Results 211 to 220 of about 46,183 (248)
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The molecular acrobatics of arrestin activation
Trends in Pharmacological Sciences, 2004Arrestin proteins play a key role in desensitizing G-protein-coupled receptors and re-directing their signaling to alternative pathways. The precise timing of arrestin binding to the receptor and its subsequent dissociation is ensured by its exquisite selectivity for the activated phosphorylated form of the receptor.
Vsevolod V, Gurevich +1 more
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Arrestin Regulation of Small GTPases
2013The regulation of small GTPases by arrestins is a relatively new way by which arrestin can exert influence over cell signalling cascades, hence, molecular interactions and specific binding partners are still being discovered. A pathway showcasing the regulation of GTPase activity by β-arrestin was first elucidated in 2001.
Ryan T, Cameron, George S, Baillie
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Arrestin-Dependent Localization of Phosphodiesterases
2013Many G-protein-coupled receptors trigger the synthesis of cAMP in order to transduce signals from the membrane into the cell cytoplasm. As stimulation of each receptor type results in a specific physiological outcome, compartmentalization of proteins that make, break, and are activated by cAMP underpin receptor-specific responses.
Miranda J, Willis, George S, Baillie
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Science's STKE, 2005
Herranz et al . report the identification of a fungal arrestin homolog and its role in pH signaling. PalF, a protein containing C-terminal and N-terminal arrestin domains, interacted with PalH, the 7 transmembrane receptor (7TMR) in two-hybrid assays and glutathione- S -transferase (GST) pull-
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Herranz et al . report the identification of a fungal arrestin homolog and its role in pH signaling. PalF, a protein containing C-terminal and N-terminal arrestin domains, interacted with PalH, the 7 transmembrane receptor (7TMR) in two-hybrid assays and glutathione- S -transferase (GST) pull-
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Characterization of arrestin expression and function
2002Publisher Summary Arrestins mediate the desensitization and trafficking of numerous G protein coupled receptors (GPCRs). Agonist-dependent phosphorylation of GPCRs by GPCR kinases (GRKs) promotes high-affinity binding of arrestins that in turn sterically inhibit G protein interaction with the agonist-activated GPCR. There are currently four mammalian
Stuart J, Mundell +2 more
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Membrane phosphoinositides regulate GPCR-β-arrestin complex assembly and dynamics
Cell, 2022John Janetzko, Brian K Kobilka
exaly
GPCR-mediated β-arrestin activation deconvoluted with single-molecule precision
Cell, 2022Wesley B Asher +2 more
exaly
The 2.8 A crystal structure of visual arrestin: a model for arrestin's regulation.
Cell, 1999G protein-coupled signaling is utilized by a wide variety of eukaryotes for communicating information from the extracellular environment. Signal termination is achieved by the action of the arrestins, which bind to activated, phosphorylated G protein-coupled receptors.
J A, Hirsch +3 more
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Plasma membrane preassociation drives β-arrestin coupling to receptors and activation
Cell, 2023Maria Makarova, Davide Calebiro
exaly