Results 211 to 220 of about 31,759 (252)
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Science, 2004
The G protein-coupled receptors (GPCRs) transduce signals elicited by many different factors, including hormones, neurotransmitters, and cytokines. Negative and positive regulation of signaling for a majority of GPCRs is controlled by receptor association with the cytoplasmic protein arrestin.
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The G protein-coupled receptors (GPCRs) transduce signals elicited by many different factors, including hormones, neurotransmitters, and cytokines. Negative and positive regulation of signaling for a majority of GPCRs is controlled by receptor association with the cytoplasmic protein arrestin.
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Dopamine receptor D4 internalization requires a beta-arrestin and a visual arrestin
Cellular Signalling, 2015The G-protein coupled receptor (GPCR) Dopamine Receptor D4 (DRD4) plays an essential role in cAMP regulation and gap junctional coupling in the photoreceptors, where DRD4 expression is under circadian control. Previous in vitro transfection studies of human DRD4 desensitization have reported that DRD4 is not internalized upon dopamine stimulation when ...
Janise D, Deming +5 more
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Biochemistry, 1999
The sulfhydryl groups of the three cysteines in bovine arrestin react with DTNB very slowly (over a period of several hours). In the presence of the synthetic phosphopeptide comprising the fully phosphorylated carboxyl-terminal 19 amino acids of bovine rhodopsin, the reactivity of one of the sulfhydryls was enhanced while that of another was greatly ...
J H, McDowell +6 more
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The sulfhydryl groups of the three cysteines in bovine arrestin react with DTNB very slowly (over a period of several hours). In the presence of the synthetic phosphopeptide comprising the fully phosphorylated carboxyl-terminal 19 amino acids of bovine rhodopsin, the reactivity of one of the sulfhydryls was enhanced while that of another was greatly ...
J H, McDowell +6 more
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Arrestin-substypes in insect antennae
Cellular Signalling, 1993Arrestin is supposed to be involved in uncoupling receptor-mediated second messenger cascades. Clones encoding proteins homologous to arrestin have been isolated from antennal cDNA libraries of Locusta migratoria and Heliothis virescens. Based on the size and several characteristic motifs, the two proteins are considered as members of different ...
K, Raming +3 more
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Permanently biased toward arrestins
Science Signaling, 2021The seven-transmembrane receptors D6R and C5aR2 are natural examples of β-arrestin–biased receptors.
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Science's STKE, 2005
Herranz et al . report the identification of a fungal arrestin homolog and its role in pH signaling. PalF, a protein containing C-terminal and N-terminal arrestin domains, interacted with PalH, the 7 transmembrane receptor (7TMR) in two-hybrid assays and glutathione- S -transferase (GST) pull-
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Herranz et al . report the identification of a fungal arrestin homolog and its role in pH signaling. PalF, a protein containing C-terminal and N-terminal arrestin domains, interacted with PalH, the 7 transmembrane receptor (7TMR) in two-hybrid assays and glutathione- S -transferase (GST) pull-
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Arrestins as rheostats of GPCR signalling
Nature Reviews Molecular Cell Biology, 2018G protein-coupled receptors (GPCRs) have a central role in a myriad of physiological functions and their dysregulation underlies some of the most prevalent human diseases. They control cell behaviour and cell fate by recruiting and activating intracellular molecules such as heterotrimeric G proteins and arrestins, both of which take active roles in ...
J Silvio, Gutkind, Evi, Kostenis
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Arrestin Regulation of Small GTPases
2013The regulation of small GTPases by arrestins is a relatively new way by which arrestin can exert influence over cell signalling cascades, hence, molecular interactions and specific binding partners are still being discovered. A pathway showcasing the regulation of GTPase activity by β-arrestin was first elucidated in 2001.
Ryan T, Cameron, George S, Baillie
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Characterization of arrestin expression and function
2002Publisher Summary Arrestins mediate the desensitization and trafficking of numerous G protein coupled receptors (GPCRs). Agonist-dependent phosphorylation of GPCRs by GPCR kinases (GRKs) promotes high-affinity binding of arrestins that in turn sterically inhibit G protein interaction with the agonist-activated GPCR. There are currently four mammalian
Stuart J, Mundell +2 more
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Membrane phosphoinositides regulate GPCR-β-arrestin complex assembly and dynamics
Cell, 2022Brian Kobilka, John Janetzko
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