Results 121 to 130 of about 4,305 (234)

Insights into degradation and targeting of the photoreceptor channelrhodopsin‐1

Plant, Cell &Environment, Volume 47, Issue 11, Page 4188-4211, November 2024.
Abstract In Chlamydomonas, the directly light‐gated, plasma membrane‐localized cation channels channelrhodopsins ChR1 and ChR2 are the primary photoreceptors for phototaxis. Their targeting and abundance is essential for optimal movement responses. However, our knowledge how Chlamydomonas achieves this is still at its infancy.
Michaela Wolfram, Arne Greif, Olga Baidukova, Hildegard Voll, Sandra Tauber, Jana Lindacher, Peter Hegemann, Georg Kreimer   +7 more
wiley   +1 more source

Improving treatment of glioblastoma: new insights in targeting cancer stem cells effectively [PDF]

, 2015
Glioblastoma is the most common primary malignant brain tumour in the adult population. Despite multimodality treatment with surgery, radiotherapy and chemotherapy, outcomes are very poor, with less than 15% of patients alive after two years ...
Mannino, Mariella
core  

The serologically defined colon cancer antigen-3 (SDCCAG3) is involved in the regulation of ciliogenesis [PDF]

, 2016
A primary cilium is present on most eukaryotic cells and represents a specialized organelle dedicated to signal transduction and mechanosensing. Defects in cilia function are the cause for several human diseases called ciliopathies.
A Doyotte, A Jurczyk, A Knodler, A Robert, AM Waters, B Chih, B Fogelgren, BG Coon, BK Yoder, C Fisch, CE Larkins, CJ Westlake, CL Williams, D Huangfu, DC Barral, DN Wheatley, F Finetti, F Finetti, F Hildebrandt, FR Garcia-Gonzalo, FR Garcia-Gonzalo, GD Gupta, GJ Pazour, GJ Pazour, H Hoffmeister, H Ishikawa, H Qin, I Franco, IJ McGough, J Kim, JA Deane, JF Dishinger, JF Reiter, K Madhivanan, K Madhivanan, KF Lechtreck, KG Kozminski, KG Kozminski, M Tsujikawa, MA Andrade, MV Nachury, N Hagemann, N Neznanov, NV Bukoreshtliev, RG Anderson, S Fan, T Caspary, T Mochizuki, TT Yang, X Ye, Y Cai   +50 more
core   +1 more source

Interferon regulatory factor 4 modulates epigenetic silencing and cancer‐critical pathways in melanoma cells

Molecular Oncology, Volume 18, Issue 10, Page 2423-2448, October 2024.
In this study, we showed that high interferon regulatory factor 4 (IRF4) expression is linked to dependency in melanoma cells and mortality in patients. Transcriptomic analysis uncovered epigenetic silencing factors as a novel target category. IRF4 consequently controls the expression of tumour suppressor genes known to be silenced by these epigenetic ...
Ulduz Sobhiafshar, Betül Çakici, Erdem Yilmaz, Nalan Yildiz Ayhan, Laila Hedaya, Mustafa Can Ayhan, Cansu Yerinde, Yasemin Begüm Alankuş, H. Kübra Gürkaşlar, Elif Nur Firat‐Karalar, N. C. Tolga Emre   +10 more
wiley   +1 more source

MyGene2 automated match report: ARL13B

, 2016
MyGene2.org is free, public, searchable & browsable website. Families with rare genetic conditions, clinicians, and researchers families who are interested in sharing health and genetic information can create MyGene2 profiles and use these to connect with other families, clinicians, and researchers who may have or be studying the same condition. If
openaire   +1 more source

Mutations in Dnaaf1 and Lrrc48 Cause Hydrocephalus, Laterality Defects, and Sinusitis in Mice

G3: Genes, Genomes, Genetics, 2016
We have previously described a forward genetic screen in mice for abnormalities of brain development. Characterization of two hydrocephalus mutants by whole-exome sequencing after whole-genome SNP mapping revealed novel recessive mutations in Dnaaf1 and ...
Seungshin Ha, Anna M. Lindsay, Andrew E. Timms, David R. Beier   +3 more
doaj   +1 more source

Identification of potential biomarkers and candidate small molecule drugs in glioblastoma

Cancer Cell International, 2020
Background and aims Glioblastoma (GBM) is a common and aggressive primary brain tumor, and the prognosis for GBM patients remains poor. This study aimed to identify the key genes associated with the development of GBM and provide new diagnostic and ...
Wei-cheng Lu, Hui Xie, Ce Yuan, Jin-jiang Li, Zhao-yang Li, An-hua Wu   +5 more
doaj   +1 more source

NRF2-dependent gene expression promotes ciliogenesis and Hedgehog signaling [PDF]

, 2019
The transcription factor NRF2 is a master regulator of cellular antioxidant and detoxification responses, but it also regulates other processes such as autophagy and pluripotency.
Blanco, Ruth, Cuadrado, Antonio, García-Gonzalo, Francesc R., Lastres-Becke, Isabel, Martin-Morales, Raquel, Martín-Hurtado, Ana, Palacios-Blanco, Inés, Robledinos-Antón, Natalia   +7 more
core   +1 more source

KIAA0753 enhances osteoblast differentiation suppressed by diabetes

Journal of Cellular and Molecular Medicine, Volume 28, Issue 17, September 2024.
Abstract Diabetes‐related bone loss represents a significant complication that persistently jeopardizes the bone health of individuals with diabetes. Primary cilia proteins have been reported to play a vital role in regulating osteoblast differentiation in diabetes‐related bone loss.
Mengxue Li, Yongqin Wang, Xiangmei Wu, Quanmei Chen, Jianguo Huang, Huifang Zhu, Shengyong Yang, Jichun Wang, Le Tai Li, Xianjun Liu, Kang Fu, Fangzhou Song, Changdong Wang   +12 more
wiley   +1 more source

Cilia proteins are biomarkers of altered flow in the vasculature

JCI Insight, 2022
Cilia, microtubule-based organelles that project from the apical luminal surface of endothelial cells (ECs), are widely regarded as low-flow sensors. Previous reports suggest that upon high shear stress, cilia on the EC surface are lost, and more recent ...
Ankan Gupta, Karthikeyan Thirugnanam, Madhan Thamilarasan, Ashraf M. Mohieldin, Hadeel T. Zedan, Shubhangi Prabhudesai, Meghan R. Griffin, Andrew D. Spearman, Amy Pan, Sean P. Palecek, Huseyin C. Yalcin, Surya M. Nauli, Kevin R. Rarick, Rahima Zennadi, Ramani Ramchandran   +14 more
doaj   +1 more source