Results 91 to 100 of about 2,680,620 (246)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

OMUNIKASI SAINSPESETA DIDIK MELAUI PEMBELAJARANA ARGUMENT DRIVEN INQUIRY BERBANTUAN ARGUMENT MAPPING PADA KONSEP PENCEMARAN LINGKUNGAN [PDF]

, 2023
The purpose of this study is to find out how the Argument Driven Inquiry model assisted by Argument Mapping has an impact on students' science communication skills in the concept of environmental pollution material, with its urgency due to the large ...
Juhanda, Aa, Wahyudin, Siti Nur Azizah, Windyariani, Sistiana   +2 more
core  

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Research Trends in Argumentation Skills in Indonesian Science Education: A Systematic Review of Models, Subjects, and Learning Topics

Indonesian Journal of Educational Research and Review
Argumentation skills are one of the important competencies of the 21st century that play a role in building conceptual understanding and critical thinking skills.
Umi Kalsum Djano, Nur Azizah Dj. Junus, Duden Saepuzaman, Muslim   +3 more
doaj   +3 more sources

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

PENERAPAN ARGUMENT DRIVEN INQUIRY BERBANTUAN ARGUMENT MAPS UNTUK MENINGKATKAN KEMAMPUAN KOGNITIF DAN MENGIDENTIFIKASI LEVEL ARGUMENTASI SISWA MA PADA MATERI GERAK HARMONIK SEDERHANA [PDF]

, 2017
Tujuan dari penelitian ini adalah memperoleh gambaran peningkatan kemampuan kognitif dan level argumentasi siswa setelah diterapkan pembelajaran argument driven inquiry berbantuan argument maps dan pembelajaran argument driven inquiry tanpa berbantuan ...
Roza, Jasmi
core  

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Peningkatan kemampuan argumentasi tertulis siswa melalui pembelajaran argument driven inquiry pada pembelajaran IPA terpadu di SMP kelas VII

, 2023
ABSTRAKSalah satu keterampilan yang dapat di latihkan agar siswa-siswa menjadi manusia yang dapat berkontribusi bagi masyarakat dan memiliki kemampuan berkomunikasi adalah keterampilan untuk beragumentasi secara ilmiah.
Andriani, Yuli
core  

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source