Results 21 to 30 of about 9,699 (146)

Aromatase expression and role of estrogens in male gonad : a review

Reproductive Biology and Endocrinology, 2003
The ability of the testis to convert irreversibly androgens into estrogens is related to the presence of a microsomal enzymatic complex named aromatase, which is composed of a specific glycoprotein, the cytochrome P450 aromatase (P450arom) and an ...
Denis-Galeraud Isabelle, Delalande Christelle, Lambard Sophie, Carreau Serge, Bilinska Barbara, Bourguiba Sonia   +5 more
doaj   +1 more source

Inhibition of Phosphodiesterase 5 Promotes the Aromatase-Mediated Estrogen Biosynthesis in Osteoblastic Cells by Activation of cGMP/PKG/SHP2 Pathway

Frontiers in Endocrinology, 2021
Mechanical stimulation induces bone growth and remodeling by the secondary messenger, cyclic guanosine 3’, 5’-monophosphate (cGMP), in osteoblasts. However, the role of cGMP in the regulation of estrogen biosynthesis, whose deficiency is a major cause of
Wisanee Wisanwattana, Wisanee Wisanwattana, Kanjana Wongkrajang, Dong-yi Cao, Dong-yi Cao, Xiao-ke Shi, Xiao-ke Shi, Zhong-hui Zhang, Zong-yuan Zhou, Zong-yuan Zhou, Fu Li, Qing-gang Mei, Chun Wang, Apichart Suksamrarn, Guo-lin Zhang, Fei Wang   +15 more
doaj   +1 more source

Study of Sex Differences in Duloxetine Efficacy for Depression in Transgenic Mouse Models

Frontiers in Cellular Neuroscience, 2017
Clinical evidences show sex differences in risk of developing depressive disorders as well as effect of antidepressants in depression treatment. However, whether such a sex-dependent risk of depression and efficacy of antidepressants is dependent on ...
Yong Xu, Lei Ma, Wei Jiang, Yuhong Li, Yuhong Li, Gang Wang, Rena Li, Rena Li, Rena Li   +8 more
doaj   +1 more source

Effect of Aromatase Inhibitor ,Sage And Flaxseed on Spermatogenesis In Rat [PDF]

مجلة التربية والعلم, 2020
The study was designed to investigate estrogen effect on testis, accessory sex glands  and sex hormones in male rats from weaning age at 21 days by using aromatase inhibitor letrozole ( 1 mg ̷ kg b. w.
Heba jasem, Fadwa tawfeek
doaj   +1 more source

Successful treatment of low-grade endometrial cancer in premenopausal women with an aromatase inhibitor after failure with oral or intrauterine progesterone

Gynecologic Oncology Reports, 2017
Introduction: Young women with endometrial intraepithelial hyperplasia or low-grade endometrial carcinoma are potential candidates for conservative fertility sparing therapy utilizing progesterone rather than hysterectomy.
Alli Straubhar, Andrew P. Soisson, Mark Dodson, Elise Simons   +3 more
doaj   +1 more source

Manejo farmacológico da baixa estatura: o papel dos inibidores da aromatase Pharmacological management of children with short stature: the role of aromatase inhibitors

Jornal de Pediatria, 2007
OBJETIVO: Revisão sobre o uso de inibidores de aromatase, uma nova modalidade terapêutica em pacientes com baixa estatura, numa tentativa de evitar o avanço rápido da idade óssea, dependente da produção estrogênica, mesmo no sexo masculino.
Durval Damiani, Daniel Damiani
doaj   +1 more source

Nuclear Mechanisms Involved in Endocrine Resistance

Frontiers in Oncology, 2021
Endocrine therapy is a standard treatment offered to patients with ERα (estrogen receptor α)-positive breast cancer. In endocrine therapy, ERα is either directly targeted by anti-estrogens or indirectly by aromatase inhibitors which cause estrogen ...
Jürgen Dittmer
doaj   +1 more source

Regulation of P450 oxidoreductase by gonadotropins in rat ovary and its effect on estrogen production

Reproductive Biology and Endocrinology, 2008
Background P450 oxidoreductase (POR) catalyzes electron transfer to microsomal P450 enzymes. Its deficiency causes Antley-Bixler syndrome (ABS), and about half the patients with ABS have ambiguous genitalia and/or impaired steroidogenesis.
Uesaka Miki, Kangawa Kenji, Kokame Koichi, Mizutani Tetsuya, Yazawa Takashi, Inaoka Yoshihiko, Umezawa Akihiro, Miyamoto Kaoru   +7 more
doaj   +1 more source

Normogonadotropic ovarian insufficiency in adolescence (review of literature and clinical case)

Mìžnarodnij Endokrinologìčnij Žurnal, 2017
The objective of the review. Analysis of literature data related to the normogonadotropic ovarian insufficiency. Basic statements. The article presents a literature review and clinical case of normogonadotropic ovarian insufficiency in girls aged 16 ...
T.V. Sorokman, S.V. Sokolnyk, P.M. Moldovan, N.O. Popeliuk   +3 more
doaj   +1 more source

Diagnosis and management of non-CAH 46,XX disorders/differences in sex development

Frontiers in Endocrinology
Prenatal-onset androgen excess leads to abnormal sexual development in 46,XX individuals. This androgen excess can be caused endogenously by the adrenals or gonads or by exposure to exogenous androgens.
Zehra Yavas Abalı, Tulay Guran
doaj   +1 more source