N6‐Methyladenosine Regulates Cilia Elongation in Cancer Cells by Modulating HDAC6 Expression
Advanced Science, Volume 12, Issue 2, January 13, 2025.METTL3 positively regulates the translation of HDAC6 in an m6A‐dependent manner. Briefly, m6A methylation of A3678 in CDS ameliorates its translation efficiency by facilitating the binding with YTHDF3. Depletion of METTL3‐mediated m6A modification promotes cilia elongation and acetylation of α‐tubulin.
Yalan Rui +13 more
wiley +1 more source
Characterization of Primary Cilia Formation in Human ESC-Derived Retinal Organoids
Stem Cells International, 2023 Objectives. Primary cilia are conserved organelles found in polarized mammalian cells that regulate neuronal growth, migration, and differentiation. Proper cilia formation is essential during eye development. Our previous reports found that both amacrine
Ke Ning +8 more
doaj +1 more source
Shear stress effects on epididymal epithelial cell via primary cilia mechanosensory signaling
Journal of Cellular Physiology, Volume 240, Issue 1, January 2025.Influence of shear stress on epididymis epithelial cells through primary cilia mechanosensory signaling. (a) Anatomical illustration of the male reproductive system highlighting the epididymis three main segments: caput, corpus, and cauda. (b) Luminal fluid flow‐induced shear stress within the epididymal duct.
Sepideh Fakhari +8 more
wiley +1 more source
Direct recording and molecular identification of the calcium channel of primary cilia [PDF]
, 2014 Summary A primary cilium is a solitary slender non-motile protuberance of structured microtubules (9+0) enclosed by plasma membrane1. Housing components of the cell division apparatus between cell divisions, they also serve as specialized compartments ...
Clapham, David E. +3 more
core +1 more source
Physiological Reports, Volume 13, Issue 2, January 2025.Abstract Polycystic kidney diseases (PKD) are genetic disorders which disrupt kidney architecture and function. Autosomal recessive PKD (ARPKD) is a rare form of PKD, caused by mutations in PKHD1, and clinically more severe than the more common autosomal dominant PKD (ADPKD).
Lauren G. Russell +11 more
wiley +1 more source
Axonemal Lumen Dominates Cytosolic Protein Diffusion inside the Primary Cilium [PDF]
, 2017 Transport of membrane and cytosolic proteins in primary cilia is thought to depend on intraflagellar transport (IFT) and diffusion. However, the relative contribution and spatial routes of each transport mechanism are largely unknown.
Lim, RYH +7 more
core +3 more sources
Role for the IFT-A Complex in Selective Transport to the Primary Cilium
Cell Reports, 2016 Intraflagellar transport sub-complex A (IFT-A) is known to regulate retrograde IFT in the cilium. To rigorously assess its other possible roles, we knocked out an IFT-A subunit, IFT121/WDR35, in mammalian cells and screened the localization of more than ...
Wenxiang Fu +4 more
doaj +1 more source
A systems-biology approach to understanding the ciliopathy disorders. [PDF]
, 2011 'Ciliopathies' are an emerging class of genetic multisystemic human disorders that are caused by a multitude of largely unrelated genes that affect ciliary structure/function.
Gleeson, Joseph G, Lee, Ji Eun
core +1 more source
The Meckel syndrome- associated protein MKS1 functionally interacts with components of the BBSome and IFT complexes to mediate ciliary trafficking and hedgehog signaling. [PDF]
PLoS ONE, 2017 The importance of primary cilia in human health is underscored by the link between ciliary dysfunction and a group of primarily recessive genetic disorders with overlapping clinical features, now known as ciliopathies.
Sarah C Goetz +4 more
doaj +1 more source
A pathway for Parkinson's Disease LRRK2 kinase to block primary cilia and Sonic hedgehog signaling in the brain [PDF]
, 2018 Parkinson’s disease-associated LRRK2 kinase phosphorylates multiple Rab GTPases, including Rab8A and Rab10. We show here that LRRK2 kinase interferes with primary cilia formation in cultured cells, human LRRK2 G2019S iPS cells and in the cortex of LRRK2 ...
Alessi, Dario R. +8 more
core +2 more sources