Results 221 to 230 of about 4,305 (234)

Domain architecture of the atypical Arf-family GTPase Arl13b involved in cilia formation

Biochemical and Biophysical Research Communications, 2008
Arl13b is an atypical Arf/Arl-family GTPase consisting of an extending large C-terminal region (C domain) and Arf-homologous GTP-binding motifs in the N terminus (N domain). Although Arl13b appears to be involved in cilia formation, its precise function and roles of the domains remain unknown.
Tetsuo Kobayashi
exaly   +4 more sources

Ciliary Exclusion of ARL13B or Loss of Its GEF Activity for ARL3 Suppresses Polycystic Kidney Disease in Mice

Journal of the American Society of Nephrology, 2023
patient
Robert E. Van Sciver, Tamara Caspary
semanticscholar   +1 more source

ARL13B, a Joubert Syndrome-Associated Protein, Is Critical for Retinogenesis and Elaboration of Mouse Photoreceptor Outer Segments

Journal of Neuroscience, 2019
Mutations in the Joubert syndrome-associated small GTPase ARL13B are linked to photoreceptor impairment and vision loss. To determine the role of ARL13B in the development, function, and maintenance of ciliated photoreceptors, we generated a pan-retina ...
Abigail R Moye, Ezequiel M Salido, Andrew F X Goldberg   +2 more
exaly   +2 more sources

Ciliary ARL13B Is a Major Driver of Kidney Cystogenesis

Journal of the American Society of Nephrology, 2022
. Background: Childhood-onset chronic kidney disease (CKD) is a progressive condition with major impact on life expectancy and quality. We evaluated the usefulness of the kidney tubular cell stress marker urinary Dickkopf-3 (uDKK3) in determining the ...
Robert E. Van Sciver, Eduardo Gigante, Tamara Caspary   +2 more
semanticscholar   +1 more source

A novel Cre‐inducible knock‐in ARL13B‐tRFP fusion cilium reporter

genesis, 2017
SummaryCilia play a major role in the regulation of numerous signaling pathways and are essential for embryonic development. Mutations in genes affecting ciliary function can cause a variety of diseases in humans summarized as ciliopathies. To facilitate the detection and visualization of cilia in a temporal and spatial manner in mouse tissues, we ...
Felizitas Schmitz, Ingo Burtscher, Michael Stauber, Achim Gossler, Heiko Lickert   +4 more
openaire   +2 more sources

ARL13B Negatively Regulates Kidney Cysts from Within Cilia

Journal of the American Society of Nephrology, 2021
Background: We published that there is a decrease in autophagy proteins in Pkd1 RC/RC mouse kidneys. Our study aimed to determine the mechanistic role of suppressed autophagy in causing cyst growth using pharmacological and genetic autophagy inhibition ...
Robert E. Van Sciver, Eduardo Gigante, Tamara Caspary   +2 more
semanticscholar   +1 more source

Interactions Between TULP3 and ARL13B in Lipidated Protein Transport to Cilia and Regulation of Renal Cystogenesis

Journal of the American Society of Nephrology, 2021
Background: Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disease worldwide. Studies such as the TEMPO 3:4 and 4:4 have demonstrated tolvaptan’s (vasopressin V2 receptor antagonist) effectiveness in slowing the ...
Saikat Mukhopadhyay, Vivek R. Palicharla, S. Hwang   +2 more
semanticscholar   +1 more source

Volumetric Imaging and Analysis of Primary Cilia in Musculoskeletal Tissue using the ARL13B-CENTRIN-2 Mouse Model.

Journal of Visualized Experiments
The primary cilium is a non-motile, solitary organelle assembled by most cell types. It is essential to the development and homeostasis of the skeleton and in coordinating cell responses to biochemical and mechanical cues from their surrounding ...
Théana Johnson, Swati Midha, Angus Wann
semanticscholar   +1 more source

Induction of IMPDH-Based Cytoophidia by a Probable IMP-Dependent ARL13B-IMPDH Interaction.

Biochemistry. Biokhimiia
N. Alijani, Razieh Yazdanparast
semanticscholar   +1 more source

ARL13B promotes angiogenesis and glioma growth by activating VEGFA-VEGFR2 signaling

Neuro-Oncology, 2023
Xiao Yang
exaly