Results 41 to 50 of about 130,955 (165)

EBV‐Driven ODC1 Upregulation Enhances Polyamine Anabolism to Promote Viral Replication and Cisplatin Resistance in Nasopharyngeal Carcinoma

Advanced Science, EarlyView.
EBV‑BZLF1 initiates ODC1‑driven polyamine anabolism that correlates with poor clinical prognosis in nasopharyngeal carcinoma. The ODC1–spermidine axis promotes viral replication, cell proliferation and innate immune evasion. Pharmacological inhibition of ODC1 rescues cisplatin sensitivity, establishing ODC1 as a viable therapeutic target for EBV ...
Yueshuo Li, Xudong Hu, Chenxing Yang, Na Liu, Lin Wang, Xi Cai, Min Tang, Ya Cao, Li Shang, Feng Shi   +9 more
wiley   +1 more source

Biosynthetic arginine decarboxylase in phytopathogenic fungi.

, 1989
It has been reported that while bacteria and higher plants possess two different pathways for the biosynthesis of putrescine, via ornithine decarboxylase (ODC) and arginine decarboxylase (ADC); the fungi, like animals, only use the former pathway.
Minocha, Subhash C., Khan, Akhtar Jamal
core   +1 more source

Structural Study of Agmatine Iminohydrolase From Medicago truncatula, the Second Enzyme of the Agmatine Route of Putrescine Biosynthesis in Plants

Frontiers in Plant Science, 2019
Plants are unique eukaryotes that can produce putrescine (PUT), a basic diamine, from arginine via a three-step pathway. This process starts with arginine decarboxylase that converts arginine to agmatine.
Bartosz Sekula, Zbigniew Dauter
doaj   +1 more source

TH17–Associated Polyamine Metabolism‐Guided Nanozyme Promotes Alveolar Bone Repair in Periodontitis

Advanced Science, EarlyView.
A pronounced TH17‐skewed immune response is identified in experimental periodontitis, and enrichment of the polyamine pathway is observed during TH17 differentiation, suggesting its potential as an immunometabolic target. Inspired by these findings, DFMO@Ui‐Mn is developed as a therapeutic platform combining cascade ROS scavenging with immunometabolic ...
Cheng Zhu, Tiancheng Li, Yu Jin, Yixin Li, Qicheng Liu, Runzhe Fang, Luyao Qu, Xinyue Tang, Ruomei Li, Xiaoyue Zhao, Jin Hao, Bing Fang, Lunguo Xia   +12 more
wiley   +1 more source

Synergistic effect of carbon nanoparticles with mild salinity for improving chemical composition and antioxidant activities of radish sprouts

Frontiers in Plant Science, 2023
The demand for healthy foods with high functional value has progressively increased. Carbon nanoparticles (CNPs) have a promising application in agriculture including the enhancement of plant growth.
Riyadh F. Halawani, Hamada AbdElgawad, Fahed A. Aloufi, Mansour A. Balkhyour, Ahlem Zrig, Ahlem Zrig, Abdelrahim H.A. Hassan, Abdelrahim H.A. Hassan   +7 more
doaj   +1 more source

The Cancer Cell Metabolic Reprogramming Remodels the Tumor Microenvironment: Molecular Mechanisms and Therapeutic Strategies

Advanced Science, EarlyView.
This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang, Zhicheng Zhou, Xue Jiang, Zhenguang Du, Yangyang Zhan, Xinli Liu   +5 more
wiley   +1 more source

Impact and mechanisms of cinnamaldehyde on putrescine production by Obesumbacterium proteus OP216735 during the process of Xinjiang sausage

Food Science and Human Wellness
This study investigated the effects of cinnamaldehyde on putrescine production by Obesumbacterium proteus in pure cultures and Xinjiang sausage. Scanning electron microscopy was used to analyze the cell morphology of the test bacteria, and reverse ...
Honghong Yu, Shiyi Zhu, Shiling Lu
doaj   +1 more source

Crystal structure of the acid-induced arginine decarboxylase from Escherichia coli: reversible decamer assembly controls enzyme activity.

, 2009
The acid-induced arginine decarboxylase is part of an enzymatic system in Escherichia coli that contributes to making this organism acid resistant. The arginine decarboxylase is a vitamin B(6)-dependent enzyme that is active at acidic pH.
Carpenter, EP, Maher, Megan J., Carpenter, Elisabeth P., Palmer, Tracy, Andréll, J, Iwata, S, Maher, MJ, Carpenter, Elizabeth, Palmer, T, Iwata, So, Hicks, MG, Andrell, Juni, Hicks, Matthew G.   +12 more
core   +1 more source

Amino Acid and Biogenic Amine Profiles in Sausages Reformulated With Processed, Fermented Oyster Mushrooms

ChemFoodChem, EarlyView.
This research showed that sausage reformulation preserves high essential amino acid and branched‐chain amino acid content, as well as increasing free amino acids (FAA) related to umami flavor and health‐promoting components such as GABA in the products.
Albert Gashi, György Kenesei, Meltem Boylu Kovács, Zsuzsanna Mednyánszky, Livia Simon Sarkadi   +4 more
wiley   +1 more source

Spermidine-Regulated Biosynthesis of Heat-Stable Antifungal Factor (HSAF) in Lysobacter enzymogenes OH11

Frontiers in Microbiology, 2018
Heat-Stable Antifungal Factor (HSAF) and its analogs are antifungal natural products produced by the biocontrol agent Lysobacter enzymogenes. The production of HSAF is greatly influenced by environmental stimuli and nutrients, but the underlying ...
Yuan Chen, Yuan Chen, Lingjun Yu, Lingjun Yu, Fengquan Liu, Liangcheng Du   +5 more
doaj   +1 more source