Results 41 to 50 of about 438,768 (166)

Long-term follow-up of a female with congenital adrenal hyperplasia due to P450-oxidoreductase deficiency

Archives of Endocrinology and Metabolism, 2016
SUMMARY P450 oxidoreductase deficiency (PORD) is a variant of congenital adrenal hyperplasia that is caused by POR gene mutations. The POR gene encodes a flavor protein that transfers electrons from nicotinamide adenine dinucleotide phosphate (NADPH) to ...
Beatriz D. S. F. Bonamichi, Stella L. M. Santiago, Débora R. Bertola, Chong A. Kim, Nivaldo Alonso, Berenice B. Mendonca, Tania A. S. S. Bachega, Larissa G. Gomes   +7 more
doaj   +1 more source

Study of Aromatase-Catalyzed Metabolic Switching of 2,2-Dimethylandrostenedione : Synthesis of Possible Metabolites and Their Inhibitory Activities of Aromatase [PDF]

, 2004
Aromatase is a cytochrome P-450 enzyme responsible for the conversion of androgens to estrogens. 2,2-Dimethylandrostenedione (5) is one of the powerful inhibitors of the enzyme.
山田, 恵子, 伴田, 和香子, 長岡, 正男, Hannda, Wakako, ヤマダ, ケイコ, Nagaoka, Masao, ヌマザワ, ミツテル, Numazawa, Mituteru, ナガオカ, マサオ, 沼澤, 光輝, ハンダ, ワカコ, Yamada, Keiko   +11 more
core  

The Utilization and Impact of Aromatase Inhibitor Therapy in Men With Elevated Estradiol Levels on Testosterone Therapy

Sexual Medicine, 2021
: Introduction: Testosterone therapy (TTH) for testosterone deficiency (TD) may lead to elevated estradiol (E2) levels requiring management to avoid unnecessary adverse effects.
Nahid Punjani, MD, MPH, Helen Bernie, DO, Carolyn Salter, MD, Jose Flores, MD, Nicole Benfante, BS, John P. Mulhall, MD, MSc, FECSM, FACS   +5 more
doaj   +1 more source

Aromatase deficiency caused by a novel P450arom gene mutation: impact of absent estrogen production on serum gonadotropin concentration in a boy.

, 1999
We identified a new point mutation in the CYP19 gene responsible for aromatase (P450arom) deficiency in a 46,XY male infant with unremarkable clinical findings at birth.
Harada, N., Flück, Christa, Mullis, Primus-Eugen, Yoshimura, N., Bex, M., Deladoëy, Johnny   +5 more
core   +1 more source

Histological Characterization and Comparative Transcriptomic Analysis of Gonads During Early Sex Differentiation in the Northern Snakehead (Channa argus)

Animal Research and One Health, EarlyView.
This study delineates the early sex differentiation timeline in the northern snakehead (Channa argus). These findings provide a foundation for future sex‐control breeding in this economically important species. ABSTRACT The northern snakehead (Channa argus) is an economically important aquaculture species in China.
Chaonan Sun, Donglei Sun, Haishen Wen, Xin Qi, Chao Li, Xiaoyan Zhang, Yun Li   +6 more
wiley   +1 more source

Metabolic effects of aromatase inhibition [PDF]

, 2015
Aromatase, a member of the cytochrome P450 superfamily, catalyses the conversion of androgens to estrogens; specifically, testosterone to estradiol and androstenedione to estrone. Aromatase is widely expressed across a range of tissues and deleterious
Gibb, Fraser Wilson
core   +3 more sources

Building families—Implementing balanced sexual and reproductive health

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract One of the main initiatives of the World Health Organization (WHO) is the promotion of Sexual and Reproductive Health (SRH). Sexuality, infertility, and contraception are three interconnected pillars of SRH, each essential for achieving global equity in family planning and family building.
Peter Y. Liu, Edgar Mocanu, Linda Giudice, Marcos Horton, Meletios P. Nigdelis, Antti Perheentupa, Andrea Sansone, Giovanni Corona, Luca Gianaroli, Dimitrios G. Goulis   +9 more
wiley   +2 more sources

Follicle Stimulating Hormone in Cattle Breeding: Fundamentals, Innovations, and Scope

Animal Research and One Health, EarlyView.
FSH is crucial in cattle reproduction, with exogenous administration enhancing breeding and embryo production. Recombinant FSH offers advantages over pituitary‐extracted variants, including fewer injections, reduced stress, and safer production. These innovations improve breeding efficiency, optimize reproductive outcomes, and contribute to sustainable
Muhammad Shahzad, Hubdar Ali Kolachi, Jesse Oluwaseun Ayantoye, Xiaomeng Zhang, Muhammad Usman Mehmood, Rajilan Hilali Shanga, Pengcheng Wan, Xueming Zhao   +7 more
wiley   +1 more source

Endocrinological aspects of dietary habits

Czech Journal of Food Sciences, 2004
Dietary habits reflect both the recent economic possibilities and the cultural history of individual human populations. They may influence endocrine systems and thus affect the health of the respective populations in several manners: (1) People consuming
O. Lapčík
doaj   +1 more source

Use of Clotrimazole in Finfish Aquaculture: Mechanistic Insights, Limitations, and Future Directions for Antifungal Therapy

Animal Research and One Health, EarlyView.
This review critically evaluates clotrimazole as a potential antifungal for finfish aquaculture, highlighting strong mechanistic and in vitro efficacy against aquatic mycoses alongside major gaps in in vivo evidence, toxicokinetics, residue safety, and environmental risk, outlining priorities for responsible therapeutic development and regulatory ...
Arya Sen, Debashri Mondal, Thangapalam Jawahar Abraham   +2 more
wiley   +1 more source