Results 111 to 120 of about 47,693 (305)
Insect Science, EarlyView.This study introduces a microinjection technique to deliver dsRNA into the hemolymph of first instar larval thrips (L1s) via the foreleg coxa, enhancing survival rates by minimizing internal tissue damage. Significant knockdown of V‐ATPase‐B, CYP3653A2, and ApoLp‐II/I was achieved, with silencing of CYP3653A2 or ApoLp‐II/I increasing larval mortality ...
Jinlong Han, Dorith Rotenberg
wiley +1 more source
RNA Interference by Single- and Double-stranded siRNA With a DNA Extension Containing a 3′ Nuclease-resistant Mini-hairpin Structure [PDF]
, 2009 Selective gene silencing by RNA interference (RNAi) involves double-stranded small interfering RNA (ds siRNA) composed of single-stranded (ss) guide and passenger RNAs.
Allison, Simon J., Milner, Jo
core +6 more sources
Progress in micro RNA focused research in endocrinology
Endocrine Regulations, 2016 Micro RNAs (miRNAs) are small regulatory molecules of increasing biologists’ interest. miRNAs, unlikely mRNA, do not encode proteins. It is a class of small double stranded RNA molecules that via their seed sequence interact with mRNA and inhibit its ...
Voglova K., Bezakova J., Herichova Iveta
doaj +1 more source
Arboviruses and the challenge to establish systemic and persistent infections in competent mosquito vectors : the interaction with the RNAi mechanism [PDF]
, 2019 Arboviruses are capable to establish long-term persistent infections in mosquitoes that do not affect significantly the physiology of the insect vectors. Arbovirus infections are controlled by the RNAi machinery via the production of viral siRNAs and the
Kolliopoulou, Anna +3 more
core +1 more source
Cell Proliferation, EarlyView.tRF‐3a is the main tsRNA subtype up‐regulated in HBV‐related HCC. tRF‐3a‐Pro is significantly up‐regulated in HBV‐related HCC tumour than that in paratumour tissues. The level of tRF‐3a‐Pro in serum is a promising candidate biomarker for HCC diagnosis. tRF‐3a‐Pro promotes cell proliferation and regulates cell cycle of HCC.
Jingyi Si +7 more
wiley +1 more source
Domain motions of Argonaute, the catalytic engine of RNA interference
BMC Bioinformatics, 2007 Background The Argonaute protein is the core component of the RNA-induced silencing complex, playing the central role of cleaving the mRNA target. Visual inspection of static crystal structures already has enabled researchers to suggest conformational ...
Wall Michael E +2 more
doaj +1 more source
Functional Analysis of MicroRNA Pathway Genes in the Somatic Gonad and Germ Cells During Ovulation in \u3cem\u3eC. Elegans\u3c/em\u3e [PDF]
, 2017 MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression that play critical roles in animal development and physiology, though functions for most miRNAs remain unknown.
Abbott, Allison L. +3 more
core +1 more source
microRNAs of parasitic helminths – identification, characterization and potential as drug targets [PDF]
, 2014 microRNAs (miRNAs) are small non-coding RNAs involved in post-transcriptional gene regulation. They were first identified in the free-living nematode Caenorhabditis elegans, where the miRNAs lin-4 and let-7 were shown to be essential for regulating ...
Britton, Collette +3 more
core +1 more source
Insecticide resistance management scenarios differ for RNA‐based sprays and traits
Insect Molecular Biology, EarlyView.dsRNA insecticides are developed as transgenic traits or sprays. IRM for dsRNA traits is based on stacked modes of action and a refuge. IRM for dsRNA sprays is based on rotating dsRNA with different modes of action insecticides. Abstract RNA‐based bioinsecticides that comprise a dsRNA active ingredient and function by RNA interference (RNAi) are being ...
Kenneth Narva +8 more
wiley +1 more source
Insect Molecular Biology, EarlyView.Colorado potato beetle's RNA interference (RNAi) response was enhanced when insecticidal dsactin was consumed at high temperatures. The enhanced RNAi outcomes at high temperatures were not a function of dose or the expression of core RNAi genes. The potato cultivar consumed by Colorado potato beetle larvae did not affect RNAi outcomes, but larvae did ...
Mike Darrington +6 more
wiley +1 more source