Results 91 to 100 of about 27,706 (210)

Efficacy of Miltefosine and Artemether on infected Biomphalaria alexandrina snails with Schistosoma mansoni: immunological and histological studies

Helminthologia, 2020
Biomphalaria alexandrina snails have received much attention due to their great medical importance as vectors for transmitting Schistosoma mansoni infection to humans.
Abdel-Azeem H. H., Osman G. Y., El Garhy M. F., Al Benasy K. S.   +3 more
doaj   +1 more source

Artemisinin‐Based Combination Therapies in East Africa: A Systematic Review of Quality, Clinical Efficacy, and Regulatory Progress Towards Sustainable Malaria Control

Tropical Medicine &International Health, Volume 31, Issue 3, Page 254-273, March 2026.
ABSTRACT Background Malaria is a major public health issue in East Africa, leading to widespread illness and fatalities, especially among vulnerable populations such as children under 5 years of age and pregnant women. Artemisinin‐based combination therapies (ACTs) are the primary treatment modality; however, their efficacy is undermined by the ...
Yesuneh Tefera Mekasha, Addisu Afrassa Tegegne, Tapfumanei Mashe, Million Girma, Gemmechu Hasen, Sileshi Belew   +5 more
wiley   +1 more source

Adherence to a Six-Dose Regimen of Artemether-Lumefantrine for Treatment of Uncomplicated Plasmodium Falciparum Malaria in Uganda. [PDF]

, 2004
Measuring baseline levels of adherence and identifying risk factors for non-adherence are important steps before the introduction of new antimalarials. In Mbarara in southwestern Uganda, we assessed adherence to artemether-lumefantrine (Coartem) in its ...
Bajunirwe, F, Bajunirwe, Francis, Guthmann, J P, Piola, P, Musabe, Joy, Namiiro, P, Piola, Patrice, Biraro, S, Checchi, F, Namiiro, Proscovia, Checchi, Francesco, Guthmann, Jean-Paul, Biraro, Samuel, Kyomugisha, A, Musabe, J, Kiguli, James, Kiguli, J, Kyomugisha, Agnes, Fogg, C, Fogg, Carole   +19 more
core   +1 more source

Antimalarial Polyethylene Glycol–Lumefantrine Conjugates: Synthesis and Effect of Linker Chemistry on Drug Release

Advanced Therapeutics, Volume 9, Issue 2, February 2026.
Research into advanced therapeutics for malaria are rare. We investigate how linker chemistry governs the release kinetics of the antimalarial lumefantrine from polyethylene glycol conjugates. A clear correlation between diacid linker length and drug release rate is established, enabling rational design of conjugates with controlled release.
Thenesia R. Govender, William M. R. Matshe, Nokuthula Dube, Zamani E. D. Cele, Aurelia A. Williams, Lynne A. Pilcher, Mohammed O. Balogun   +6 more
wiley   +1 more source

Artemether-Lumefantrine Treatment Failure despite adequate lumefantrine day 7 Concentration in a Traveller with Plasmodium Falciparum Malaria after Returning from Tanzania. [PDF]

Artemether-lumefantrine is currently first-line therapy of Plasmodium falciparum malaria in many countries. This report describes a treatment failure despite adequate drug concentrations in a traveller returning from sub-Saharan Africa.
Färnert, Anna, Karlsson, Lillemor, Tolfvenstam, Thomas, Lindegårdh, Niklas, Ursing, Johan, Sparrelid, Elda, Rono, Josea   +6 more
core  

Artemether-Lumefantrine versus Dihydroartemisinin-Piperaquine for Treatment of Malaria: A Randomized Trial-1

, 2011
Copyright information:Taken from "Artemether-Lumefantrine versus Dihydroartemisinin-Piperaquine for Treatment of Malaria: A Randomized Trial"PLoS Clinical Trials 2007;2(5):-.Published online 18 May 2007PMCID:PMC1876597. © 2007 Kamya et al.
Moses R Kamya (18018), Myers Lugemwa (74818), John B Rwakimari (74819), Sarah G Staedke (18026), Fred Wabwire-Mangen (18024), Hasifa Bukirwa (18016), Ambrose O Talisuna (51375), Bryan Greenhouse (74820), François Nosten (17237), Adoke Yeka (18017), Grant Dorsey (18025), Philip J Rosenthal (18023)   +11 more
core   +1 more source

The HSP90/Akt pathway may mediate artemether‐induced apoptosis of Cal27 cells

FEBS Open Bio, 2019
Tongue squamous cell carcinoma is the most common malignant tumor in oral and maxillofacial regions. Recent research has found that artemether can inhibit growth and induce apoptosis of cancer cells, although the mechanism is not clear. The present study
Jianhua Wu, Lei Li, Yiting Wang, Xiaobin Ren, Ken Lin, Yongwen He   +5 more
doaj   +1 more source

Artemether and Praziquantel: Origin, Mode of Action, Impact, and Suggested Application for Effective Control of Human Schistosomiasis

Tropical Medicine and Infectious Disease, 2018
The stumbling block for the continued, single-drug use of praziquantel (PZQ) against schistosomiasis is less justified by the risk of drug resistance than by the fact that this drug is inactive against juvenal parasites, which will mature and start egg ...
Robert Bergquist, Hala Elmorshedy
doaj   +1 more source

Artemether-Lumefantrine versus Dihydroartemisinin-Piperaquine for Treatment of Malaria: A Randomized Trial-0

, 2011
Copyright information:Taken from "Artemether-Lumefantrine versus Dihydroartemisinin-Piperaquine for Treatment of Malaria: A Randomized Trial"PLoS Clinical Trials 2007;2(5):-.Published online 18 May 2007PMCID:PMC1876597. © 2007 Kamya et al.
Moses R Kamya (18018), Myers Lugemwa (74818), John B Rwakimari (74819), Sarah G Staedke (18026), Fred Wabwire-Mangen (18024), Hasifa Bukirwa (18016), Ambrose O Talisuna (51375), Bryan Greenhouse (74820), François Nosten (17237), Adoke Yeka (18017), Grant Dorsey (18025), Philip J Rosenthal (18023)   +11 more
core   +1 more source

Molecular monitoring of Plasmodium falciparum resistance to artemisinin in Tanzania. [PDF]

, 2006
Artemisinin-based combination therapies (ACTs) are recommended for use against uncomplicated malaria in areas of multi-drug resistant malaria, such as sub-Saharan Africa.
Mugittu, Kefas, Beck, Hans Peter, Mugittu Kefas, Hassan Mshinda, Hans Beck, Mshinda Hassan, Blaise Genton, Kefas Mugittu, Genton Blaise, Beck Hans, Mshinda, Hassan, Genton, Blaise   +11 more
core   +1 more source