Results 11 to 20 of about 438,768 (166)

A Novel Homozygous CYP19A1 Gene Mutation: Aromatase Deficiency Mimicking Congenital Adrenal Hyperplasia in an Infant without Obvious Maternal Virilisation

JCRPE, 2019
Aromatase deficiency is a rare, autosomal recessive disorder in which affected patients fail to synthesize normal estrogen. Herein, we report a 46, XX patient born with virilised external genitalia.
Fatma Dursun, Serdar Ceylaner
doaj   +2 more sources

Cloning, sequencing and In situ localisation of guppy brain aromatase, cyp19b

Oestrogens are biosynthesised by cytochrome p450-aromatase (Cyp19). Brain oestrogens serve several important functions of which nerve protection, cell proliferation, nerve development and behaviour control are a few.
Hallgren, Stefan,, Kitambi, Satish Srinivas,   +1 more
core   +10 more sources

Long‐term prognosis is associated with residual disease after neoadjuvant systemic therapy but not with initial nodal status

BJS (British Journal of Surgery), EarlyView., 2020
This long‐term follow‐up study determined survival rates in a Swedish national cohort of 417 patients with breast cancer who all had neoadjuvant systemic therapy (NAST). Sentinel lymph node biopsy (SLNB) was performed before NAST in clinically node‐negative and after NAST in clinically node‐positive patients.
L. Zetterlund, F. Celebioglu, T. Hatschek, J. Frisell, J. de Boniface   +4 more
wiley   +1 more source

A non-synonymous coding change in the CYP19A1 gene Arg264Cys (rs700519) does not affect circulating estradiol, bone structure or fracture [PDF]

, 2011
Background The biosynthesis of estrogens from androgens is catalyzed by aromatase P450 enzyme, coded by the CYP19A1 gene on chromosome 15q21.2. Genetic variation within the CYP19A1 gene sequence has been shown to alter the function of the enzyme.
Mullin, B., Ingley Evan, Lewis, J., Evan Ingley, Wilson Scott G, McNab, Tegan, Jenny Z Wang, Wang, J., Wang, J.Z., Deogan, M.S., Prince, R.L., McNab Tegan J, Ben H Mullin, Chew Shelby, McNab, T.J., Chew, S., Wang Jenny Z, Mandeep S Deogan, Richard L Prince, Mullin Ben H, Scott G Wilson, Tegan J McNab, Lewis, J.R., Prince, R., Ingley, E., Prince Richard L, Deogan Mandeep S, Deogan, M., Wilson, S., Wilson, S.G., Mullin, B.H., Lewis Joshua R, Shelby Chew, Joshua R Lewis   +33 more
core   +2 more sources

Study of Sex Differences in Duloxetine Efficacy for Depression in Transgenic Mouse Models

Frontiers in Cellular Neuroscience, 2017
Clinical evidences show sex differences in risk of developing depressive disorders as well as effect of antidepressants in depression treatment. However, whether such a sex-dependent risk of depression and efficacy of antidepressants is dependent on ...
Yong Xu, Lei Ma, Wei Jiang, Yuhong Li, Yuhong Li, Gang Wang, Rena Li, Rena Li, Rena Li   +8 more
doaj   +1 more source

Inhibition of Phosphodiesterase 5 Promotes the Aromatase-Mediated Estrogen Biosynthesis in Osteoblastic Cells by Activation of cGMP/PKG/SHP2 Pathway

Frontiers in Endocrinology, 2021
Mechanical stimulation induces bone growth and remodeling by the secondary messenger, cyclic guanosine 3’, 5’-monophosphate (cGMP), in osteoblasts. However, the role of cGMP in the regulation of estrogen biosynthesis, whose deficiency is a major cause of
Wisanee Wisanwattana, Wisanee Wisanwattana, Kanjana Wongkrajang, Dong-yi Cao, Dong-yi Cao, Xiao-ke Shi, Xiao-ke Shi, Zhong-hui Zhang, Zong-yuan Zhou, Zong-yuan Zhou, Fu Li, Qing-gang Mei, Chun Wang, Apichart Suksamrarn, Guo-lin Zhang, Fei Wang   +15 more
doaj   +1 more source

Effect of Aromatase Inhibitor ,Sage And Flaxseed on Spermatogenesis In Rat [PDF]

مجلة التربية والعلم, 2020
The study was designed to investigate estrogen effect on testis, accessory sex glands  and sex hormones in male rats from weaning age at 21 days by using aromatase inhibitor letrozole ( 1 mg ̷ kg b. w.
Heba jasem, Fadwa tawfeek
doaj   +1 more source

Successful treatment of low-grade endometrial cancer in premenopausal women with an aromatase inhibitor after failure with oral or intrauterine progesterone

Gynecologic Oncology Reports, 2017
Introduction: Young women with endometrial intraepithelial hyperplasia or low-grade endometrial carcinoma are potential candidates for conservative fertility sparing therapy utilizing progesterone rather than hysterectomy.
Alli Straubhar, Andrew P. Soisson, Mark Dodson, Elise Simons   +3 more
doaj   +1 more source

Aromatase deficiency in hematopoietic cells improves glucose tolerance in male mice through skeletal muscle-specific effects.

PLoS ONE, 2020
Estrogens are important for maintaining metabolic health in males. However, the key sources of local estrogen production for regulating energy metabolism have not been fully defined.
Katya B Rubinow, Laura J den Hartigh, Leela Goodspeed, Shari Wang, Orhan K Oz   +4 more
doaj   +1 more source

Manejo farmacológico da baixa estatura: o papel dos inibidores da aromatase Pharmacological management of children with short stature: the role of aromatase inhibitors

Jornal de Pediatria, 2007
OBJETIVO: Revisão sobre o uso de inibidores de aromatase, uma nova modalidade terapêutica em pacientes com baixa estatura, numa tentativa de evitar o avanço rápido da idade óssea, dependente da produção estrogênica, mesmo no sexo masculino.
Durval Damiani, Daniel Damiani
doaj   +1 more source