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Pharmacogenetics of Aromatase Inhibitors
Pharmacogenomics, 2012Aromatase inhibitors (AIs) are an important class of endocrine drugs used in the treatment of early and advanced breast cancer in postmenopausal women. A number of studies have taken candidate approaches to assess the role of variants in genes encoding enzymes important in AI metabolism, notably CYP19A1 (aromatase), in AI response.
Hadfield, Kristen D., Newman, William G.
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Journal de la Societe de biologie, 2002
The cytochrome P450 aromatase (P450arom) is the terminal enzyme involved in the irreversible transformation of androgens into estrogens. The P450arom plays a role in development, reproduction, sexual differentiation and behaviour, but also in bone and lipid metabolisms, brain functions and diseases such as breast and testicular tumors.
Carreau, Serge +3 more
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The cytochrome P450 aromatase (P450arom) is the terminal enzyme involved in the irreversible transformation of androgens into estrogens. The P450arom plays a role in development, reproduction, sexual differentiation and behaviour, but also in bone and lipid metabolisms, brain functions and diseases such as breast and testicular tumors.
Carreau, Serge +3 more
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Aromatase inhibitors—Socioeconomical issues
The Journal of Steroid Biochemistry and Molecular Biology, 2005Novel, third-generation aromatase inhibitors are currently implemented for treatment of postmenopausal breast cancer in the metastatic and adjuvant setting and, potentially, for breast cancer prevention. Introduction of novel therapeutic strategies to large patient groups may add significant costs to health care budgets, forcing institutions to focus ...
Per E, Lønning, Jürgen, Geisler
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Aromatase Overexpression: Is Aromatase an Oncogene
2001To directly test the role of aromatase overexpression in tumorigenesis, we have developed a transgenic mouse model and demonstrated for the first time that increased tissue estrogens due to the overexpression of aromatase in mammary glands leads to the induction of various preneoplastic and neoplastic changes that are similar to early breast cancer ...
Rajeshwar Rao Tekmal +2 more
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Bulletin du cancer, 1999
Aromatase inhibitors used in breast cancer, are drugs that inhibit the transformation of androstenedione and testosterone, respectively in estradiol and estrone. Two classes have been described: steroidal inhibitors which act competitively and irreversibly and non steroidal inhibitors which block the P 450 cytochrome. The first one is aminoglutethimide
M L, Feutrie, J, Bonneterre
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Aromatase inhibitors used in breast cancer, are drugs that inhibit the transformation of androstenedione and testosterone, respectively in estradiol and estrone. Two classes have been described: steroidal inhibitors which act competitively and irreversibly and non steroidal inhibitors which block the P 450 cytochrome. The first one is aminoglutethimide
M L, Feutrie, J, Bonneterre
openaire +1 more source
Management of Growth Disorders in Puberty: GH, GnRHa, and Aromatase Inhibitors: A Clinical Review
Endocrine Reviews, 2023Nelly Mauras, Verónica Mericq
exaly