Results 211 to 220 of about 4,305 (234)

ARL13B promotes angiogenesis and glioma growth by activating VEGFA-VEGFR2 signaling

Neuro-Oncology, 2022
Abstract Background Tumor angiogenesis is essential for solid tumor progression, invasion and metastasis. The aim of this study was to identify potential signaling pathways involved in tumor angiogenesis.
Limin Chen, Xinsheng Xie, Tiantian Wang, Linlin Xu, Zhenyu Zhai, Haibin Wu, Libin Deng, Quqin Lu, Zhengjun Chen, Xiao Yang, Hua Lu, Ye-Guang Chen, Shiwen Luo   +12 more
semanticscholar   +5 more sources

Rab8 and TNPO1 are ciliary transport adaptors for GTPase Arl13b by interacting with its RVEP motif containing ciliary targeting sequence [PDF]

Journal of Biological Chemistry, 2023
Divyanshu Mahajan
exaly   +3 more sources

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TULP3 is required for localization of membrane-associated proteins ARL13B and INPP5E to primary cilia

Biochemical and Biophysical Research Communications, 2019
The primary cilia are known as biosensors that transduce signals through the ciliary membrane proteins in vertebrate cells. The ciliary membrane contains transmembrane proteins and membrane-associated proteins. Tubby-like protein 3 (TULP3), a member of the tubby family, has been shown to interact with the intraflagellar transport-A complex (IFT-A) and ...
Takeshi Yoshimura, Yinshengzhuoma Wang, Taiichi Katayama, Genki Amano, Sho Shikada, Ko Miyoshi, Sarina Han   +6 more
exaly   +5 more sources

Active Transport and Diffusion Barriers Restrict Joubert Syndrome-Associated ARL13B/ARL-13 to an Inv-like Ciliary Membrane Subdomain [PDF]

PLoS Genetics, 2013
Cilia are microtubule-based cell appendages, serving motility, chemo-/mechano-/photo- sensation, and developmental signaling functions. Cilia are comprised of distinct structural and functional subregions including the basal body, transition zone (TZ ...
Sebiha Cevik, Erwin Van Wijk, Karsten Boldt   +2 more
exaly   +4 more sources

Arl13b promotes the proliferation, migration, osteogenesis, and mechanosensation of osteoblasts

Tissue and Cell, 2023
Primary cilia are microtubule-based organelles presenting on the surface of most postmitotic mammalian cells. As being signaling hubs and sensory organelles, primary cilia can respond to mechanical and chemical stimuli from the extracellular environment.
Tingting, Lin, Yao, Sun
openaire   +3 more sources

Axoneme polyglutamylation regulated by Joubert syndrome protein ARL13B controls ciliary targeting of signaling molecules

Nature Communications, 2018
The small GTPase ARL13B is mutated in the human ciliopathy Joubert syndrome. Here the authors show that ARL13B and the RAB11 effector FIP5 promote import of tubulin glutamylase into cilia and as such axoneme polyglutamylation, which is demonstrated to be
Jian Zhao, Kun Ling, Jinghua Hu
exaly   +3 more sources

Arl13b controls basal cell stemness properties and Hedgehog signaling in the mouse epididymis

Cellular and Molecular Life Sciences, 2022
Epithelial cells orchestrate a series of intercellular signaling events in response to tissue damage. While the epididymis is composed of a pseudostratified epithelium that controls the acquisition of male fertility, the maintenance of its integrity in the context of tissue damage or inflammation remains largely unknown.
Laura Girardet, Daniel G. Cyr, Clémence Belleannée   +2 more
openaire   +4 more sources

Novel compound heterozygous variants in ARL13B lead to Joubert syndrome

Journal of Cellular Physiology
AbstractJoubert syndrome (JBTS) is a systematic developmental disorder mainly characterized by a pathognomonic mid‐hindbrain malformation. All known JBTS‐associated genes encode proteins involved in the function of antenna‐like cellular organelle, primary cilium, which plays essential roles in cellular signal transduction and development.
Zaisheng Lin, Yue Shen, Yan Li, Chao Lu, Ying Zhu, Ruida He, Zongfu Cao, Zhe Yin, Huafang Gao, Bin Guo, Xu Ma, Muqing Cao, Minna Luo   +12 more
openaire   +3 more sources