Results 71 to 80 of about 2,827 (178)

Arl13b regulates ciliogenesis and the dynamic localization of Shh signaling proteins

Molecular Biology of the Cell, 2011
Arl13b, a ciliary protein within the ADP-ribosylation factor family and Ras superfamily of GTPases, is required for ciliary structure but has poorly defined ciliary functions. In this paper, we further characterize the role of Arl13b in cilia by examining mutant cilia in vitro and determining the localization and dynamics of Arl13b within the cilium ...
Larkins, Christine E., Aviles, Gladys D. Gonzalez, East, Michael P., Kahn, Richard A., Caspary, Tamara   +4 more
openaire   +2 more sources

Ciliary phenotyping in renal epithelial cells in a cranioectodermal dysplasia patient with WDR35 variants

Frontiers in Molecular Biosciences, 2023
Background: Cranioectodermal dysplasia (CED) is a skeletal autosomal recessive ciliopathy. The characteristic clinical features of CED are facial dysmorphisms, short limbs, narrow thorax, brachydactyly, ectodermal abnormalities, and renal insufficiency ...
Joanna Walczak-Sztulpa, Anna Wawrocka, Łukasz Kuszel, Paulina Pietras, Marta Leśniczak-Staszak, Mirosław Andrusiewicz, Maciej R. Krawczyński, Anna Latos-Bieleńska, Marta Pawlak, Ryszard Grenda, Anna Materna-Kiryluk, Machteld M. Oud, Machteld M. Oud, Witold Szaflarski   +13 more
doaj   +1 more source

Centrosome-kinase fusions promote oncogenic signaling and disrupt centrosome function in myeloproliferative neoplasms. [PDF]

PLoS ONE, 2014
Chromosomal translocations observed in myeloproliferative neoplasms (MPNs) frequently fuse genes that encode centrosome proteins and tyrosine kinases. This causes constitutive activation of the kinase resulting in aberrant, proliferative signaling.
Joanna Y Lee, Wan-Jen Hong, Ravindra Majeti, Tim Stearns   +3 more
doaj   +1 more source

Loss of primary cilia promotes EphA2‐mediated endothelial‐to‐mesenchymal transition in the ovarian tumor microenvironment

Molecular Oncology, Volume 19, Issue 10, Page 2951-2966, October 2025.
Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho, Yubin Hah, Eunsik Yun, Hye In Ka, Aram Lee, Sora Han, Dawn Lee, Sung Wook Kim, Jong Hoon Park, Byung Su Kwon, Young Yang, Jongmin Kim   +11 more
wiley   +1 more source

Aurora‐A Promotes Cell‐Cycle Progression From Quiescence Through Primary Cilia Disassembly

Cancer Science, Volume 116, Issue 10, Page 2763-2773, October 2025.
Our findings demonstrate that AurA facilitates cell cycle reentry by promoting primary cilia disassembly. Utilizing an inducible degron system, we showed that AurA depletion delays the G0/G1 transition, a defect rescued by forced deciliation. These results underscore AurA's role beyond mitosis and reinforce its potential as a therapeutic target in ...
Atsushi Kohso, Hironori Inaba, Masato T. Kanemaki, Esteban C. Gabazza, Hidemi Toyoda, Masahiro Hirayama, Hidemasa Goto   +6 more
wiley   +1 more source

Conditional knockout mice for the distal appendage protein CEP164 reveal its essential roles in airway multiciliated cell differentiation. [PDF]

PLoS Genetics, 2017
Multiciliated cells of the airways, brain ventricles, and female reproductive tract provide the motive force for mucociliary clearance, cerebrospinal fluid circulation, and ovum transport.
Saul S Siller, Himanshu Sharma, Shuai Li, June Yang, Yong Zhang, Michael J Holtzman, Wipawee Winuthayanon, Holly Colognato, Bernadette C Holdener, Feng-Qian Li, Ken-Ichi Takemaru   +10 more
doaj   +1 more source

Fundamental Neurochemistry Review: Sphingolipids and Ceramides in Brain Development

Journal of Neurochemistry, Volume 169, Issue 10, October 2025.
Ceramides and sphingolipids in brain development and cell compartments. Ceramides and sphingolipids are known to influence multiple steps of brain development, including the formation of the neural tube, neural stem cell polarity and proliferation at the ventricular boundary, neuronal migration—for example, whilst migrating on radial glial processes ...
Kaviya Chinnappa, Fiona Ballorin, Fiona Francis   +2 more
wiley   +1 more source

Prostaglandin E2 and Progesterone Receptor Coordinately Regulate Primary Cilia for Proper Decidualization

The FASEB Journal, Volume 39, Issue 15, 15 August 2025.
Prostaglandin E2 (PGE2) activates the PKA‐CREB1 pathway to promote primary ciliogenesis and upregulates progesterone receptor (PGR) expression in endometrial stromal cells. Progesterone binds to PGR, enhancing the elongation of primary cilia. These processes drive the differentiation of stromal cells into decidual stromal cells, initiating and ...
Chih‐Jhen Lee, Yung‐Chieh Tsai, Ting‐Yu Chen, Yu‐Ying Chao, Ruei‐Ci Lin, Hui‐Ling Tsai, Jen‐Yu Wen, Tang K. Tang, Pei‐Yin Tsai, Pao‐Lin Kuo, Chia‐Yih Wang   +10 more
wiley   +1 more source

Post‐Translational Modifications in Cilia and Ciliopathies

Advanced Science, Volume 12, Issue 31, August 21, 2025.
This review synthesizes current understanding of post‐translational modifications (PTMs) in ciliary proteins and emphasizes their roles in ciliary formation, homeostasis, and signaling. This review also discusses the implication of PTM dysregulation in ciliopathies and explores therapeutic strategies targeting PTM‐modifying enzymes.
Jie Ran, Jun Zhou
wiley   +1 more source

Aurora kinase A inhibition plus Tumor Treating Fields suppress glioma cell proliferation in a cilium-independent manner

Translational Oncology
Tumor Treating Fields (TTFields) extend the survival of glioblastoma (GBM) patients by interfering with a broad range of tumor cellular processes. Among these, TTFields disrupt primary cilia stability on GBM cells.
Jia Tian, Julianne C. Mallinger, Ping Shi, Dahao Ling, Loic P. Deleyrolle, Min Lin, Habibeh Khoshbouei, Matthew R. Sarkisian   +7 more
doaj   +1 more source