Huang, Tiantian Wen, Yanying Li, Yan Sun, Zhenqiang Liu, Qingshan Chen, Lili Zhang, Tiangang Lu, Ruiyan Wu, Haixue Kuang, Xiaochi Ma, Yan Liu   +14 more
wiley   +1 more source

Arginase II inhibition prevents nitrate tolerance

, 2012
BACKGROUND AND PURPOSE Nitrate tolerance, the loss of vascular responsiveness with continued use of nitrates, remains incompletely understood and is a limitation of these therapeutic agents.
S Khong (13725661), A Aprico (13691092), G Dusting (13715761), D Kaye (13321494), Kylie Venardos (13053762), D Michell (13725667), M Zarei (13454934), J Chin-Dusting (13691491), K Andrews (13555651), N Huynh (13725664), K Moe (13725670)   +10 more
core  

Human Arginase II:  Crystal Structure and Physiological Role in Male and Female Sexual Arousal^†,‡

, 2016
Arginase is a binuclear manganese metalloenzyme that catalyzes the hydrolysis of l-arginine to form l-ornithine and urea. The X-ray crystal structure of a fully active, truncated form of human arginase II complexed with a boronic acid transition state ...
Noel N. Kim (2947923), Frances A. Emig (2947932), Abdulmaged M. Traish (2947926), David E. Ash (2947920), Evis Cama (2947938), Soo Woong Kim (629122), Hyunshun Shin (2947929), Diana M. Colleluori (2947935), David W. Christianson (1294293)   +8 more
core   +1 more source

Arginase II Plays a Central Role in the Sexual Dimorphism of Arginine Metabolism in C57BL/6 Mice. [PDF]

J Nutr, 2020
Mohammad MA, Didelija IC, Marini JC.
europepmc   +1 more source