Results 131 to 140 of about 4,305 (234)

CSAP localizes to polyglutamylated microtubules and promotes proper cilia function and zebrafish development [PDF]

, 2012
The diverse populations of microtubule polymers in cells are functionally distinguished by different posttranslational modifications, including polyglutamylation.
Audebert S, Bobinnec Y, Borovina A, Boucher D, Bre MH, Chad G. Pearson, Cheeseman IM, Cheeseman IM, Chelsea B. Backer, Desai A, Eddé B, Essner JJ, Fouquet JP, Graeden E, Gutzman JH, Iain M. Cheeseman, Ikegami K, Janke C, Janke C, Janke C, Jennifer H. Gutzman, Kimmel CB, Kimura Y, Kline SL, Kramer-Zucker AG, Kubo T, Lacroix B, Pathak N, Pearson CG, Peterkin T, Plessmann U, Regnard C, Robu ME, Rogowski K, Shang Y, Soldner F, Stephen Doxsey, Sullivan-Brown J, Suryavanshi S, van Dijk J, Verhey KJ, Vorobjev IA, Weber K, Westerfield M, Wloga D, Wolff A   +45 more
core   +1 more source

κB‐Ras proteins are fast‐exchanging GTPases and function via nucleotide‐independent binding of Ral GTPase‐activating protein complexes

FEBS Letters, Volume 598, Issue 14, Page 1769-1782, July 2024.
Contrary to previous predictions, we provide evidence that the small GTPase κB‐Ras possesses intrinsic hydrolytic activity. However, low nucleotide affinity leads to fast nucleotide exchange and renders κB‐Ras constitutively GTP‐bound in cells. We characterize κB‐Ras mutations occurring in tumors and define that nucleotide binding supports protein ...
René Rasche, Lisa Helene Apken, Esther Michalke, Daniel Kümmel, Andrea Oeckinghaus   +4 more
wiley   +1 more source

Arl13b Interacts With Vangl2 to Regulate Cilia and Photoreceptor Outer Segment Length in Zebrafish

Investigative Opthalmology & Visual Science, 2016
Mutations in the gene ARL13B cause the classical form of Joubert syndrome, an autosomal recessive ciliopathy with variable degrees of retinal degeneration. As second-site modifier alleles can contribute to retinal pathology in ciliopathies, animal models provide a unique platform to test how genetic interactions modulate specific phenotypes.
Ping Song, Joseph Fogerty, Brian D. Perkins, Robert J. Gaivin, Lynn Dudinsky   +4 more
openaire   +3 more sources

Primary cilia modulate TLR4-mediated inflammatory responses in hippocampal neurons

Journal of Neuroinflammation, 2017
Background The primary cilium is an organelle that can act as a master regulator of cellular signaling. Despite the presence of primary cilia in hippocampal neurons, their function is not fully understood.
Hyunjung Baek, Hyo Jung Shin, Jwa-Jin Kim, Nara Shin, Sena Kim, Min-Hee Yi, Enji Zhang, Jinpyo Hong, Joon Won Kang, Yonghyun Kim, Cuk-Seong Kim, Dong Woon Kim   +11 more
doaj   +1 more source

Serotonin 5-HT6 receptors affect cognition in a mouse model of Alzheimer’s disease by regulating cilia function

Alzheimer’s Research & Therapy, 2017
Background Serotonin receptor 5-HT6 is involved in cognition and Alzheimer’s disease (AD) development. However, the mechanism of 5-HT6 in AD pathology is not clear.
Lili Hu, Bingjie Wang, Yan Zhang
doaj   +1 more source

A CEP104-CSPP1 Complex Is Required for Formation of Primary Cilia Competent in Hedgehog Signaling [PDF]

, 2019
CEP104 is an evolutionarily conserved centrosomal and ciliary tip protein. CEP104 loss-of-function mutations are reported in patients with Joubert syndrome, but their function in the etiology of ciliopathies is poorly understood.
Akhmanova, Anna, Celbiologie, Frikstad, Kari-Anne M, Geimer, Stefan, Gilani, Sania, Giles, Rachel H, Hughes, Frances, Letteboer, Stef J F, Molinari, Elisa, Patzke, Sebastian, Pedersen, Lotte B, Ramsbottom, Simon A, Roepman, Ronald, Sayer, John A, Schink, Kay O, Stokke, Trond, Sub Cell Biology, Thoresen, Marianne   +17 more
core   +1 more source

ARMC9 and TOGARAM1 define a Joubert syndrome-associated protein module that regulates axonemal post-translational modifications and cilium stability [PDF]

, 2019
Joubert syndrome (JBTS) is a recessive neurodevelopmental ciliopathy, characterized by a pathognomonic hindbrain malformation. All known JBTS-genes encode proteins involved in the structure or function of primary cilia, ubiquitous antenna-like organelles
Alkuraya, Fowzan S, Bachmann-Gagescu, Ruxandra, Bamshad, Michael J, Boldt, Karsten, Dempsey, Jennifer C, Doherty, Dan, Gesemann, Matthias, Gomez, Arianna, Grout, Megan E, Latour, Brooke L, Letteboer, Stef J F, Miller, Caitlin V, Morsy, Heba, Neuhauss, Stephan C F, Nickerson, Deborah A, Roepman, Ronald, Rusterholz, Tamara D S, Shaheen, Ranad, Ueffing, Marius, van Beersum, Sylvia E C, Van De Weghe, Julie C, van Reeuwijk, Jeroen   +21 more
core   +1 more source

Eml1 loss impairs apical progenitor spindle length and soma shape in the developing cerebral cortex [PDF]

, 2017
The ventricular zone (VZ) of the developing cerebral cortex is a pseudostratified epithelium that contains progenitors undergoing precisely regulated divisions at its most apical side, the ventricular lining (VL).
Arras, G, Bizzotto, S, Croquelois, A, Dingli, F, Ershov, D, Francis, F, Houdusse, A, Houllier, A, Loew, D, Minc, N, Richards, M, Uzquiano, A   +11 more
core   +4 more sources

Peribronchial Inflammatory Cell Assessment in COPD Lung Tissues

Journal of Cellular and Molecular Medicine, Volume 28, Issue 22, November 2024.
Maëva A. Devilliers, Lynda Saber Cherif, Laure M. G. Petit, Nathalie Lalun, Arnaud Bonnomet, Anne Durlach, Gonzague Delepine, Myriam Polette, Jeanne‐Marie Perotin, Gaëtan Deslée, Valérian Dormoy   +10 more
wiley   +1 more source

Loss of OCRL increases ciliary PI(4,5)P2 in Lowe oculocerebrorenal syndrome [PDF]

, 2017
Lowe syndrome is a rare X-linked disorder characterized by bilateral congenital cataracts and glaucoma, mental retardation, and proximal renal tubular dysfunction. Mutations in OCRL, an inositol polyphosphate 5-phosphatase that dephosphorylates PI(4,5)P2,
Alvarado, Jorge A., Hu, Yang, Luo, Na, Prosseda, Philipp P., Sun, Yang, Wang, Biao   +5 more
core   +1 more source