Results 1 to 10 of about 95 (70)

Aromatase deficiency in a tall man: Case report of two novel mutations and review of literature

Bone Reports, 2022
Aromatase (CYP19A1) is the only enzyme known to catalyse the conversion of androgen to estrogen. Aromatase deficiency occurs due to mutation in CYP19A1gene which has an autosomal recessive inheritance pattern.
Pankaj Singhania, Debasish Dash, Abhranil Dhar, Pritam Biswas, Piyas Gargari, Rana Bhattacharjee, Subhankar Chowdhury, Dipanjana Datta, Emili Banerjee   +8 more
doaj   +1 more source

Development and Characterization of Inducible Astrocyte-Specific Aromatase Knockout Mice

Biology, 2023
17β-estradiol (E2) is produced in the brain as a neurosteroid, in addition to being an endocrine signal in the periphery. The current animal models for studying brain-derived E2 include global and conditional non-inducible knockout mouse models.
Jing Wang, Uday P. Pratap, Yujiao Lu, Gangadhara R. Sareddy, Rajeshwar R. Tekmal, Ratna K. Vadlamudi, Darrell W. Brann   +6 more
doaj   +1 more source

Changes in the serum levels of estradiol and in the expression of estrogen receptor alpha in an experimental model of osteoporosis [PDF]

Archives of the Balkan Medical Union, 2022
Introduction. The decrease in serum estrogens concentration at menopause disrupts the metabolic balance and leads to visceral obesity, which causes an increase in serum estradiol levels, through aromatase activity.
Armine V. GRIGORYAN, Alexander B. BLAZHEV, Tatyana M. BETOVA, Aneliya A. DIMITROVA   +3 more
doaj   +1 more source

A novel compound heterozygous variant in CYP19A1 resulting in aromatase deficiency with normal ovarian tissue

The Turkish Journal of Pediatrics, 2020
Background. Aromatase deficiency leading to virilization in mother and female fetuses during pregnancy is a rare disease. It is characterized by impaired estrogen production, increased gonadotropins, and ovarian cysts. Case.
Sezer Acar, Ece Böber, Mustafa Olguner, Erdener Özer, Ayhan Abacı, Bayram Özhan, Semra Gürsoy, Tufan Çankaya, Hüseyin Onay, Ahu Paketçi, İbrahim Mert Erbaş, Korcan Demir   +11 more
doaj   +1 more source

Aromatase Deficiency in Two Siblings with 46,XX Karyotype Raised as Different Genders: A Novel Mutation (p.R115X) in the CYP19A1 Gene

JCRPE, 2020
Aromatase deficiency rarely causes a 46,XX sexual differentiation disorder. The CYP19A1 gene encodes the aromatase enzyme which catalyses the conversion of androgens to oestrogens.
Samim Özen, Tahir Atik, Özlem Korkmaz, Hüseyin Onay, Damla Gökşen, Ferda Özkınay, Özgür Çoğulu, Şükran Darcan   +7 more
doaj   +1 more source

Should Skeletal Maturation Be Manipulated for Extra Height Gain?

Frontiers in Endocrinology, 2021
Skeletal maturation can be delayed by reducing the exposure to estrogens, either by halting pubertal development through administering a GnRH analogue (GnRHa), or by blocking the conversion of androgens to estrogens through an aromatase inhibitor (AI ...
Jan M. Wit
doaj   +1 more source

Developmental vitamin D deficiency increases foetal exposure to testosterone

Molecular Autism, 2020
Background Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders which are more common in males. The ‘prenatal sex steroid’ hypothesis links excessive sex-steroid exposure during foetal life with the behavioural differences observed ...
Asad Amanat Ali, Xiaoying Cui, Renata Aparecida Nedel Pertile, Xiang Li, Gregory Medley, Suzanne Adele Alexander, Andrew J. O. Whitehouse, John Joseph McGrath, Darryl Walter Eyles   +8 more
doaj   +1 more source

Aromatase-Inhibitor-Induced Musculoskeletal Inflammation Is Observed Independent of Oophorectomy in a Novel Mouse Model

Pharmaceuticals, 2022
Aromatase Inhibitors (AIs) block estrogen production and improve survival in patients with hormone-receptor-positive breast cancer. However, half of patients develop aromatase-inhibitor-induced arthralgia (AIIA), which is characterized by inflammation of
Nicholas A. Young, Jeffrey Hampton, Juhi Sharma, Kyle Jablonski, Courtney DeVries, Anna Bratasz, Lai-Chu Wu, Maryam Lustberg, Raquel Reinbolt, Wael N. Jarjour   +9 more
doaj   +1 more source

Aromatase expression and role of estrogens in male gonad : a review

Reproductive Biology and Endocrinology, 2003
The ability of the testis to convert irreversibly androgens into estrogens is related to the presence of a microsomal enzymatic complex named aromatase, which is composed of a specific glycoprotein, the cytochrome P450 aromatase (P450arom) and an ...
Denis-Galeraud Isabelle, Delalande Christelle, Lambard Sophie, Carreau Serge, Bilinska Barbara, Bourguiba Sonia   +5 more
doaj   +1 more source

Treatment of testosterone deficiency syndrome in obese men with type 2 diabetes

Репродуктивная эндокринология, 2022
Objective: to study the effect of testosterone replacement therapy and aromatase inhibitors on the state of androgen supply in men with type 2 diabetes mellitus (DM-2) with obesity. Materials and methods.
Y.V. Luchytskyi, H.A. Zubkova, V.M. Rybalchenko, V.Y. Luchytskyi, I.I. Skladanna   +4 more
doaj   +1 more source