Results 21 to 30 of about 438,768 (166)

Nuclear Mechanisms Involved in Endocrine Resistance

Frontiers in Oncology, 2021
Endocrine therapy is a standard treatment offered to patients with ERα (estrogen receptor α)-positive breast cancer. In endocrine therapy, ERα is either directly targeted by anti-estrogens or indirectly by aromatase inhibitors which cause estrogen ...
Jürgen Dittmer
doaj   +1 more source

Cobalt‐Catalyzed C─N Bond Formation via Metal‐Hydride Hydrogen Atom Transfer (MHAT)

Angewandte Chemie, EarlyView.
Cobalt‐catalyzed metal‐hydride hydrogen atom transfer (Co‐MHAT) converts simple alkenes into C─N bonds under mild, near‐neutral conditions. A shared Co─H‐initiated radical/organocobalt intermediate is channeled into radical trapping, radical‐polar crossover, or radical ligand transfer, unifying hydroamination, hydroazidation, hydroamidation, and remote
Arman Khosravi, Ming‐Yu Ngai
wiley   +2 more sources

Regulation of P450 oxidoreductase by gonadotropins in rat ovary and its effect on estrogen production

Reproductive Biology and Endocrinology, 2008
Background P450 oxidoreductase (POR) catalyzes electron transfer to microsomal P450 enzymes. Its deficiency causes Antley-Bixler syndrome (ABS), and about half the patients with ABS have ambiguous genitalia and/or impaired steroidogenesis.
Uesaka Miki, Kangawa Kenji, Kokame Koichi, Mizutani Tetsuya, Yazawa Takashi, Inaoka Yoshihiko, Umezawa Akihiro, Miyamoto Kaoru   +7 more
doaj   +1 more source

Aromatase Deficiency due to a Novel Mutation in CYP19A1 Gene [PDF]

, 2018
Aromatase deficiency is a rare autosomal recessive genetic disorder with an unknown incidence. Aromatase converts androgens into estrogen in the gonadal and extra-gonadal tissues.
Onay, Huseyin, Demir, Vasfiye, Unal, Edip, Tas, Funda Feryal, Edip Ünal, Yildirim, Ruken, Haspolat, Yusuf Kenan, Ruken Yıldırım, Hüseyin Onay, Yusuf Kenan Haspolat, Funda Feryal Taş, Yıldırım, Ruken, Vasfiye Demir   +12 more
core   +1 more source

Human Aromatase Deficiency [PDF]

, 2018
Several molecular CYP19A1 gene alterations associated with cytochrome P450 aromatase (cP450arom) deficiency have been describedin both females and males.
Marino, Roxana Marcela, Belgorosky, Alicia, Saraco, Nora Isabel, Costanzo, Mariana, Guercio, Gabriela Viviana   +4 more
core   +1 more source

Aromatase Deficiency Confers Paradoxical Postischemic Cardioprotection

, 2011
The conventional view is that estrogen confers female cardioprotection. Estrogen synthesis depends on androgen availability, with aromatase regulating conversion of testosterone to estradiol. Extragonadal aromatase expression mediates estrogen production
Lea M. D. Delbridge, James R. Bell, Kimberley M. Mellor, Melissa E. Reichelt, Wendy T. K. Ip, Evan R. Simpson, Amanda C. Wollermann, Sarah J. Meachem   +7 more
core   +2 more sources

The cytochrome P450 aromatase lacking exon 5 is associated with a phenotype of nonclassic aromatase deficiency and is also present in normal human steroidogenic tissues [PDF]

, 2007
OBJECTIVE: The previously described c655G>A mutation of the human cytochrome P450 aromatase gene (P450aro, CYP19) results in aberrant splicing due to disruption of a donor splice site.
Guercio, Gabriela, Marino, Roxana, Pepe, Carolina M, Pandey, Amit V, Flück, Christa E, Belgorosky, Alicia, Vaiani, Elisa, Baquedano, Maria Sonia, Saraco, Nora I, Rivarola, Marco A   +9 more
core   +1 more source

Diagnosis and management of non-CAH 46,XX disorders/differences in sex development

Frontiers in Endocrinology
Prenatal-onset androgen excess leads to abnormal sexual development in 46,XX individuals. This androgen excess can be caused endogenously by the adrenals or gonads or by exposure to exogenous androgens.
Zehra Yavas Abalı, Tulay Guran
doaj   +1 more source

Normogonadotropic ovarian insufficiency in adolescence (review of literature and clinical case)

Mìžnarodnij Endokrinologìčnij Žurnal, 2017
The objective of the review. Analysis of literature data related to the normogonadotropic ovarian insufficiency. Basic statements. The article presents a literature review and clinical case of normogonadotropic ovarian insufficiency in girls aged 16 ...
T.V. Sorokman, S.V. Sokolnyk, P.M. Moldovan, N.O. Popeliuk   +3 more
doaj   +1 more source

A case of Aromatase deficiency due to a novel CYP19A1 mutation [PDF]

, 2014
BACKGROUND Aromatase deficiency is a rare, autosomal recessive disorder of which there are approximately twenty four case reports. The aromatase enzyme is crucial in the biosynthesis of oestrogens from androgens.
Jinghua Feng, Hamish S Scott, Gagliardi, L., Torpy, D., Scott, H., David J Torpy, Feng, J., Lucia Gagliardi   +7 more
core   +2 more sources