Results 91 to 100 of about 2,827 (178)

Serotonin 5-HT6 receptors affect cognition in a mouse model of Alzheimer’s disease by regulating cilia function

Alzheimer’s Research & Therapy, 2017
Background Serotonin receptor 5-HT6 is involved in cognition and Alzheimer’s disease (AD) development. However, the mechanism of 5-HT6 in AD pathology is not clear.
Lili Hu, Bingjie Wang, Yan Zhang
doaj   +1 more source

Cilia proteins are biomarkers of altered flow in the vasculature

JCI Insight, 2022
Cilia, microtubule-based organelles that project from the apical luminal surface of endothelial cells (ECs), are widely regarded as low-flow sensors. Previous reports suggest that upon high shear stress, cilia on the EC surface are lost, and more recent ...
Ankan Gupta, Karthikeyan Thirugnanam, Madhan Thamilarasan, Ashraf M. Mohieldin, Hadeel T. Zedan, Shubhangi Prabhudesai, Meghan R. Griffin, Andrew D. Spearman, Amy Pan, Sean P. Palecek, Huseyin C. Yalcin, Surya M. Nauli, Kevin R. Rarick, Rahima Zennadi, Ramani Ramchandran   +14 more
doaj   +1 more source

Primary cilia modulate TLR4-mediated inflammatory responses in hippocampal neurons

Journal of Neuroinflammation, 2017
Background The primary cilium is an organelle that can act as a master regulator of cellular signaling. Despite the presence of primary cilia in hippocampal neurons, their function is not fully understood.
Hyunjung Baek, Hyo Jung Shin, Jwa-Jin Kim, Nara Shin, Sena Kim, Min-Hee Yi, Enji Zhang, Jinpyo Hong, Joon Won Kang, Yonghyun Kim, Cuk-Seong Kim, Dong Woon Kim   +11 more
doaj   +1 more source

ARL13B, a Joubert Syndrome-Associated Protein, Is Critical for Retinogenesis and Elaboration of Mouse Photoreceptor Outer Segments [PDF]

, 2018
Tanya L. Dilan, Abigail R. Moye, Ezequiel M. Salido, Thamaraiselvi Saravanan, Saravanan Kolandaivelu, Andrew F.X. Goldberg, Visvanathan Ramamurthy   +6 more
openalex   +1 more source

Supplemental Materials and Figure Legends from Arl13b Promotes Gastric Tumorigenesis by Regulating Smo Trafficking and Activation of the Hedgehog Signaling Pathway

, 2023
Jia Shao, Linlin Xu, Limin Chen, Quqin Lu, Xinsheng Xie, Wei Shi, Huanting Xiong, Chao Shi, Xuan Huang, Jinhong Mei, Hai Rao, Hua Lu, Nonghua Lü, Shiwen Luo   +13 more
openalex   +1 more source

Ciliary Genes arl13b , ahi1 and cc2d2a Differentially Modify Expression of Visual Acuity Phenotypes but do not Enhance Retinal Degeneration due to Mutation of cep 290 in Zebrafish [PDF]

, 2019
Emma M. Lessieur, Ping Song, Gabrielle C Nivar, Ellen Piccillo, Joseph Fogerty, Richard Rozic, Brian D. Perkins   +6 more
openalex   +1 more source

Abstracts

Molecular Oncology, Volume 19, Issue S1, Page 1-940, June 2025.
Abstracts submitted to the ‘EACR 2025 Congress: Innovative Cancer Science’, from 16–19 June 2025 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

Data from Arl13b Promotes Gastric Tumorigenesis by Regulating Smo Trafficking and Activation of the Hedgehog Signaling Pathway

, 2023
Jia Shao, Linlin Xu, Limin Chen, Quqin Lu, Xinsheng Xie, Wei Shi, Huanting Xiong, Chao Shi, Xuan Huang, Jinhong Mei, Hai Rao, Hua Lu, Nonghua Lü, Shiwen Luo   +13 more
openalex   +2 more sources

Joubert syndrome: report of 11 cases

The Turkish Journal of Pediatrics, 2012
Joubert syndrome (JS) is an autosomal recessive condition characterized by hypotonia, ataxia, psychomotor delay, and variable occurrence of oculomotor apraxia and neonatal breathing abnormalities.
Faruk İncecik, M Özlem Hergüner, Şakir Altunbaşak, Joseph G Gleeson   +3 more
doaj  

Biochemical characterization of purified mammalian ARL13B protein indicates that it is an atypical GTPase and ARL3 guanine nucleotide exchange factor (GEF) [PDF]

, 2017
Anna Ivanova, Tamara Caspary, Nicholas T. Seyfried, Duc M. Duong, Andrew B. West, Zhiyong Liu, Richard Kahn   +6 more
openalex   +1 more source