Results 1 to 10 of about 49,677 (283)

CXCR7 controls competition for recruitment of β-arrestin 2 in cells expressing both CXCR4 and CXCR7. [PDF]

PLoS ONE, 2014
Chemokine CXCL12 promotes growth and metastasis of more than 20 different human cancers, as well as pathogenesis of other common diseases. CXCL12 binds two different receptors, CXCR4 and CXCR7, both of which recruit and signal through the cytosolic ...
Nathaniel L Coggins, Danielle Trakimas, S Laura Chang, Anna Ehrlich, Paramita Ray, Kathryn E Luker, Jennifer J Linderman, Gary D Luker   +7 more
doaj   +3 more sources

Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser [PDF]

Nature, 2015
G-protein-coupled receptors (GPCRs) signal primarily through G proteins or arrestins. Arrestin binding to GPCRs blocks G protein interaction and redirects signalling to numerous G-protein-independent pathways.
Yanyong Kang, X Edward Zhou, Yuanzheng He   +2 more
exaly   +3 more sources

A small molecule enhances arrestin-3 binding to the β2-adrenergic receptor [PDF]

Communications Chemistry
Excessive signaling by various GPCRs underlies a variety of human disorders. Suppression of GPCRs by “enhanced” arrestin mutants was proposed as therapy.
Han Kurt, Ali Akyol, Cagdas Devrim Son, Chen Zheng, Irene Gado, Massimiliano Meli, Erica Elisa Ferrandi, Ivan Bassanini, Francesca Vasile, Vsevolod V. Gurevich, Aylin Nebol, Esra Cagavi, Giulia Morra, Ozge Sensoy   +13 more
doaj   +2 more sources

Lipids modulate the dynamics of GPCR:β-arrestin interaction [PDF]

Nature Communications
β-arrestins are key molecular partners of G Protein-Coupled Receptors (GPCRs), triggering not only their desensitization but also intracellular signaling.
Antoniel A. S. Gomes, Michela Di Michele, Rita Ann Roessner, Marjorie Damian, Paulo M. Bisch, Nathalie Sibille, Maxime Louet, Jean-Louis Banères, Nicolas Floquet   +8 more
doaj   +2 more sources

Characterization of three vasopressin receptor 2 variants: an apparent polymorphism (V266A) and two loss-of-function mutations (R181C and M311V). [PDF]

, 2013
Arginine vasopressin (AVP) is released from the posterior pituitary and controls water homeostasis. AVP binding to vasopressin V2 receptors (V2Rs) located on kidney collecting duct epithelial cells triggers activation of Gs proteins, leading to increased
Armstrong, Stephen P, Ayoub, Mohammed Akli, Feldman, Brian J, Pfleger, Kevin DG, Seeber, Ruth M   +4 more
core   +14 more sources

Receptor-Arrestin Interactions: The GPCR Perspective

Biomolecules, 2021
Arrestins are a small family of four proteins in most vertebrates that bind hundreds of different G protein-coupled receptors (GPCRs). Arrestin binding to a GPCR has at least three functions: precluding further receptor coupling to G proteins ...
Mohammad Seyedabadi, Mehdi Gharghabi, Eugenia V. Gurevich, Vsevolod V. Gurevich   +3 more
doaj   +1 more source

ClickArr: a novel, high-throughput assay for evaluating β-arrestin isoform recruitment

Frontiers in Pharmacology, 2023
Background: Modern methods for quantifying signaling bias at G protein–coupled receptors (GPCRs) rely on using a single β-arrestin isoform. However, it is increasingly appreciated that the two β-arrestin isoforms have unique roles, requiring the ability ...
Alexander R. French, Alexander R. French, Yazan J. Meqbil, Yazan J. Meqbil, Richard M. van Rijn, Richard M. van Rijn, Richard M. van Rijn   +6 more
doaj   +1 more source

β-arrestin-1 and β-arrestin-2 Restrain MRGPRX2-Triggered Degranulation and ERK1/2 Activation in Human Skin Mast Cells

Frontiers in Allergy, 2022
As a novel receptor that efficiently elicits degranulation upon binding to one of its numerous ligands, MRGPRX2 has moved to the center of attention in mast cell (MC) research.
Zhao Wang, Zhao Wang, Zhao Wang, Zhuoran Li, Zhuoran Li, Gürkan Bal, Gürkan Bal, Kristin Franke, Kristin Franke, Torsten Zuberbier, Torsten Zuberbier, Magda Babina, Magda Babina   +12 more
doaj   +1 more source

β-Arrestin-dependent deactivation of mouse melanopsin. [PDF]

PLoS ONE, 2014
In mammals, the expression of the unusual visual pigment, melanopsin, is restricted to a small subset of intrinsically photosensitive retinal ganglion cells (ipRGCs), whose signaling regulate numerous non-visual functions including sleep, circadian ...
Evan G Cameron, Phyllis R Robinson
doaj   +1 more source

Exploration of beta-arrestin isoform signaling pathways in delta opioid receptor agonist-induced convulsions

Frontiers in Pharmacology, 2022
The δ-opioid receptor (δOR) has been considered as a therapeutic target in multiple neurological and neuropsychiatric disorders particularly as δOR agonists are deemed safer alternatives relative to the more abuse-liable µ-opioid receptor drugs. Clinical
Arryn T. Blaine, Arryn T. Blaine, Yiming Miao, Jinling Yuan, Sophia Palant, Rebecca J. Liu, Zhong-Yin Zhang, Zhong-Yin Zhang, Zhong-Yin Zhang, Richard. M. van Rijn, Richard. M. van Rijn, Richard. M. van Rijn, Richard. M. van Rijn   +12 more
doaj   +1 more source