Results 31 to 40 of about 49,677 (283)

Insulin Action under Arrestin [PDF]

Cell Metabolism, 2009
Insulin signaling is key to the etiology of metabolic syndrome. Recent work (Luan et al., 2009) uncovers a role for beta-arrestin, previously known to control GPCR desensitization, in insulin signaling. In mouse models, beta-arrestin-2 controls whole-body insulin action by regulating assembly of a complex containing insulin receptor, c-Src, and Akt.
Stöckli, Jacqueline, James, David E.
openaire   +2 more sources

DEER Analysis of GPCR Conformational Heterogeneity

Biomolecules, 2021
G protein-coupled receptors (GPCRs) represent a large class of transmembrane helical proteins which are involved in numerous physiological signaling pathways and therefore represent crucial pharmacological targets.
Matthias Elgeti, Wayne L. Hubbell
doaj   +1 more source

QR code model: a new possibility for GPCR phosphorylation recognition

Cell Communication and Signaling, 2022
G protein-coupled receptors (GPCRs) are the largest family of membrane proteins in the human body and are responsible for accurately transmitting extracellular information to cells. Arrestin is an important member of the GPCR signaling pathway.
Hao Chen, Suli Zhang, Xi Zhang, Huirong Liu   +3 more
doaj   +1 more source

Arrestin-Coding Genes Regulate Endocytosis, Sporulation, Pathogenicity, and Stress Resistance in Arthrobotrys oligospora

Frontiers in Cellular and Infection Microbiology, 2022
Arrestins are a family of scaffold proteins that play a crucial role in regulating numerous cellular processes, such as GPCR signaling. The Arthrobotrys oligospora arrestin family contains 12 members, which have highly conserved N-terminal and C-terminal
Liang Zhou, Liang Zhou, Mengfei Li, Mengfei Li, Peijie Cui, Peijie Cui, Mengqing Tian, Mengqing Tian, Ya Xu, Ya Xu, Xi Zheng, Xi Zheng, Keqin Zhang, Keqin Zhang, Guohong Li, Guohong Li, Xin Wang, Xin Wang   +17 more
doaj   +1 more source

Orexin-Corticotropin-Releasing Factor Receptor Heteromers in the Ventral Tegmental Area as Targets for Cocaine [PDF]

, 2015
Release of the neuropeptides corticotropin-releasing factor (CRF) and orexin-A in the ventral tegmental area (VTA) play an important role in stress-induced cocaine-seeking behavior.
Aguinaga, David, Cai, Ning-Sheng, Canela, Enric I, Casadó, Vicent, Cortés, Antonio, Ferré, Sergi, Hausch, Felix, Howell, Lesley A., Lluís, Carme, Mallol, Josefa, McCormick, Peter J., McDowell, Kimberly, Moreno, Estefanía, Moreno-Delgado, David, Navarro, Gemma, Quiroz, César, Rea, William, Sierakowiak, Adam   +17 more
core   +1 more source

β‐arrestin‐biased ACKR3 Promotes Gαi:β‐arrestin Complex Formation

The FASEB Journal, 2021
Atypical chemokine receptor 3 (ACKR3)—previously known as CXC‐chemokine receptor 7 (CXCR7)—is involved in a wide range of physiological processes including angiogenesis, neuronal development, and tumorigenesis. As a β‐arrestin biased G protein‐coupled receptor (GPCR), ACKR3 recruits β‐arrestin, but lacks G protein activity.
Taylor Kohlmann, Claudia Lee, Sudarshan Rajagopal   +2 more
openaire   +1 more source

Cannabinoid CB1 and CB2 Receptor-Mediated Arrestin Translocation: Species, Subtype, and Agonist-Dependence

Frontiers in Pharmacology, 2019
Arrestin translocation and signaling have come to the fore of the G protein-coupled receptor molecular pharmacology field. Some receptor–arrestin interactions are relatively well understood and considered responsible for specific therapeutic or adverse ...
Mikkel Søes Ibsen, Mikkel Søes Ibsen, David B. Finlay, Monica Patel, Monica Patel, Jonathan A. Javitch, Jonathan A. Javitch, Michelle Glass, Natasha Lillia Grimsey, Natasha Lillia Grimsey   +9 more
doaj   +1 more source

Novel Electrophilic and Photoaffinity Covalent Probes for Mapping the Cannabinoid 1 Receptor Allosteric Site(s) [PDF]

, 2015
ACKNOWLEDGMENTS The work was supported by National Institutes of Health grants DA027113 and EY024717 to G.A.T. and DA09158 to A.M. A portion of this work was submitted in 2011 by A. Kulkarni in partial fulfillment of M.S.
Cascio, Maria G., Denovan-Wright, Eileen M., Janero, David R., Korde, Anisha, Kulkarni, Abhijit R., Kulkarni, Pushkar M., Laprairie, Robert B., Makriyannis, Alexandros, Pertwee, Roger G., Thakur, Ganesh A., Tichkule, Ritesh B., Zhou, Han, Zvonok, Nikolai   +12 more
core   +3 more sources

Functional characterization of an arrestin gene on insecticide resistance of Culex pipiens pallens

Parasites & Vectors, 2012
Background Continuous and excessive application of insecticides has resulted in the rapid development of insecticide resistance in several mosquito species, including Culex pipiens pallens.
Sun Yan, Zou Ping, Yu Xin-You, Chen Chen, Yu Jing, Shi Lin-Na, Hong Shan-Chao, Zhou Dan, Chang Xue-Lian, Wang Wei-Jie, Shen Bo, Zhang Dong-Hui, Ma Lei, Zhu Chang-Liang   +13 more
doaj   +1 more source

PTEN controls glandular morphogenesis through a juxtamembrane β-Arrestin1/ARHGAP21 scaffolding complex [PDF]

, 2017
PTEN controls three-dimensional (3D) glandular morphogenesis by coupling juxtamembrane signalling to mitotic spindle machinery. While molecular mechanisms remain unclear, PTEN interacts through its C2 membrane-binding domain with the scaffold protein β ...
Anderson, Anthony, Barnes, Boehm, Boisvert, Bos, Campbell, Cantley, Capes-Davis, Caserta, Clevers, Corbalán-García, Crossman, Deevi, Deevi, Dubois, Dubois, Durgan, Décaillot, Eisenmann, Enslen, Eroglu, Furia, Ge, Glover, Hanahan, Hao, Hietakangas, Irazoqui, Jaffe, Jagan, Jagan, Jia, Johnston, Klompstra, Kovacs, Kumari, Lee, Lee, Leslie, Li, Lima-Fernandes, Lima-Fernandes, Liu Tj, Luttrell, Ma, Magudia, Maier, Martin-Belmonte, Meitinger, Meuillet, Misticone, Morin, Nagasaki, Naguib, Naguib, Narbonne, Noda, Ogg, Oh, Pertz, Pálmer, Raftopoulou, Raftopoulou, Rahdar, Rock, Rouault, Salmena, Sanchez, Sato, Shukla, Slorach, Smith, Song, Song, Söderberg, Tait, Torres, Ueda, Urs, Walker, Weng, Yun   +82 more
core   +3 more sources