Results 91 to 100 of about 4,305 (234)

Palmitoylation of acetylated tubulin and association with ceramide-rich platforms is critical for ciliogenesis

Journal of Lipid Research, 2021
: Microtubules are polymers composed of αβ-tubulin subunits that provide structure to cells and play a crucial role in in the development and function of neuronal processes and cilia, microtubule-driven extensions of the plasma membrane that have sensory
Priyanka Tripathi, Zhihui Zhu, Haiyan Qin, Ahmed Elsherbini, Simone M. Crivelli, Emily Roush, Guanghu Wang, Stefka D. Spassieva, Erhard Bieberich   +8 more
doaj  

In Vitro Modeling Using Ciliopathy-Patient-Derived Cells Reveals Distinct Cilia Dysfunctions Caused by CEP290 Mutations

Cell Reports, 2017
Mutations in CEP290, a transition zone protein in primary cilia, cause diverse ciliopathies, including Leber congenital amaurosis (LCA) and Joubert-syndrome and related disorders (JSRD).
Hiroko Shimada, Quanlong Lu, Christine Insinna-Kettenhofen, Kunio Nagashima, Milton A. English, Elizabeth M. Semler, Jacklyn Mahgerefteh, Artur V. Cideciyan, Tiansen Li, Brian P. Brooks, Meral Gunay-Aygun, Samuel G. Jacobson, Tiziana Cogliati, Christopher J. Westlake, Anand Swaroop   +14 more
doaj   +1 more source

Primary Cilia as a Biomarker in Mesenchymal Stem Cells Senescence: Influencing Osteoblastic Differentiation Potency Associated with Hedgehog Signaling Regulation

Stem Cells International, 2021
Bone tissue engineering-based therapy for bone lesions requires the expansion of seeding cells, such as autologous mesenchymal stem cells (MSCs). A major obstacle to this process is the loss of the phenotype and differentiation capacity of MSCs subjected
Su Fu, Chunlin Zhang, Xu Yan, Dongzhe Li, Yongkui Wang, Chao Dong, Zhengming Cao, Yongming Ning, Chenglong Shao, Tengyue Yang   +9 more
doaj   +1 more source

Primary Cilia in the Pathogenic Mouse Brain & EEG Waveform Analysis of a Mouse Model of Alzheimer\u27s Disease [PDF]

, 2022
In the last two decades, primary cilia have become recognized as tiny sensory organelles with considerable physiological function including regulation of cell division and modulation of transduction pathways.
Sterpka, Ashley Diemand
core   +1 more source

Human efferent ductules and epididymis display unique cell lineages with motile and primary cilia

Andrology, Volume 13, Issue 4, Page 894-910, May 2025.
Abstract Background Previous research has illustrated the role of cilia as mechanical and sensory antennae in various organs within the mammalian male reproductive system across different developmental stages. Despite their significance in both organ development and homeostasis, primary cilia in the human male reproductive excurrent duct have been ...
Ludovic Vinay, Rex A. Hess, Clémence Belleannée   +2 more
wiley   +1 more source

IMPDH2's Central Role in Cellular Growth and Diseases: A Potential Therapeutic Target

Cell Proliferation, EarlyView.
IMPDH2 is a rate‐limiting enzyme in guanine nucleotide biosynthesis. It plays diverse roles in various physiological and pathological processes: nucleotide metabolism, inflammation, immune function, ribosomal stress. Structural or regulatory alterations in IMPDH2 are linked to significant health issues, and critical relevance in disease progression. We
Zheng Li, Yunpeng Zou, Jiayao Niu, Ying Zhang, Aohua Yang, Wenyu Lin, Jie Guo, Shuya Wang, Ronghan Liu   +8 more
wiley   +1 more source

Ciliary phenotyping in renal epithelial cells in a cranioectodermal dysplasia patient with WDR35 variants

Frontiers in Molecular Biosciences, 2023
Background: Cranioectodermal dysplasia (CED) is a skeletal autosomal recessive ciliopathy. The characteristic clinical features of CED are facial dysmorphisms, short limbs, narrow thorax, brachydactyly, ectodermal abnormalities, and renal insufficiency ...
Joanna Walczak-Sztulpa, Anna Wawrocka, Łukasz Kuszel, Paulina Pietras, Marta Leśniczak-Staszak, Mirosław Andrusiewicz, Maciej R. Krawczyński, Anna Latos-Bieleńska, Marta Pawlak, Ryszard Grenda, Anna Materna-Kiryluk, Machteld M. Oud, Machteld M. Oud, Witold Szaflarski   +13 more
doaj   +1 more source

CEP162: A critical regulator of ciliary transition zone assembly and its implications in ciliopathies

Journal of Cell Communication and Signaling, Volume 19, Issue 2, June 2025.
Abstract CEP162, a 162‐kDa centrosome protein, is a crucial centrosomal adapter, mediating cell differentiation and polarization. CEP162 maintains mitosis by dynamically stabilizing microtubules. CEP162 promotes the transition zone (TZ) assembly in the basal body through interaction with CEP131, CEP290, and axoneme microtubules as well as the distal ...
Jun Yin, Jialian Bai, Xiaochong He, Wenjuan He, Hongming Miao, Mengjie Zhang, Zhongying Yu, Bing Ni   +7 more
wiley   +1 more source

Aurora kinase A inhibition plus Tumor Treating Fields suppress glioma cell proliferation in a cilium-independent manner. [PDF]

Transl Oncol
Tumor Treating Fields (TTFields) extend the survival of glioblastoma (GBM) patients by interfering with a broad range of tumor cellular processes. Among these, TTFields disrupt primary cilia stability on GBM cells.
Tian J, Mallinger JC, Shi P, Ling D, Deleyrolle LP, Lin M, Khoshbouei H, Sarkisian MR.   +7 more
europepmc   +2 more sources

TRIP6 functions in brain ciliogenesis [PDF]

, 2021
TRIP6, a member of the ZYXIN-family of LIM domain proteins, is a focal adhesion compo- nent. Trip6 deletion in the mouse, reported here, reveals a function in the brain: ependymal and choroid plexus epithelial cells are carrying, unexpectedly,
Frappart, Lucien, Grigaravicius, Paulius, Haenold, Ronny, Herrlich, Peter, Heuer, Heike, Kassel, Olivier, Min, Woo Kee, Monajembashi, Shamci, Nagel, Sigrun, Ploubidou, Aspasia, Shukla, Shalmali, Tapias, Alicia, Urbánek, Pavel, Wang, Zhao-Qi   +13 more
core   +2 more sources